Gene: ZSCAN31

64288
ZNF20-Lp|ZNF310P|ZNF323
zinc finger and SCAN domain containing 31
protein-coding
6p22.1|6p22.3-p22.1
Ensembl:ENSG00000235109 MIM:610794 Vega:OTTHUMG00000014518 UniprotKB:Q96LW9
NC_000006.12
PubMed
ND
1   
3.092e-1 (AD)  7.540e-1 (ND)   (Frontal_Cortex)
1.348e-1 (AD)  8.862e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C2orf420.681
IGF1R0.673
PKNOX10.671
ARNTL0.667
TSHZ10.663
SPATA20.655
ZNF4730.652
EYA30.651
CNOT40.648
TADA2B0.648

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH2D1A-0.35
OR4F5-0.337
CHP2-0.332
SDR42E1-0.322
KLRB1-0.316
KLRF1-0.311
C5orf64-0.309
CD48-0.298
OR4F29-0.296
SLC51B-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZSCAN31 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of ZSCAN31 mRNA22521957
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ZSCAN31 mRNA26272509
C018021cobaltous chloridecobaltous chloride results in increased expression of ZSCAN31 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of ZSCAN31 mRNA19549813
D003561CytarabineCytarabine results in increased expression of ZSCAN31 mRNA19194470
C051890irinotecanirinotecan analog results in decreased expression of ZSCAN31 mRNA18927307
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZSCAN31 mRNA25307878
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZSCAN31 mRNA28001369
D009532NickelNickel results in decreased expression of ZSCAN31 mRNA24768652
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ZSCAN31 mRNA26272509
D011794QuercetinQuercetin results in decreased expression of ZSCAN31 mRNA21632981
D012834SilverSilver results in increased expression of ZSCAN31 mRNA26014281
C017947sodium arsenitesodium arsenite results in increased expression of and affects the splicing of ZSCAN31 mRNA25879800
C012589trichostatin Atrichostatin A affects the expression of ZSCAN31 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZSCAN31 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ZSCAN31 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN31 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ZSCAN31 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZSCAN31 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28722770Asbestos-associated genome-wide DNA methylation changes in lung cancer. (2017 Nov 15)Kettunen EInt J Cancer