Gene: ABCG5

64240
STSL
ATP binding cassette subfamily G member 5
protein-coding
2p21
Ensembl:ENSG00000138075 MIM:605459 Vega:OTTHUMG00000128758 UniprotKB:Q9H222
NG_008883.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.790e-1 (AD)  3.681e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C2CD50.673
ABCA50.67
ORC50.667
ZRANB30.656
CYP4X10.655
ZNF5400.65
RPGRIP1L0.649
SLC25A160.648
CCNB10.648
PPIP5K10.648

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C4orf19-0.398
TMEM176A-0.391
RAB13-0.38
YES1-0.38
TMEM176B-0.379
FGF11-0.373
TMEM102-0.37
ROM1-0.369
FXYD3-0.363
SLC2A4-0.361

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00973EzetimibeSmall Molecule163222-33-1ApprovedTransporter
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ABCG5 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ABCG5 mRNA"28903501
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA]28549656
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABCG5 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABCG5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABCG5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABCG5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABCG5 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ABCG5 mRNA"21346803
C0109873-DOXYLANDROSTANOL3-DOXYLANDROSTANOL results in increased activity of [ABCG5 protein binds to ABCG8 protein]17055487
C0005982004-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid"4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of ABCG5 mRNA"22918042
C0005982004-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid"NR1H4 gene mutant form inhibits the reaction [4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of ABCG5 mRNA]"22918042
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ABCG5 mRNA"25380136
C0030017-ketocholesterol[7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA23454145
C0030017-ketocholesterol[7-ketocholesterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA23454145
C0030017-ketocholesterol[7-ketocholesterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA23454145
C0030017-ketocholesterol7-ketocholesterol results in decreased expression of ABCG5 mRNA23454145
D000082AcetaminophenAcetaminophen results in decreased expression of ABCG5 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ABCG5 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABCG5 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ABCG5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ABCG5 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ABCG5 mRNA23630614
D000638AmiodaroneAmiodarone affects the expression of ABCG5 mRNA19483382
D000638AmiodaroneAmiodarone results in increased expression of ABCG5 mRNA27765674
D000639AmitriptylineAmitriptyline results in decreased expression of ABCG5 mRNA27765674
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABCG5 mRNA16483693
D000735AndrostenedioneAndrostenedione results in increased activity of [ABCG5 protein binds to ABCG8 protein]17055487
D001151ArsenicArsenic affects the methylation of ABCG5 gene25304211
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of ABCG5 mRNA25278499
D001379AzathioprineAzathioprine results in decreased expression of ABCG5 mRNA27765674
D001398AztreonamAztreonam results in increased expression of ABCG5 mRNA24657338
D001553BenzbromaroneBenzbromarone affects the expression of ABCG5 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABCG5 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCG5 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of ABCG5 mRNA20106945
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ABCG5 mRNA26496021
D001629BezafibrateBezafibrate results in increased expression of ABCG5 mRNA14685799
C006780bisphenol Abisphenol A results in increased expression of ABCG5 mRNA26364221
C006780bisphenol Abisphenol A affects the expression of ABCG5 mRNA27502578
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ABCG5 mRNA26496021
C086232bosentanbosentan results in increased expression of ABCG5 mRNA27765674
D019256Cadmium ChlorideCadmium Chloride affects the expression of ABCG5 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ABCG5 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ABCG5 mRNA27339419
D002330CarmustineABCG5 mRNA affects the susceptibility to Carmustine16365179
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of ABCG5 mRNA25055961|2717416
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of ABCG5 mRNA25582706
D020355CholatesCholates promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]15611112
D020355CholatesCholates results in increased expression of ABCG5 mRNA15611112
D020355CholatesCholates results in increased expression of ABCG5 protein15611112
D002784CholesterolABCG5 protein affects the export of Cholesterol15696852
D002784CholesterolCholesterol results in increased expression of ABCG5 mRNA15342687
D002784CholesterolABCG5 protein results in increased secretion of Cholesterol15611112
D002784CholesterolCholates promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]15611112
D002784Cholesterol[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCG5 mRNA18356535
D002784CholesterolCholesterol results in increased expression of ABCG5 mRNA15683829
D002784CholesterolDiosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]15611112
D002784CholesterolCholesterol results in decreased expression of ABCG5 mRNA15683829
D002784CholesterolCholesterol results in increased expression of ABCG5 mRNA15683829
D002784Cholesterol[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol12963437
D002784Cholesterol[Ethinyl Estradiol results in decreased expression of ABCG5 mRNA] which results in decreased secretion of Cholesterol12963437
D002784Cholesterol[ABCG5 protein binds to ABCG8 protein] which affects the transport of Cholesterol15683829
D019826Cholic AcidCholic Acid results in increased expression of ABCG5 mRNA25055961
D019826Cholic AcidCholic Acid results in increased expression of ABCG5 mRNA25582706
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ABCG5 mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCG5 mRNA27344345
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ABCG5 mRNA28472532
D002994ClofibrateClofibrate inhibits the reaction [PPARA gene mutant form results in increased expression of ABCG5 mRNA]29175453
D002994ClofibrateClofibrate results in decreased expression of ABCG5 mRNA28973556
D002994ClofibrateClofibrate results in increased expression of ABCG5 mRNA22496397
D002994ClofibrateClofibrate affects the expression of ABCG5 mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of ABCG5 mRNA12851107
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCG5 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of ABCG5 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ABCG5 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ABCG5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ABCG5 mRNA20106945|2556210
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein]17055487
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of ABCG5 mRNA25055961
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of ABCG5 mRNA21914718|2558270
D003840Deoxycholic AcidSLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in increased expression of ABCG5 mRNA]21914718
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ABCG5 mRNA28962523
C121718dicyclanildicyclanil results in increased expression of ABCG5 mRNA15664270
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ABCG5 mRNA26924002
D004041Dietary Fats[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCG5 mRNA18356535
D004041Dietary FatsDietary Fats affects the expression of ABCG5 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of ABCG5 mRNA18457598
D004041Dietary FatsDietary Fats results in decreased expression of ABCG5 protein22447684
D004041Dietary FatsDietary Fats results in increased expression of ABCG5 mRNA22447684|2260994
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in decreased expression of ABCG5 protein]22447684
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of ABCG5 mRNA]22447684
D019422Dietary SucroseDietary Sucrose results in decreased expression of ABCG5 mRNA26033743
D004051Diethylhexyl Phthalate[APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate] which results in decreased expression of ABCG5 protein25270622
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCG5 mRNA17602206
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG5 mRNA22129741
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ABCG5 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate affects the expression of ABCG5 mRNA26924002
D004144DiosgeninDiosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]15611112
D004144DiosgeninDiosgenin results in increased expression of ABCG5 mRNA12963437
D004144Diosgenin[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol12963437
D004144Diosgenin[Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA16105132
D004318DoxycyclineDoxycycline results in increased expression of ABCG5 mRNA27765674
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of ABCG5 mRNA24412560
D004997Ethinyl EstradiolESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCG5 mRNA]16606610
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ABCG5 mRNA16606610
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ABCG5 mRNA26865667
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA16105132
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ABCG5 mRNA12963437|1610513
D004997Ethinyl Estradiol[Ethinyl Estradiol results in decreased expression of ABCG5 mRNA] which results in decreased secretion of Cholesterol12963437
D005001EthionineEthionine affects the expression of ABCG5 mRNA19483382
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ABCG5 gene16495775
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated results in decreased expression of ABCG5 mRNA"18356535
D011345FenofibrateFenofibrate results in increased expression of ABCG5 mRNA27765674
C082360fipronilfipronil results in increased expression of ABCG5 mRNA23962444
C082360fipronilfipronil results in increased expression of ABCG5 mRNA23962444
D015378Imipenem[Vancomycin co-treated with Imipenem] affects the expression of ABCG5 mRNA24657338
C039281furanfuran results in increased expression of ABCG5 mRNA25539665|2619464
D019833GenisteinGenistein results in decreased expression of ABCG5 mRNA26865667
D005897GlafenineGlafenine results in decreased expression of ABCG5 mRNA24136188
D005905GlyburideGlyburide results in increased expression of ABCG5 mRNA27765674
C473027GW 3965GW 3965 results in increased expression of ABCG5 mRNA15633131
C412815GW 4064GW 4064 results in increased expression of ABCG5 mRNA22918042
C412815GW 4064NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]22918042
C010176halofuginonehalofuginone results in decreased expression of ABCG5 mRNA17180598
C016517indole-3-carbinolindole-3-carbinol affects the expression of ABCG5 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG5 mRNA22129741
C045463leflunomideleflunomide results in decreased expression of ABCG5 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ABCG5 mRNA15312237
D008095Lithocholic AcidLithocholic Acid results in increased expression of ABCG5 mRNA25055961
D008095Lithocholic Acid[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of ABCG5 mRNA20359477
D008095Lithocholic AcidLithocholic Acid results in increased expression of ABCG5 mRNA25582706
D008148LovastatinLovastatin affects the expression of ABCG5 mRNA27208389
D008687MetforminMetformin results in decreased expression of ABCG5 mRNA27765674
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCG5 mRNA27344345
D008917MirexMirex results in increased expression of ABCG5 mRNA23153324
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ABCG5 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of ABCG5 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ABCG5 mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ABCG5 mRNA27344345
D0150581-Naphthylisothiocyanate18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA]28549656
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA28549656
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA25380136|2776567
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ABCG5 mRNA27765674
C051752nefazodonenefazodone results in increased expression of ABCG5 mRNA24136188
D009840Oligomycins[7-ketocholesterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA23454145
D009840Oligomycins[Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA23454145
C026209oltipraz[oltipraz co-treated with NFE2L2 protein mutant form] affects the expression of ABCG5 mRNA22496397
D009853OmeprazoleOmeprazole affects the expression of ABCG5 mRNA19483382
D010098OxycodoneOxycodone results in increased expression of ABCG5 mRNA23439660
D000073878Palm OilPalm Oil affects the expression of ABCG5 mRNA19680557
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABCG5 mRNA"25510870
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of ABCG5 mRNA21705711
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of ABCG5 mRNA29112762
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ABCG5 mRNA27153767
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ABCG5 mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ABCG5 mRNA21723365
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ABCG5 mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ABCG5 mRNA21723365
D010480PerhexilinePerhexiline results in decreased expression of ABCG5 mRNA27765674
D010634PhenobarbitalPhenobarbital affects the expression of ABCG5 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ABCG5 mRNA19270015
D010840Phytosterols[ABCG5 protein binds to ABCG8 protein] which affects the transport of Phytosterols15683829
C006253pirinixic acidpirinixic acid affects the expression of ABCG5 mRNA19483382
C407042plant stanol esterplant stanol ester results in decreased expression of ABCG5 mRNA15342687
D011192Potassium DichromatePotassium Dichromate results in increased expression of ABCG5 mRNA23608068
D017035PravastatinPravastatin results in increased expression of ABCG5 mRNA15242490
D011285Pregnenolone Carbonitrile[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of ABCG5 mRNA20359477
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ABCG5 mRNA20359477
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ABCG5 mRNA15683829
D011374ProgesteroneProgesterone results in decreased activity of [ABCG5 protein binds to ABCG8 protein]17055487
C045950propiconazolepropiconazole results in decreased expression of ABCG5 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of ABCG5 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of ABCG5 mRNA19483382
D011794QuercetinQuercetin results in decreased expression of ABCG5 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in decreased expression of ABCG5 protein]22447684
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of ABCG5 mRNA]22447684
D015125OxyquinolineOxyquinoline results in decreased expression of ABCG5 mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of ABCG5 mRNA21515302
D012402Rotenone[7-ketocholesterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA23454145
D012402Rotenone[Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA23454145
D012402RotenoneRotenone results in increased expression of ABCG5 mRNA27979718
D019821SimvastatinSimvastatin results in increased expression of ABCG5 mRNA21241519
C016104sodium bichromatesodium bichromate results in decreased expression of ABCG5 mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of ABCG5 mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of ABCG5 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of ABCG5 mRNA27862939
D013148SpironolactoneSpironolactone results in decreased expression of ABCG5 mRNA15683829
D013261SterolsABCG5 protein affects the export of Sterols15737409
D013261SterolsABCG5 protein affects the export of Sterols15930516
D013265Stigmasterol[Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA23454145
D013265Stigmasterol[Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA23454145
D013265Stigmasterol[Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA23454145
D013265StigmasterolStigmasterol results in decreased expression of ABCG5 mRNA23454145
D013311StreptozocinStreptozocin results in increased expression of ABCG5 mRNA23319174
C446685systhanesysthane results in increased expression of ABCG5 mRNA19409404
C013698tallowtallow affects the expression of ABCG5 mRNA19680557
D013629TamoxifenTamoxifen results in increased expression of ABCG5 mRNA25123088
C047246temozolomideABCG5 mRNA affects the susceptibility to temozolomide16365179
C501413tesaglitazartesaglitazar results in increased expression of ABCG5 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCG5 mRNA20106945|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCG5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in increased expression of ABCG5 mRNA22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ABCG5 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in decreased expression of ABCG5 mRNA]21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCG5 mRNA28238261
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCG5 mRNA19770486|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCG5 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ABCG5 mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of ABCG5 mRNA24489787
D013752TetracyclineTetracycline results in decreased expression of ABCG5 mRNA27765674
D013853ThioacetamideThioacetamide affects the expression of ABCG5 mRNA19483382
D013853ThioacetamideThioacetamide results in increased expression of ABCG5 mRNA23411599
C050504tianeptinetianeptine results in increased expression of ABCG5 mRNA27765674
C423915TO-901317TO-901317 results in increased expression of ABCG5 mRNA23146569
D014050TolueneToluene affects the expression of ABCG5 mRNA18653662
C032910triadimefontriadimefon results in increased expression of ABCG5 mRNA19409404
C009564trilinoleintrilinolein results in decreased expression of ABCG5 mRNA18356535
C101314trilinolenintrilinolenin results in decreased expression of ABCG5 mRNA18356535
D014304TrioleinTriolein results in decreased expression of ABCG5 mRNA18356535
C057693troglitazonetroglitazone results in increased expression of ABCG5 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of ABCG5 mRNA21515302
D014502Uranyl NitrateUranyl Nitrate results in increased expression of ABCG5 mRNA20362056
D014520UrethaneUrethane results in decreased expression of ABCG5 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of ABCG5 mRNA25582706
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of ABCG5 mRNA15452192
C406224valdecoxibvaldecoxib results in increased expression of ABCG5 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of ABCG5 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ABCG5 mRNA27765674
D014638VanadatesVanadates results in decreased activity of [ABCG5 protein binds to ABCG8 protein]17055487
D014640Vancomycin[Vancomycin co-treated with Imipenem] affects the expression of ABCG5 mRNA24657338
C540004WAY-362450NR1H4 gene mutant form inhibits the reaction [WAY-362450 results in increased expression of ABCG5 mRNA]22918042
C540004WAY-362450WAY-362450 results in increased expression of ABCG5 mRNA22918042
D015032ZincZinc deficiency results in decreased expression of ABCG5 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16870176  17474147  
GO:0005524ATP bindingcontributes_toIDA16893193  
GO:0015238drug transmembrane transporter activity-IBA21873635  
GO:0016887ATPase activitycontributes_toIDA16893193  
GO:0017127cholesterol transporter activityCONTRIBUTES_TOIBA21873635  
GO:0017127cholesterol transporter activitycontributes_toIGI14504269  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IDA27144356  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IPI16870176  
GO ID GO Term Qualifier Evidence PubMed
GO:0007584response to nutrient-IEA-  
GO:0007588excretion-IGI14504269  
GO:0010212response to ionizing radiation-IEA-  
GO:0010949negative regulation of intestinal phytosterol absorption-IMP11099417  
GO:0030299intestinal cholesterol absorption-IC12208868  
GO:0033344cholesterol efflux-IBA21873635  
GO:0033344cholesterol efflux-IGI14504269  
GO:0033344cholesterol efflux-IMP27144356  
GO:0042632cholesterol homeostasis-IMP11099417  27144356  
GO:0045796negative regulation of intestinal cholesterol absorption-IMP11099417  
GO:0055085transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0016324apical plasma membrane-IBA21873635  
GO:0016324apical plasma membrane-IMP14504269  
GO:0016324apical plasma membrane-ISS-  
GO:0043190ATP-binding cassette (ABC) transporter complex-IDA16893193  27144356  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA14504269  
KEGG ID KEGG Term
hsa02010ABC transporters
hsa04975Fat digestion and absorption
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1369062ABC transporters in lipid homeostasisTAS
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5679090Defective ABCG8 causes gallbladder disease 4 and sitosterolemiaTAS
R-HSA-5679096Defective ABCG5 causes sitosterolemiaTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19005228The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. (2009 Mar)Junyent MJ Lipid Res
24691589ABCG5/8 variants are associated with susceptibility to coronary heart disease. (2014 Jun)Wu GMol Med Rep
20172523Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia. (2010 Jun)Garcia-Rios AAtherosclerosis