Gene: SRSF7

6432
9G8|AAG3|SFRS7
serine and arginine rich splicing factor 7
protein-coding
2p22.1
Ensembl:ENSG00000115875 MIM:600572 Vega:OTTHUMG00000102076 UniprotKB:Q16629
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.602e-1 (AD)  5.947e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFG0.933
UBE2D30.92
CCT6A0.913
DERL10.912
EIF2B10.911
ARCN10.91
SSB0.909
ZNF2070.907
H2AFY0.906
RSRC20.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.708
OR4F29-0.679
C8orf74-0.215
MTRNR2L10-0.211
MTRNR2L6-0.199
HMHB1-0.195
MTRNR2L9-0.194
GLI1-0.19
KLRB1-0.188
KRTAP19-1-0.184

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SRSF7 mRNA"21354444
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SRSF7 mRNA"20453058
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SRSF7 mRNA"17547211
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRSF7 mRNA"27188386
C578491((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) inhibits the reaction [DYRK2 protein results in increased phosphorylation of SRSF7 protein]"21615147
C578491((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) inhibits the reaction [CLK1 protein results in increased phosphorylation of SRSF7 protein]"21615147
C578491((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) inhibits the reaction [CLK2 protein results in increased phosphorylation of SRSF7 protein]"21615147
C578491((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) inhibits the reaction [CLK4 protein results in increased phosphorylation of SRSF7 protein]"21615147
C578491((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) inhibits the reaction [DYRK3 protein results in increased phosphorylation of SRSF7 protein]"21615147
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRSF7 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SRSF7 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of SRSF7 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SRSF7 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SRSF7 mRNA]17585979
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of SRSF7 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SRSF7 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SRSF7 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of SRSF7 protein25419056
C015001arsenitearsenite results in increased methylation of SRSF7 promoter23974009
D001280AtrazineAtrazine results in increased expression of SRSF7 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of SRSF7 mRNA22378314
D001374AzacitidineAzacitidine results in decreased expression of SRSF7 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRSF7 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRSF7 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SRSF7 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SRSF7 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of SRSF7 mRNA20823114
C044887beta-methylcholinebeta-methylcholine affects the expression of SRSF7 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of SRSF7 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SRSF7 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of SRSF7 mRNA25181051
D002104CadmiumCadmium results in decreased expression of SRSF7 mRNA16439709
D019256Cadmium ChlorideCadmium Chloride affects the expression of SRSF7 mRNA20883709
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SRSF7 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SRSF7 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SRSF7 mRNA23650126
D002857ChromiumChromium results in increased expression of SRSF7 mRNA17547211
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SRSF7 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SRSF7 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of SRSF7 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SRSF7 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of SRSF7 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SRSF7 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of SRSF7 mRNA21621594
D013759DronabinolDronabinol results in decreased expression of SRSF7 mRNA18454173
D003907DexamethasoneDexamethasone results in decreased expression of SRSF7 mRNA21621594
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRSF7 mRNA17361019|2126653
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of SRSF7 mRNA20823114
C000944dicrotophosdicrotophos results in decreased expression of SRSF7 mRNA28302478
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of SRSF7 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of SRSF7 mRNA21233418
C069837fullerene C60fullerene C60 results in decreased expression of SRSF7 mRNA19167457
D006046GoldGold results in decreased expression of SRSF7 mRNA25523186
D017313FenretinideFenretinide results in increased expression of SRSF7 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SRSF7 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of SRSF7 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRSF7 mRNA25613284
C410337K 7174K 7174 results in decreased expression of SRSF7 mRNA24086573
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SRSF7 mRNA21641980
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of SRSF7 mRNA20823114
D008628MercuryMercury results in increased expression of SRSF7 mRNA17547211
D008713MethimazoleMethimazole results in increased expression of SRSF7 mRNA22504374
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SRSF7 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SRSF7 mRNA23179753|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SRSF7 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of SRSF7 mRNA12634122
C059539midostaurinmidostaurin results in increased expression of SRSF7 mRNA20980353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SRSF7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SRSF7 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of SRSF7 mRNA19167457
C570897NSC668394NSC668394 results in increased expression of SRSF7 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SRSF7 mRNA20971185
C507134ON 01910ON 01910 results in increased expression of SRSF7 mRNA22351695
D010081OxazoloneOxazolone results in increased expression of SRSF7 mRNA11379042
D010100OxygenOxygen deficiency results in decreased expression of SRSF7 mRNA24236059
D010269ParaquatParaquat results in decreased expression of SRSF7 mRNA26824344
C008776pelargonic acidpelargonic acid results in increased expression of SRSF7 mRNA11379042
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of SRSF7 protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SRSF7 protein19954255
D010416PentachlorophenolPentachlorophenol results in increased expression of SRSF7 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of SRSF7 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of SRSF7 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRSF7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SRSF7 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SRSF7 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of SRSF7 mRNA16985257|1830175
D010894PiroxicamPiroxicam results in decreased expression of SRSF7 mRNA21858171
D010936Plant ExtractsPlant Extracts results in decreased expression of SRSF7 mRNA24677778
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of SRSF7 mRNA22579512
D011192Potassium DichromatePotassium Dichromate results in increased expression of SRSF7 mRNA17547211
D011239PrednisolonePrednisolone results in decreased expression of SRSF7 mRNA21621594
C045950propiconazolepropiconazole results in increased expression of SRSF7 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of SRSF7 mRNA22504374|2478091
D011794QuercetinQuercetin results in decreased expression of SRSF7 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of SRSF7 mRNA16497877
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of SRSF7 mRNA19244175
D012643SeleniumSelenium results in decreased expression of SRSF7 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of SRSF7 mRNA20883709
D012969Sodium FluorideSodium Fluoride results in decreased expression of SRSF7 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of SRSF7 mRNA18175754
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SRSF7 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRSF7 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRSF7 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of SRSF7 mRNA22378314
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of SRSF7 mRNA"11379042
C012589trichostatin Atrichostatin A affects the expression of SRSF7 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of SRSF7 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SRSF7 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of SRSF7 mRNA22378314
D014520UrethaneUrethane results in decreased expression of SRSF7 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SRSF7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SRSF7 mRNA22083351|2317975
D014635Valproic AcidValproic Acid results in decreased methylation of SRSF7 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of SRSF7 mRNA20546886
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SRSF7 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SRSF7 mRNA23034163
D014750VincristineVincristine results in decreased expression of SRSF7 mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of SRSF7 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of SRSF7 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of SRSF7 mRNA22083351
D019287Zinc SulfateZinc Sulfate affects the expression of SRSF7 protein25162517

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0005515protein binding-IPI10749975  14559993  15169763  15184380  17036044  18624398  
23602568  25416956  
GO:0008270zinc ion binding-IEA-  
GO:0019904protein domain specific binding-IPI10749975  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006397mRNA processing-TAS8013463  
GO:0006405RNA export from nucleus-TAS-  
GO:0006406mRNA export from nucleus-TAS-  
GO:0008380RNA splicing-IDA8013463  
GO:0031124mRNA 3'-end processing-TAS-  
GO:0045292mRNA cis splicing, via spliceosome-IBA21873635  
GO:0048025negative regulation of mRNA splicing, via spliceosome-IDA15009664  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS8013463  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016607nuclear speck-IBA21873635  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-109688Cleavage of Growing Transcript in the Termination Region TAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72165mRNA Splicing - Minor PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72187mRNA 3'-end processingTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73856RNA Polymerase II Transcription TerminationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26162562Polymorphisms in alternative splicing associated genes are associated with lung cancer risk in a Chinese population. (2015 Sep)Shen WLung Cancer