Gene: SRSF1

6426
ASF|SF2|SF2p33|SFRS1|SRp30a
serine and arginine rich splicing factor 1
protein-coding
17q22
Ensembl:ENSG00000136450 MIM:600812 Vega:OTTHUMG00000178781 UniprotKB:Q07955
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.608e-1 (AD)  8.898e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPA2B10.954
RBM390.949
HNRNPA30.949
TARDBP0.945
HNRNPU0.931
IST10.927
HNRNPH10.92
ST130.917
DDX50.915
CSDE10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.865
OR4F5-0.847
KRTAP19-1-0.093
OR4F16-0.093
MBD3L3-0.087
HOXD4-0.083
HES5-0.079
SEC14L3-0.078
HMHB1-0.078
ZNF705D-0.076

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of SRSF1 mRNA"22101062
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRSF1 mRNA"19167446
D000082AcetaminophenAcetaminophen results in decreased expression of SRSF1 mRNA11793227|2142099
D000082AcetaminophenAcetaminophen affects the expression of SRSF1 mRNA17562736
C016601afimoxifeneafimoxifene results in decreased expression of SRSF1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SRSF1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SRSF1 mRNA19770486
C103505AM 251AM 251 results in decreased expression of SRSF1 mRNA16500647
D000965AntimonyAntimony results in decreased expression of SRSF1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of SRSF1 mRNA17547211
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SRSF1 mRNA24449571
D004958EstradiolEstradiol results in increased expression of SRSF1 mRNA16514628|1916744
C004541biochanin Abiochanin A results in decreased expression of SRSF1 mRNA12111696
C006780bisphenol Abisphenol A results in decreased expression of SRSF1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of SRSF1 mRNA20977926
C013418bromfenacoumbromfenacoum results in decreased expression of SRSF1 protein28903499
D002084Butylated HydroxytolueneButylated Hydroxytoluene affects the localization of SRSF1 protein15390079
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein15390079
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein15390079
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of SRSF1 protein15390079
D002110CaffeineCaffeine results in decreased expression of SRSF1 mRNA11793227
D002220CarbamazepineCarbamazepine affects the expression of SRSF1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SRSF1 mRNA27339419
D002518CeramidesCeramides results in increased expression of and affects the localization of SRSF1 protein25195822
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SRSF1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRSF1 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SRSF1 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of SRSF1 mRNA17553155|1932097
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SRSF1 mRNA20971185
D003300CopperSRSF1 protein binds to Copper15359738
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRSF1 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of SRSF1 mRNA19167446
D003474CurcuminCurcumin results in increased expression of SRSF1 mRNA17999991
D016572CyclosporineCyclosporine results in decreased expression of SRSF1 mRNA25562108
D013759DronabinolDronabinol results in decreased expression of SRSF1 mRNA12237329
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of SRSF1 protein23811945
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of SRSF1 protein23352502
C042577diallyl trisulfidediallyl trisulfide results in increased expression of SRSF1 protein16344271
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRSF1 mRNA17361019
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SRSF1 mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SRSF1 mRNA17547211
D004147DioxinsDioxins affects the expression of SRSF1 mRNA20463971
D004317DoxorubicinSRSF1 protein results in increased susceptibility to Doxorubicin25195822
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SRSF1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SRSF1 mRNA16954407
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SRSF1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SRSF1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRSF1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SRSF1 mRNA23649840
C070081fulvestrantfulvestrant results in decreased expression of SRSF1 mRNA16514628
D005839GentamicinsGentamicins results in increased expression of SRSF1 mRNA22061828
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in increased expression of SRSF1 protein17569113
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SRSF1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRSF1 mRNA25613284
C045463leflunomideleflunomide results in decreased expression of SRSF1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SRSF1 mRNA"18930950
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRSF1 gene20938992
D008727MethotrexateMethotrexate affects the expression of SRSF1 mRNA18502557
D008748Methylcholanthrene[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein15390079
D008748Methylcholanthrene[Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein15390079
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SRSF1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SRSF1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SRSF1 mRNA"20188158
D016685MitomycinSRSF1 protein affects the susceptibility to Mitomycin16217747
C523799MRK 003SRSF1 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SRSF1 mRNA"25554681|2562005
C101954N-caproylsphingosineSRSF1 protein promotes the reaction [N-caproylsphingosine affects the splicing of and results in increased expression of TP53 mRNA]25195822
C101954N-caproylsphingosineSRSF1 protein promotes the reaction [N-caproylsphingosine results in increased expression of BAX protein]25195822
C101954N-caproylsphingosineSRSF1 protein promotes the reaction [N-caproylsphingosine results in increased expression of CDKN1A protein]25195822
C101954N-caproylsphingosineSRSF1 protein promotes the reaction [N-caproylsphingosine results in increased expression of TP53 protein modified form]25195822
C101954N-caproylsphingosineSRSF1 protein results in increased susceptibility to N-caproylsphingosine25195822
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SRSF1 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of SRSF1 protein19445961
D010100OxygenOxygen deficiency affects the methylation of SRSF1 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of SRSF1 mRNA24205000
D010269ParaquatParaquat affects the localization of SRSF1 protein23613995
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SRSF1 protein26879310
D019800PhenolPhenol results in decreased expression of SRSF1 mRNA17547211
D010795Phthalic AcidsPhthalic Acids results in increased expression of SRSF1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of SRSF1 mRNA18445702
D010894PiroxicamPiroxicam results in increased expression of SRSF1 mRNA21858171
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of SRSF1 mRNA22579512
D011441PropylthiouracilPropylthiouracil results in increased expression of SRSF1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SRSF1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of SRSF1 mRNA16514628
C059514resveratrolresveratrol results in decreased expression of SRSF1 protein25505154
D012643SeleniumSelenium results in increased expression of SRSF1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SRSF1 mRNA19073995
D012834SilverSilver results in decreased expression of SRSF1 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of SRSF1 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of SRSF1 protein27548804
D018038Sodium SeleniteSodium Selenite results in increased expression of SRSF1 mRNA18175754
D013629TamoxifenTamoxifen affects the expression of SRSF1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRSF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SRSF1 mRNA15591033|1977048
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRSF1 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of SRSF1 mRNA11793227
D014212TretinoinTretinoin results in decreased expression of SRSF1 mRNA10022522
D014212TretinoinTretinoin results in decreased expression of SRSF1 mRNA alternative form10022522
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SRSF1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SRSF1 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SRSF1 mRNA"18930950
D014635Valproic AcidValproic Acid results in decreased expression of SRSF1 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SRSF1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-IDA19561594  
GO:0003723RNA binding-IPI20797886  
GO:0003729mRNA binding-IDA21984414  
GO:0005515protein binding-IPI9237760  9299613  9885563  10196197  15184380  15243141  
15652350  15798186  17353931  18596238  21296756  21822258  
21988832  22365833  23602568  23604122  
GO:0043422protein kinase B binding-IEA-  
GO:0044547DNA topoisomerase binding-IPI9611241  
GO:0050733RS domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000380alternative mRNA splicing, via spliceosome-IDA8940107  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0000395mRNA 5'-splice site recognition-IDA8940107  9885563  
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0001701in utero embryonic development-IEA-  
GO:0006376mRNA splice site selection-TAS1830244  
GO:0006397mRNA processing-TAS1830244  
GO:0006405RNA export from nucleus-TAS-  
GO:0006406mRNA export from nucleus-TAS-  
GO:0031124mRNA 3'-end processing-TAS-  
GO:0033120positive regulation of RNA splicing-IEA-  
GO:0045292mRNA cis splicing, via spliceosome-IBA21873635  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0060048cardiac muscle contraction-IEA-  
GO:0097421liver regeneration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA21984414  
GO:0005654nucleoplasm-IDA9885563  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016607nuclear speck-IBA21873635  
GO:0016607nuclear speck-IDA20797886  
GO:0035145exon-exon junction complexcolocalizes_withIDA16314458  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-109688Cleavage of Growing Transcript in the Termination Region TAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72165mRNA Splicing - Minor PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72187mRNA 3'-end processingTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73856RNA Polymerase II Transcription TerminationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28800142Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity. (2017 Oct)Sariyer RAlcohol Clin Exp Res
26498691SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. (2015 Nov 10)Tian JOncotarget