Gene: SRSF2

6427
PR264|SC-35|SC35|SFRS2|SFRS2A|SRp30b
serine and arginine rich splicing factor 2
protein-coding
17q25.1
Ensembl:ENSG00000161547 MIM:600813 Vega:OTTHUMG00000177547 UniprotKB:Q01130
NG_032905.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.383e-1 (AD)  3.978e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPD0.925
DDX39B0.918
EIF2B10.911
TAF110.91
APEX10.903
IK0.902
OXA1L0.902
GLT8D10.902
PHB20.902
EWSR10.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.806
OR4F29-0.774
MTRNR2L9-0.211
MTRNR2L6-0.186
MTRNR2L10-0.168
HMHB1-0.152
MOGAT2-0.149
OR4F16-0.143
FOXJ1-0.125
C8orf74-0.124

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of SRSF2 mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SRSF2 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of SRSF2 mRNA"19095052
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SRSF2 mRNA"17547211
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SRSF2 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SRSF2 mRNA"15215175
D000082AcetaminophenAcetaminophen affects the expression of SRSF2 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SRSF2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SRSF2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SRSF2 mRNA19770486
D024502alpha-Tocopherolalpha-Tocopherol deficiency results in decreased expression of SRSF2 protein15247049
C053442annonacinannonacin results in increased expression of SRSF2 protein25402454
C053442annonacinSRSF2 promotes the reaction [annonacin results in increased expression of MAPT protein alternative form]25402454
C053442annonacinSRSF2 promotes the reaction [annonacin results in increased splicing of MAPT mRNA]25402454
C039726artesunateSRSF2 mRNA results in decreased susceptibility to artesunate20144594
D001554BenzeneBenzene results in increased expression of SRSF2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRSF2 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SRSF2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRSF2 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KAT5 protein results in increased acetylation of and results in increased degradation of SRSF2 protein]21157427
D004958EstradiolEstradiol affects the expression of SRSF2 mRNA15598610
D004958EstradiolEstradiol results in increased expression of SRSF2 mRNA14664709
C095105bexarotenebexarotene results in decreased expression of SRSF2 mRNA17178900
C006780bisphenol Abisphenol A results in decreased expression of SRSF2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of SRSF2 mRNA26512966
C006780bisphenol Abisphenol A affects the expression of SRSF2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SRSF2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SRSF2 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of SRSF2 protein19552622
D002065BuspironeBuspirone results in decreased expression of SRSF2 mRNA24136188
D020148Butyric AcidButyric Acid promotes the reaction [KAT5 protein results in increased acetylation of SRSF2 protein]21555914
D020148Butyric AcidButyric Acid promotes the reaction [SRSF2 protein binds to HDAC6 protein]21555914
D020148Butyric AcidButyric Acid promotes the reaction [SRSF2 protein binds to KAT5 protein]21555914
D020148Butyric AcidButyric Acid results in decreased phosphorylation of SRSF2 protein21555914
D020148Butyric AcidButyric Acid results in increased expression of SRSF2 protein21555914
D020148Butyric Acid[Butyric Acid results in increased expression of SRSF2 protein] which results in increased expression of CDKN1A mRNA21555914
D020148Butyric Acid[Butyric Acid results in increased expression of SRSF2 protein] which results in increased expression of CDKN1A protein21555914
D020148Butyric AcidHDAC6 protein promotes the reaction [Butyric Acid results in increased expression of SRSF2 protein]21555914
D020148Butyric AcidKAT5 protein promotes the reaction [Butyric Acid results in increased expression of SRSF2 protein]21555914
D002104CadmiumCadmium results in increased expression of SRSF2 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRSF2 mRNA17547211
D002220CarbamazepineCarbamazepine affects the expression of SRSF2 mRNA25979313
D002273CarcinogensCarcinogens results in increased expression of SRSF2 mRNA16316942
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SRSF2 mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SRSF2 mRNA18804290
C100187chloropicrinchloropicrin affects the expression of SRSF2 mRNA26352163
D002857ChromiumChromium results in increased expression of SRSF2 mRNA17547211
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SRSF2 mRNA28472532
D002995Clofibric AcidClofibric Acid affects the expression of SRSF2 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SRSF2 mRNA19320972
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of SRSF2 protein20931265
D019327Copper SulfateCopper Sulfate results in increased expression of SRSF2 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of SRSF2 mRNA19167446
D003474CurcuminCurcumin results in increased expression of SRSF2 mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of SRSF2 mRNA25562108
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of SRSF2 protein23811945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRSF2 mRNA17361019
D002945Cisplatin[Cisplatin affects the localization of SRPK2 protein] which results in increased phosphorylation of SRSF2 protein21157427
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of SRSF2 mRNA]21858171
D002945CisplatinCisplatin results in decreased acetylation of SRSF2 protein21157427
D002945CisplatinCisplatin results in increased expression of SRSF2 protein21157427
D002945Cisplatin[Cisplatin results in increased expression of SRSF2 protein] which affects the splicing of CASP8 mRNA21157427
D002945Cisplatin[[Cisplatin results in increased expression of SRSF2 protein] which affects the splicing of CASP8 mRNA] which results in increased activity of CASP8 protein21157427
D002945CisplatinCisplatin results in increased phosphorylation of SRSF2 protein21157427
D002945CisplatinHDAC6 protein promotes the reaction [Cisplatin results in increased expression of SRSF2 protein]21157427
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SRSF2 mRNA27638505
D004147DioxinsDioxins affects the expression of SRSF2 mRNA20463971
D004237DiuronDiuron results in decreased expression of SRSF2 mRNA21551480
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SRSF2 mRNA23649840
D005485FlutamideFlutamide results in increased expression of SRSF2 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of SRSF2 mRNA23649840
D005897GlafenineGlafenine results in increased expression of SRSF2 mRNA24136188
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of SRSF2 mRNA25270620
C492448ICG 001ICG 001 results in decreased expression of SRSF2 mRNA26191083
D007545IsoproterenolIsoproterenol results in decreased expression of SRSF2 mRNA20003209
C011890kojic acidkojic acid results in increased expression of SRSF2 mRNA16595896
C008261lead acetatelead acetate results in decreased expression of SRSF2 mRNA21829687
C045463leflunomideleflunomide results in decreased expression of SRSF2 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of SRSF2 mRNA19751817
D001556LindaneLindane results in increased expression of SRSF2 mRNA17785943
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SRSF2 mRNA"18930950
D008628MercuryMercury results in increased expression of SRSF2 mRNA17547211
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SRSF2 mRNA23649840
D0156551-Methyl-4-phenylpyridiniumSRSF2 promotes the reaction [1-Methyl-4-phenylpyridinium results in increased splicing of MAPT mRNA]25402454
D009151Mustard GasMustard Gas results in decreased expression of SRSF2 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SRSF2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SRSF2 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of SRSF2 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of SRSF2 mRNA17547211
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SRSF2 mRNA25729387
D010269ParaquatParaquat affects the localization of SRSF2 protein23613995
D010634PhenobarbitalPhenobarbital affects the expression of SRSF2 mRNA23091169
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of SRSF2 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of SRSF2 mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in increased expression of SRSF2 mRNA17547211
D011441PropylthiouracilPropylthiouracil results in increased expression of SRSF2 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SRSF2 mRNA21427059
D012834SilverSilver results in increased expression of SRSF2 mRNA26014281
C017947sodium arsenitesodium arsenite results in increased expression of SRSF2 mRNA28595984
D012969Sodium FluorideSodium Fluoride results in decreased expression of SRSF2 protein28918527
D012999SomanSoman results in increased expression of SRSF2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRSF2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRSF2 mRNA22298810
D019284ThapsigarginThapsigargin results in decreased expression of SRSF2 mRNA22378314
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of SRSF2 protein20931265
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SRSF2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SRSF2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SRSF2 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SRSF2 mRNA"18930950
C080163trovafloxacintrovafloxacin results in decreased expression of SRSF2 mRNA24136188
D014415TunicamycinTunicamycin results in decreased expression of SRSF2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of SRSF2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SRSF2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SRSF2 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of SRSF2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SRSF2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-NAS15652350  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0005080protein kinase C binding-IEA-  
GO:0005515protein binding-IPI9237760  9447963  15652350  21157427  21296756  21504830  
GO:0036002pre-mRNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-IEA-  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IEA-  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006397mRNA processing-TAS8530103  
GO:0006405RNA export from nucleus-TAS-  
GO:0006406mRNA export from nucleus-TAS-  
GO:0008380RNA splicing-TAS8530103  
GO:0031124mRNA 3'-end processing-TAS-  
GO:0033197response to vitamin E-IEA-  
GO:0045292mRNA cis splicing, via spliceosome-IBA21873635  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15652350  15988025  17494991  19734146  21653549  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0016605PML bodyNOTIDA15652350  
GO:0016607nuclear speck-IBA21873635  
GO:0016607nuclear speck-IDA12799190  15798186  21984414  23562910  
GO:0016607nuclear speck-TAS28377597  
GO:0035061interchromatin granule-IEA-  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-109688Cleavage of Growing Transcript in the Termination Region TAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72165mRNA Splicing - Minor PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72187mRNA 3'-end processingTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73856RNA Polymerase II Transcription TerminationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26498691SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. (2015 Nov 10)Tian JOncotarget