Gene: SFRP5

6425
SARP3
secreted frizzled related protein 5
protein-coding
10q24.2
Ensembl:ENSG00000120057 MIM:604158 Vega:OTTHUMG00000018866 UniprotKB:Q5T4F7
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.701e-3 (AD)  8.295e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02363630chr10:99532138SFRP54.600e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CFC10.787
SCGN0.757
C22orf420.73
HCRT0.719
OTP0.717
FEZF10.715
NTS0.712
FOXB10.71
HMX20.709
TRH0.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PEAR1-0.413
FZD10-0.399
PDGFRB-0.392
GJC1-0.384
P2RY14-0.381
TBX2-0.38
CSAG1-0.373
TBX15-0.372
ANPEP-0.369
MAGEA12-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of SFRP5 mRNA"26377693
D000082AcetaminophenAcetaminophen affects the expression of SFRP5 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SFRP5 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SFRP5 mRNA21298039
D001104ArbutinArbutin results in decreased expression of SFRP5 mRNA17103032
D001151ArsenicArsenic affects the methylation of SFRP5 gene25304211
D001280AtrazineAtrazine results in decreased expression of SFRP5 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of SFRP5 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SFRP5 mRNA22316170
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SFRP5 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SFRP5 mRNA27195522
D001645BiguanidesBiguanides analog affects the expression of SFRP5 mRNA17463086
C006780bisphenol Abisphenol A results in increased expression of SFRP5 mRNA26562050
C006780bisphenol Abisphenol A results in decreased expression of SFRP5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SFRP5 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SFRP5 mRNA23741332
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SFRP5 mRNA27188386
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of SFRP5 mRNA21356183
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of SFRP5 mRNA21356183
D003300CopperCopper results in increased expression of SFRP5 mRNA21356183
C029892cupric chloridecupric chloride results in increased expression of SFRP5 mRNA19174923
D003474CurcuminCurcumin results in decreased expression of SFRP5 mRNA16101141
C014347decitabinedecitabine affects the methylation of SFRP5 promoter17882284
C014347decitabine[decitabine affects the methylation of SFRP5 promoter] which affects the expression of SFRP5 mRNA18283316|1828331
C014347decitabine[decitabine affects the methylation of SFRP5] which affects the expression of SFRP5 mRNA17463086
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of SFRP5 mRNA17923031
C014347decitabinedecitabine results in decreased methylation of SFRP5 promoter19387464
C014347decitabinedecitabine results in increased expression of SFRP5 mRNA19387464
C014347decitabinedecitabine results in increased expression of SFRP5 mRNA27915011
C016366dibenzothiophenedibenzothiophene results in increased expression of SFRP5 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SFRP5 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of SFRP5 mRNA18042831
D004147DioxinsDioxins affects the expression of SFRP5 mRNA20463971
C004312glycidolglycidol results in decreased expression of SFRP5 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of SFRP5 mRNA28973697
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SFRP5 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SFRP5 mRNA29191790
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of SFRP5 mRNA"25487280
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of SFRP5 mRNA19074003
D000073878Palm OilPalm Oil results in increased expression of SFRP5 mRNA18042831
D010936Plant ExtractsPlant Extracts results in decreased expression of SFRP5 mRNA23557933
D011073PolyaminesPolyamines analog affects the expression of SFRP5 mRNA17463086
D011441PropylthiouracilPropylthiouracil results in decreased expression of SFRP5 mRNA24780913
C009277sodium arsenatesodium arsenate results in decreased expression of SFRP5 mRNA23922661
D013629TamoxifenTamoxifen results in increased expression of SFRP5 mRNA25123088
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of SFRP5 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of SFRP5 5' UTR28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of SFRP5 exon28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of SFRP5 promoter28011154
D013893ThiramThiram results in increased expression of SFRP5 mRNA20530235
C479163tofacitinibtofacitinib results in increased expression of SFRP5 mRNA25487280
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of SFRP5 mRNA17923031
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SFRP5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017147Wnt-protein binding-IBA21873635  
GO:0017147Wnt-protein binding-NAS24431302  
GO:0042813Wnt-activated receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-TAS9391078  
GO:0007163establishment or maintenance of cell polarity-TAS10072424  
GO:0007165signal transduction-TAS10072424  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007601visual perception-TAS10072424  
GO:0008285negative regulation of cell proliferation-IMP19957335  
GO:0009653anatomical structure morphogenesis-TAS10072424  
GO:0030154cell differentiation-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-NAS24431302  
GO:0030510regulation of BMP signaling pathway-IEA-  
GO:0035567non-canonical Wnt signaling pathway-IBA21873635  
GO:0043433negative regulation of DNA-binding transcription factor activity-IMP19957335  
GO:0051898negative regulation of protein kinase B signaling-IMP19957335  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP19957335  
GO:2000057negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis-IMP18981481  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-TAS10072424  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16708382Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. (2006 Oct 15)Marsit CJInt J Cancer