Gene: ABCG8

64241
GBD4|STSL
ATP binding cassette subfamily G member 8
protein-coding
2p21
Ensembl:ENSG00000143921 MIM:605460 Vega:OTTHUMG00000128756 UniprotKB:Q9H221
NG_008884.1
PubMed
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.056e-1 (AD)  4.609e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBC1D300.832
LMLN0.822
ZNF1690.815
GLB1L20.812
KSR20.807
UNC790.806
SLITRK50.806
VSTM50.803
DRP20.802
ATP2B30.801

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.56
S100A16-0.497
YES1-0.488
EMP3-0.487
HEY2-0.484
RAI14-0.483
WWTR1-0.481
BCL7C-0.48
TMEM102-0.479
CMTM3-0.478

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00973EzetimibeSmall Molecule163222-33-1ApprovedTransporter
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ABCG8 mRNA"21354444|2890350
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl affects the expression of ABCG8 mRNA"24050789
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABCG8 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCG8 mRNA]"23756648
C0109873-DOXYLANDROSTANOL3-DOXYLANDROSTANOL results in increased activity of [ABCG5 protein binds to ABCG8 protein]17055487
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ABCG8 mRNA"25380136
C0030017-ketocholesterol[7-ketocholesterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA23454145
C0030017-ketocholesterol[7-ketocholesterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA23454145
D000082AcetaminophenAcetaminophen results in decreased expression of ABCG8 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ABCG8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ABCG8 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABCG8 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ABCG8 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ABCG8 mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ABCG8 mRNA21298039
D000639AmitriptylineAmitriptyline results in decreased expression of ABCG8 mRNA27765674
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABCG8 mRNA16483693
D000735AndrostenedioneAndrostenedione results in increased activity of [ABCG5 protein binds to ABCG8 protein]17055487
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of ABCG8 mRNA25278499
D001398AztreonamAztreonam results in increased expression of ABCG8 mRNA24657338
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABCG8 mRNA20106945
D004958EstradiolEstradiol results in decreased expression of ABCG8 mRNA20106945
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ABCG8 mRNA26496021
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCG8 mRNA]"23756648
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ABCG8 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ABCG8 mRNA25181051
C584056BMS-764459BMS-764459 results in increased expression of ABCG8 mRNA23831372
C086232bosentanbosentan results in increased expression of ABCG8 mRNA27765674
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ABCG8 promoter22457795
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of ABCG8 mRNA27174168
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of ABCG8 mRNA25582706
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA27344345
D004390ChlorpyrifosChlorpyrifos results in increased expression of ABCG8 mRNA20691718
D020355CholatesCholates promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]15611112
D020355CholatesCholates results in increased expression of ABCG8 mRNA15611112
D020355CholatesCholates results in increased expression of ABCG8 protein15611112
D002784CholesterolABCG8 protein affects the export of Cholesterol15696852
D002784CholesterolCholesterol results in increased expression of ABCG8 mRNA15342687
D002784CholesterolABCG8 protein results in increased secretion of Cholesterol15611112
D002784CholesterolCholates promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]15611112
D002784Cholesterol[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCG8 mRNA18356535
D002784CholesterolCholesterol results in increased expression of ABCG8 mRNA15683829
D002784CholesterolDiosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]15611112
D002784CholesterolCholesterol results in decreased expression of ABCG8 mRNA15683829
D002784CholesterolCholesterol results in increased expression of ABCG8 mRNA15683829
D002784Cholesterol[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol12963437
D002784Cholesterol[Ethinyl Estradiol results in decreased expression of ABCG8 mRNA] which results in decreased secretion of Cholesterol12963437
D002784Cholesterol[ABCG5 protein binds to ABCG8 protein] which affects the transport of Cholesterol15683829
D019826Cholic AcidCholic Acid results in increased expression of ABCG8 mRNA25582706
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ABCG8 mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of ABCG8 mRNA27344345
D002994ClofibrateClofibrate inhibits the reaction [PPARA gene mutant form results in increased expression of ABCG8 mRNA]29175453
D002994ClofibrateClofibrate results in decreased expression of ABCG8 mRNA28973556
C018021cobaltous chloridecobaltous chloride results in decreased expression of ABCG8 mRNA24386269
D003314Corn OilCorn Oil affects the expression of ABCG8 mRNA16360708
D016572CyclosporineCyclosporine results in decreased expression of ABCG8 mRNA20106945|2556210
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein]17055487
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of ABCG8 mRNA21914718|2558270
D003840Deoxycholic AcidSLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in increased expression of ABCG8 mRNA]21914718
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ABCG8 mRNA26924002
D004041Dietary Fats[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCG8 mRNA18356535
D004041Dietary FatsDietary Fats affects the expression of ABCG8 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of ABCG8 mRNA18457598|2501614
D004041Dietary FatsDietary Fats results in increased expression of ABCG8 mRNA23756648
D004041Dietary Fats"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCG8 mRNA]"23756648
D004051Diethylhexyl Phthalate[APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate] which results in decreased expression of ABCG8 protein25270622
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCG8 mRNA]"23756648
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG8 mRNA22129741
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ABCG8 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate affects the expression of ABCG8 mRNA26924002
D004144DiosgeninDiosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]15611112
D004144DiosgeninDiosgenin results in increased expression of ABCG8 mRNA12963437
D004144Diosgenin[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol12963437
D004144Diosgenin[Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNA16105132
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ABCG8 mRNA26159488
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of ABCG8 mRNA24412560
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of ABCG8 mRNA27344345
D004997Ethinyl EstradiolESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCG8 mRNA]16606610
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ABCG8 mRNA16606610
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNA16105132
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ABCG8 mRNA12963437|1610513
D004997Ethinyl Estradiol[Ethinyl Estradiol results in decreased expression of ABCG8 mRNA] which results in decreased secretion of Cholesterol12963437
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated results in decreased expression of ABCG8 mRNA"18356535
D011345FenofibrateFenofibrate results in increased expression of ABCG8 mRNA27765674
C082360fipronilfipronil results in increased expression of ABCG8 mRNA23962444
C082360fipronilfipronil results in increased expression of ABCG8 mRNA23962444
D004397FonofosABCG8 gene SNP affects the susceptibility to Fonofos22919386
D015378Imipenem[Vancomycin co-treated with Imipenem] affects the expression of ABCG8 mRNA24657338
C473027GW 3965GW 3965 results in increased expression of ABCG8 mRNA15633131
C010176halofuginonehalofuginone results in decreased expression of ABCG8 mRNA17180598
C016517indole-3-carbinolindole-3-carbinol affects the expression of ABCG8 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG8 mRNA22129741
C045463leflunomideleflunomide results in decreased expression of ABCG8 mRNA28988120
D008095Lithocholic AcidLithocholic Acid results in decreased expression of ABCG8 mRNA20359477
D008095Lithocholic AcidLithocholic Acid results in increased expression of ABCG8 mRNA25582706
D008148LovastatinLovastatin affects the expression of ABCG8 mRNA27208389
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ABCG8 mRNA26011545
D008795MetronidazoleMetronidazole results in increased expression of ABCG8 mRNA24657338
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ABCG8 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABCG8 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ABCG8 mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ABCG8 mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ABCG8 mRNA25380136|2776567
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ABCG8 mRNA27765674
C051752nefazodonenefazodone results in increased expression of ABCG8 mRNA24136188
D009840Oligomycins[7-ketocholesterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA23454145
D009840Oligomycins[Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA23454145
D000073878Palm OilPalm Oil affects the expression of ABCG8 mRNA19680557
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of ABCG8 mRNA21705711
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of ABCG8 mRNA29112762
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ABCG8 mRNA21705711
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ABCG8 mRNA17681415
D010634PhenobarbitalPhenobarbital affects the expression of ABCG8 mRNA23091169
D010840Phytosterols[ABCG5 protein binds to ABCG8 protein] which affects the transport of Phytosterols15683829
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ABCG8 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ABCG8 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of ABCG8 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of ABCG8 mRNA23557933
C407042plant stanol esterplant stanol ester results in decreased expression of ABCG8 mRNA15342687
D017035PravastatinPravastatin results in increased expression of ABCG8 mRNA15242490
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ABCG8 mRNA15683829
D011374ProgesteroneProgesterone results in decreased activity of [ABCG5 protein binds to ABCG8 protein]17055487
C045950propiconazolepropiconazole results in decreased expression of ABCG8 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of ABCG8 mRNA21632981
D012293RifampinRifampin results in increased expression of ABCG8 mRNA27199754
D012402Rotenone[7-ketocholesterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA23454145
D012402Rotenone[Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA23454145
D019821SimvastatinSimvastatin results in decreased expression of ABCG8 mRNA27765674
C016104sodium bichromatesodium bichromate results in decreased expression of ABCG8 mRNA24612858
C102006sodium citratesodium citrate results in decreased expression of ABCG8 mRNA27765674
D053260SootSoot results in increased expression of ABCG8 mRNA22461453
D013148SpironolactoneSpironolactone results in decreased expression of ABCG8 mRNA15683829
D013261SterolsABCG8 protein affects the export of Sterols15737409
D013261SterolsABCG8 protein affects the export of Sterols15930516
D013265Stigmasterol[Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA23454145
D013265Stigmasterol[Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA23454145
D013265StigmasterolStigmasterol results in decreased expression of ABCG8 mRNA23454145
D013311StreptozocinStreptozocin results in increased expression of ABCG8 mRNA23319174
C013698tallowtallow affects the expression of ABCG8 mRNA19680557
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ABCG8 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCG8 mRNA20106945|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCG8 mRNA21632981
D013749Tetrachlorodibenzodioxin[NFE2L2 gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ABCG8 mRNA21846477
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCG8 mRNA]"23756648
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCG8 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCG8 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCG8 mRNA21215274
D013752TetracyclineTetracycline results in decreased expression of ABCG8 mRNA24489787
D013853ThioacetamideThioacetamide results in increased expression of ABCG8 mRNA23411599
C050504tianeptinetianeptine results in increased expression of ABCG8 mRNA27765674
D014050TolueneToluene affects the expression of ABCG8 mRNA18653662
C009564trilinoleintrilinolein results in decreased expression of ABCG8 mRNA18356535
C101314trilinolenintrilinolenin results in decreased expression of ABCG8 mRNA18356535
D014304TrioleinTriolein results in decreased expression of ABCG8 mRNA18356535
C057693troglitazonetroglitazone results in decreased expression of ABCG8 mRNA28973697
D014502Uranyl NitrateUranyl Nitrate results in increased expression of ABCG8 mRNA20362056
D014520UrethaneUrethane results in decreased expression of ABCG8 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of ABCG8 mRNA25582706
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of ABCG8 mRNA15452192
D014635Valproic AcidValproic Acid results in decreased expression of ABCG8 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of ABCG8 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ABCG8 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of ABCG8 mRNA27765674
D014638VanadatesVanadates results in decreased activity of [ABCG5 protein binds to ABCG8 protein]17055487
D014640Vancomycin[Vancomycin co-treated with Imipenem] affects the expression of ABCG8 mRNA24657338
D015215ZidovudineZidovudine results in decreased expression of ABCG8 mRNA27765674

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16870176  
GO:0005524ATP bindingcontributes_toIDA16893193  
GO:0015238drug transmembrane transporter activity-IBA21873635  
GO:0016887ATPase activitycontributes_toIDA16893193  
GO:0017127cholesterol transporter activityCONTRIBUTES_TOIBA21873635  
GO:0017127cholesterol transporter activitycontributes_toIGI14504269  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IDA27144356  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IPI16870176  
GO ID GO Term Qualifier Evidence PubMed
GO:0007588excretion-IGI14504269  
GO:0010949negative regulation of intestinal phytosterol absorption-IMP11099417  
GO:0030299intestinal cholesterol absorption-IC12208868  
GO:0033344cholesterol efflux-IBA21873635  
GO:0033344cholesterol efflux-IGI14504269  
GO:0033344cholesterol efflux-IMP27144356  
GO:0042632cholesterol homeostasis-IMP11099417  27144356  
GO:0045796negative regulation of intestinal cholesterol absorption-IMP11099417  
GO:0055085transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0016324apical plasma membrane-IBA21873635  
GO:0016324apical plasma membrane-IMP14504269  
GO:0016324apical plasma membrane-ISS-  
GO:0043190ATP-binding cassette (ABC) transporter complex-IDA16893193  27144356  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA14504269  
KEGG ID KEGG Term
hsa02010ABC transporters
hsa04975Fat digestion and absorption
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1369062ABC transporters in lipid homeostasisTAS
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5679090Defective ABCG8 causes gallbladder disease 4 and sitosterolemiaTAS
R-HSA-5679096Defective ABCG5 causes sitosterolemiaTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20592455Effect of genetic variant (rs11887534) in ABCG8 gene in coronary artery disease and response to atorvastatin therapy. (2010)Srivastava ADis Markers
24346170Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). (2014 Jan 29)Meyers KJInvest Ophthalmol Vis Sci
24691589ABCG5/8 variants are associated with susceptibility to coronary heart disease. (2014 Jun)Wu GMol Med Rep
20172523Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia. (2010 Jun)Garcia-Rios AAtherosclerosis
19005228The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. (2009 Mar)Junyent MJ Lipid Res