Gene info: ID 6424

Gene: SFRP4

GENE ID: 6424

Synonyms: FRP-4|FRPHE|FRZB-2|PYL|sFRP-4

Description: secreted frizzled related protein 4

Gene type: protein-coding

Location: 7p14.1

dbXrefs: Ensembl:ENSG00000106483 MIM:606570 Vega:OTTHUMG00000023026 UniprotKB:Q6FHJ7

RefSeq: NG_052980.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.513e-1 (AD) 7.208e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IGF2	0.641
ECM2	0.623
MYL9	0.603
CASQ2	0.591
NTN1	0.582
GPC3	0.582
VGLL3	0.562
ABI3BP	0.562
WNK4	0.561
CCND1	0.559

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ALOX15B	-0.358
EMX1	-0.352
LIN28B	-0.351
CCNF	-0.35
ULBP2	-0.344
GPR55	-0.34
IPCEF1	-0.339
SLC22A14	-0.337
GRB7	-0.335
EIF4E1B	-0.335

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00606	Cyclothiazide	Small Molecule	2259-96-3	Approved	Target
DB00790	Perindopril	Small Molecule	82834-16-0	Approved	Target

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SFRP4 mRNA"	23829299
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of SFRP4 mRNA"	23829299
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of SFRP4 mRNA	21983209
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFRP4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFRP4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFRP4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFRP4 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of SFRP4 mRNA	26690555
D000092	Acetohexamide	Acetohexamide binds to SFRP4 protein	25019556
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SFRP4 gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of SFRP4 mRNA	21757418
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SFRP4 mRNA	16483693
D001151	Arsenic	Arsenic affects the expression of SFRP4 protein	24675094
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SFRP4 mRNA	15894712
C015001	arsenite	arsenite results in decreased expression of SFRP4 mRNA	15894712
C015001	arsenite	arsenite results in increased expression of SFRP4 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in increased expression of SFRP4 mRNA]	18929588
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SFRP4 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SFRP4 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SFRP4 mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of SFRP4 mRNA	23144751
D001645	Biguanides	Biguanides analog affects the expression of SFRP4 mRNA	17463086
C006780	bisphenol A	bisphenol A results in decreased expression of SFRP4 mRNA	25181051
D002064	Buserelin	[Buserelin co-treated with CGB3 protein] results in decreased expression of SFRP4 mRNA	19955106
C018475	butyraldehyde	butyraldehyde results in decreased expression of SFRP4 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of SFRP4 promoter	22457795
D003005	Clopamide	Clopamide binds to SFRP4 protein	25019556
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SFRP4 mRNA	19549813
C004639	cyclothiazide	cyclothiazide binds to SFRP4 protein	25019556
C014347	decitabine	[decitabine affects the methylation of SFRP4] which affects the expression of SFRP4 mRNA	17463086
C014347	decitabine	[decitabine co-treated with trichostatin A] results in increased expression of SFRP4 mRNA	17923031
C014347	decitabine	decitabine results in increased expression of SFRP4 mRNA	27915011
D013759	Dronabinol	Dronabinol results in increased expression of SFRP4 mRNA	16616335
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of SFRP4 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of SFRP4 mRNA	27392435
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SFRP4 mRNA	17394237
D002117	Calcitriol	Calcitriol results in decreased expression of SFRP4 mRNA	26485663
D004237	Diuron	Diuron results in decreased expression of SFRP4 mRNA	25152437
D004726	Endosulfan	Endosulfan results in increased expression of SFRP4 mRNA	26159488
D004726	Endosulfan	Tetrachlorodibenzodioxin inhibits the reaction [Endosulfan results in increased expression of SFRP4 mRNA]	26159488
D004397	Fonofos	Fonofos results in decreased methylation of SFRP4 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in decreased expression of SFRP4 mRNA	24304932
C039281	furan	furan results in increased expression of SFRP4 mRNA	27387713
D019833	Genistein	Genistein results in decreased expression of SFRP4 mRNA	15256057
C010974	glyphosate	glyphosate results in decreased expression of SFRP4 mRNA	28780397
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of SFRP4 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of SFRP4 mRNA	27392435
C002385	linsidomine	linsidomine results in increased oxidation of SFRP4 protein	28086193
D008942	Mitoxantrone	SFRP4 mRNA affects the susceptibility to Mitoxantrone	16044152
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SFRP4 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of SFRP4 mRNA	25583101
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SFRP4 mRNA	27935865
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in decreased expression of SFRP4 mRNA	24888373
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of SFRP4 mRNA	25729387
D010278	Parathion	Parathion results in decreased methylation of SFRP4 promoter	22847954
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of SFRP4 mRNA	23892564
D020913	Perindopril	Perindopril binds to SFRP4 protein	25019556
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFRP4 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SFRP4 mRNA	26272509
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SFRP4 mRNA	27935865
D011073	Polyamines	Polyamines analog affects the expression of SFRP4 mRNA	17463086
D011073	Polyamines	Polyamines analog results in increased expression of SFRP4 mRNA	19934284
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in decreased expression of SFRP4 mRNA	24888373
D011374	Progesterone	Progesterone results in increased expression of SFRP4 mRNA	22238285
D011374	Progesterone	Progesterone results in increased expression of SFRP4	17510236
D012834	Silver	Silver results in decreased expression of SFRP4 mRNA	27131904
D012999	Soman	Soman results in increased expression of SFRP4 mRNA	19281266
C012568	terbufos	terbufos results in decreased methylation of SFRP4 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Endosulfan results in increased expression of SFRP4 mRNA]	26159488
C009495	titanium dioxide	titanium dioxide results in decreased expression of SFRP4 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of SFRP4 mRNA	25729387
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in increased expression of SFRP4 mRNA	17923031
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of SFRP4 mRNA	19042947
D014520	Urethane	Urethane results in decreased expression of SFRP4 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFRP4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of SFRP4 mRNA	23179753\|2627250
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of SFRP4 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of SFRP4 mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	15607035
GO:0017147	Wnt-protein binding	-	IBA	21873635
GO:0017147	Wnt-protein binding	-	IDA	17462603
GO:0017147	Wnt-protein binding	-	IPI	17462603
GO:0017147	Wnt-protein binding	-	NAS	24431302
GO:0042813	Wnt-activated receptor activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002092	positive regulation of receptor internalization	-	IDA	16151791
GO:0007186	G-protein coupled receptor signaling pathway	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IMP	14760084 15705870
GO:0009725	response to hormone	-	NAS	10211996
GO:0010628	positive regulation of gene expression	-	IDA	18938133
GO:0030154	cell differentiation	-	IEA	-
GO:0030178	negative regulation of Wnt signaling pathway	-	NAS	24431302
GO:0030510	regulation of BMP signaling pathway	-	ISS	-
GO:0035567	non-canonical Wnt signaling pathway	-	IBA	21873635
GO:0043065	positive regulation of apoptotic process	-	IMP	15705870
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IDA	18945944
GO:0045606	positive regulation of epidermal cell differentiation	-	IDA	18938133
GO:0055062	phosphate ion homeostasis	-	IDA	12952927 16151791
GO:0060070	canonical Wnt signaling pathway	-	IBA	21873635
GO:0060349	bone morphogenesis	-	IMP	27355534
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IBA	21873635
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IDA	18945944
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IMP	14760084 15705870
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IGI	18166153
GO:1902174	positive regulation of keratinocyte apoptotic process	-	IDA	18938133
GO:2000051	negative regulation of non-canonical Wnt signaling pathway	-	ISS	-
GO:2000119	negative regulation of sodium-dependent phosphate transport	-	IDA	12952927 16151791

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	14760084
GO:0005634	nucleus	-	IDA	18938133
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	11793365 14760084 18938133
GO:0005886	plasma membrane	-	IBA	21873635
GO:0009986	cell surface	-	IDA	14760084
GO:0016021	integral component of membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa04310	Wnt signaling pathway

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16708382	Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. (2006 Oct 15)	Marsit CJ	Int J Cancer
26457595	Significant Association Between Polymorphisms of Wnt Antagonist Genes and Lung Cancer. (2015 Dec)	Yilmaz M	J Investig Med