Gene: NSD1

64324
ARA267|KMT3B|SOTOS|SOTOS1|STO
nuclear receptor binding SET domain protein 1
protein-coding
5q35.3
Ensembl:ENSG00000165671 MIM:606681 Vega:OTTHUMG00000130846 UniprotKB:Q96L73
NG_009821.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.083e-1 (AD)  8.606e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18121224chr5:176559563NSD14.490e-9Maternal smoking in pregnancy27040690
cg24711224chr5:176561865NSD11.700e-9Smoking27651444
cg19731612chr5:176559334NSD13.800e-8Alcohol consumption der day27843151
cg24711224chr5:176561865NSD15.440e-8Alcohol consumption der day27843151
cg19731612chr5:176559334NSD18.340e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UGGT10.94
ANKRD170.935
NCOA60.935
TRRAP0.931
ARID1B0.931
CREBBP0.93
PRR14L0.929
KDM2A0.928
MDN10.919
KMT2A0.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.556
OR4F29-0.526
KLRC2-0.303
KLRC3-0.287
NANOGNB-0.28
ODAM-0.279
RPE65-0.272
TRDN-0.269
CD8B-0.265
IRX5-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NSD1 mRNA"19114083
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NSD1 protein modified form]"28751236
D000082AcetaminophenAcetaminophen affects the expression of NSD1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NSD1 mRNA19770486
D000450Aldosterone[Aldosterone binds to NR3C2 protein] which binds to NSD1 protein15761029
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NSD1 mRNA"17331233
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of NSD1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NSD1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NSD1 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NSD1 mRNA27858113
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NSD1 protein modified form]28751236
C006780bisphenol Abisphenol A affects the expression of NSD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of NSD1 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of NSD1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NSD1 promoter22457795
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NSD1 mRNA27858113
D002994ClofibrateClofibrate results in decreased expression of NSD1 mRNA17585979
D003033Coal TarCoal Tar results in decreased expression of NSD1 mRNA27858113
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NSD1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NSD1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of NSD1 mRNA27594783
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NSD1 mRNA29097150
D005557FormaldehydeFormaldehyde results in increased expression of NSD1 mRNA23649840
C039281furanfuran results in increased methylation of NSD1 gene22079235
C010974glyphosateglyphosate results in increased expression of NSD1 mRNA26302742
D017313FenretinideFenretinide results in decreased expression of NSD1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NSD1 mRNA25613284
D007854LeadLead affects the expression of NSD1 mRNA28903495
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NSD1 mRNA26378955
D008727MethotrexateMethotrexate affects the expression of NSD1 mRNA18502557
D009151Mustard GasMustard Gas results in decreased expression of NSD1 mRNA26392148
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NSD1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NSD1 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NSD1 mRNA23978341
D010795Phthalic AcidsPhthalic Acids results in increased expression of NSD1 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NSD1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of NSD1 mRNA20813756
C009277sodium arsenatesodium arsenate results in increased expression of NSD1 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of NSD1 mRNA16014739
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NSD1 mRNA26378955
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NSD1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of NSD1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NSD1 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of NSD1 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of NSD1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of NSD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NSD1 mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in increased expression of NSD1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of NSD1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of NSD1 mRNA19136453
C029297vinylidene chloridevinylidene chloride results in decreased expression of NSD1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20837538  
GO:0003682chromatin binding-ISS-  
GO:0003712transcription coregulator activity-IDA11509567  
GO:0003714transcription corepressor activity-ISS-  
GO:0005515protein binding-IPI20080798  
GO:0008270zinc ion binding-IDA21196496  
GO:0018024histone-lysine N-methyltransferase activity-TAS-  
GO:0030331estrogen receptor binding-ISS-  
GO:0042799histone methyltransferase activity (H4-K20 specific)-ISS-  
GO:0042974retinoic acid receptor binding-ISS-  
GO:0046965retinoid X receptor binding-ISS-  
GO:0046966thyroid hormone receptor binding-ISS-  
GO:0046975histone methyltransferase activity (H3-K36 specific)-IDA21196496  
GO:0046975histone methyltransferase activity (H3-K36 specific)-ISS-  
GO:0050681androgen receptor binding-IDA11509567  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0000414regulation of histone H3-K36 methylation-IMP20837538  
GO:0006351transcription, DNA-templated-IEA-  
GO:0010452histone H3-K36 methylation-IEA-  
GO:0016571histone methylation-ISS-  
GO:0033135regulation of peptidyl-serine phosphorylation-IMP20837538  
GO:0034770histone H4-K20 methylation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA11509567  
GO:1903025regulation of RNA polymerase II regulatory region sequence-specific DNA binding-IMP20837538  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
KEGG ID KEGG Term
hsa00310Lysine degradation
Reactome ID Reactome Term Evidence
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26464434Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites. (2016 Feb 18)Lee STNucleic Acids Res
25631445Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)-Nature
27213592Relationship of smoking status to genomic profile, chemotherapy response and clinical outcome in patients with advanced urothelial carcinoma. (2016 Aug 9)Joshi MOncotarget