Gene: CXCR5

643
BLR1|CD185|MDR15
C-X-C motif chemokine receptor 5
protein-coding
11q23.3
Ensembl:ENSG00000160683 MIM:601613 Vega:OTTHUMG00000166345 UniprotKB:P32302
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.887e-1 (AD)  2.161e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs665648chr11:118894574 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12678834chr11:118753662CXCR53.400e-9Smoking27651444
cg01257799chr11:118753476CXCR51.790e-12Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR6C40.476
OR10G80.433
OR2T70.433
SPIB0.405
OR9G10.401
SPP20.4
IL31RA0.397
ISX0.382
LRRC3C0.382
CCL200.368

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFY-0.254
RPS4Y1-0.253
DDX3Y-0.249
NLGN4Y-0.249
EIF1AY-0.247
KDM5D-0.247
SFTPC-0.243
USP9Y-0.239
PLCXD1-0.239
TMSB4Y-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CXCR5 mRNA"19162173
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CXCR5 mRNA16483693
D001151ArsenicArsenic affects the expression of CXCR5 protein24675094
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of CXCR5 mRNA19962721
D001151ArsenicArsenic results in decreased expression of CXCR5 mRNA19962721
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in increased expression of CXCR5 mRNA16443354
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CXCR5 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CXCR5 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CXCR5 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CXCR5 mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene results in increased expression of CXCR5 mRNA]20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCR5 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCR5 protein20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CXCR5 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXCR5 mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of CXCR5 protein17578864
C006780bisphenol Abisphenol A results in decreased expression of CXCR5 mRNA26595511
C006780bisphenol Abisphenol A results in decreased expression of CXCR5 mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of CXCR5 mRNA19818335
C018475butyraldehydebutyraldehyde results in decreased expression of CXCR5 mRNA26079696
D002118CalciumCXCR5 protein affects the abundance of Calcium12055238
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCR5 mRNA]18038451
D007631ChlordeconeChlordecone results in increased expression of CXCR5 protein17578864
D002737ChloropreneChloroprene results in decreased expression of CXCR5 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CXCR5 mRNA27858113
C000488cladosporincladosporin results in increased expression of CXCR5 mRNA19818335
D003300CopperCopper deficiency results in increased expression of CXCR5 mRNA26033743
D004041Dietary FatsDietary Fats results in increased expression of CXCR5 mRNA25016146
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CXCR5 mRNA"22485181
D015025ZearalenoneZearalenone results in increased expression of CXCR5 mRNA27757495
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of CXCR5 mRNA19962721
D005459FluoridesFluorides results in decreased expression of CXCR5 mRNA19962721
C056933fumonisin B1fumonisin B1 results in decreased expression of CXCR5 mRNA27757495
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CXCR5 mRNA25613284
D007854LeadLead results in decreased expression of CXCR5 mRNA19921347
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CXCR5 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of CXCR5 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CXCR5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CXCR5 mRNA"25554681
C015380neoechinulinneoechinulin results in increased expression of CXCR5 mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of CXCR5 mRNA19818335
C046012pentanalpentanal results in decreased expression of CXCR5 mRNA26079696
C539933pevonedistatpevonedistat affects the expression of CXCR5 mRNA24634471
D010705PhosgenePhosgene affects the expression of CXCR5 mRNA16300373
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of CXCR5 mRNA12818353
D053260SootSoot affects the expression of CXCR5 mRNA26551751
D013241SterigmatocystinSterigmatocystin results in increased expression of CXCR5 mRNA19818335
C016766sulforafansulforafan results in increased expression of CXCR5 mRNA26833863
C061133tamibarotenetamibarotene results in increased expression of CXCR5 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCR5 mRNA20064835
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CXCR5 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CXCR5 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of CXCR5 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of CXCR5 mRNA23557971
C402696TMC 120ATMC 120A results in increased expression of CXCR5 mRNA19818335
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in increased expression of CXCR5 mRNA16443354
D014212TretinoinTretinoin results in increased expression of CXCR5 mRNA15498508
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CXCR5 mRNA19042947
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CXCR5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS1425907  
GO:0005515protein binding-IPI15251452  23773523  25241761  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016494C-X-C chemokine receptor activity-IEA-  
GO:0019956chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IBA21873635  
GO:0006955immune response-IBA21873635  
GO:0006955immune response-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0030595leukocyte chemotaxis-IEA-  
GO:0032467positive regulation of cytokinesis-IMP22888021  
GO:0042113B cell activation-IEA-  
GO:0048535lymph node development-IEA-  
GO:0060326cell chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1425907  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27244229Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia. (2016)Fernandez-Egea EPLoS One