Gene: MMP25

64386
MMP-25|MMP20|MMP20A|MMPL1|MT-MMP 6|MT-MMP6|MT6-MMP|MT6MMP|MTMMP6
matrix metallopeptidase 25
protein-coding
16p13.3
Ensembl:ENSG00000008516 MIM:608482 Vega:OTTHUMG00000177475 UniprotKB:Q9NPA2
NC_000016.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.277e-1 (AD)  6.720e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1004792chr16:3044260 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VNN20.821
CXCR10.809
CD1770.793
CST70.778
S100A120.773
LILRA50.769
PROK20.768
IL18RAP0.764
KCNJ150.763
CXCR20.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA4-0.44
MAGIX-0.423
ASPDH-0.421
SLC32A1-0.421
SP9-0.421
LRRC73-0.418
EXTL1-0.417
STK32C-0.417
BCL11A-0.416
FAM57B-0.415

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00786MarimastatSmall Molecule154039-60-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MMP25 mRNA"22698814
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP25 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP25 mRNA"27188386
D000111AcetylcysteineAcetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP25 mRNA]21635667
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MMP25 mRNA24449571
C022921benzo(k)fluorantheneAcetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP25 mRNA]21635667
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of MMP25 mRNA21635667
C022921benzo(k)fluorantheneSB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP25 mRNA]21635667
C006780bisphenol Abisphenol A results in decreased expression of MMP25 mRNA25181051
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of MMP25 mRNA25167922
D003300CopperCopper deficiency results in increased expression of MMP25 mRNA26033743
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MMP25 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MMP25 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of MMP25 mRNA26033743
C118739entinostatentinostat results in increased expression of MMP25 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP25 mRNA"27188386
C069837fullerene C60fullerene C60 results in decreased expression of MMP25 mRNA19167457
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MMP25 mRNA17183730
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MMP25 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MMP25 mRNA27392435
C008261lead acetatelead acetate results in increased expression of MMP25 mRNA20542052
C028007nickel monoxidenickel monoxide results in decreased expression of MMP25 mRNA19167457
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of MMP25 mRNA25167922
D011441PropylthiouracilPropylthiouracil results in decreased expression of MMP25 mRNA24780913
C093642SB 203580SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP25 mRNA]21635667
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MMP25 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MMP25 mRNA26377647
D014212TretinoinTretinoin results in decreased expression of MMP25 mRNA23724009
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MMP25 mRNA17183730
C034028vanadyl sulfatevanadyl sulfate results in increased expression of MMP25 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MMP25 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-NAS10706098  
GO:0006954inflammatory response-NAS10628838  
GO:0043312neutrophil degranulation-TAS-  
GO:0060022hard palate development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-NAS11034316  
GO:0016021integral component of membrane-IEA-  
GO:0031012extracellular matrix-NAS10628838  
GO:0031225anchored component of membrane-IEA-  
GO:0035579specific granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814982Cord blood DNA methylation and adiposity measures in early and mid-childhood. (2017)Kresovich JKClin Epigenetics
20862590Gene expression analysis in induced sputum from welders with and without airway-related symptoms. (2011 Jan)Jonsson LSInt Arch Occup Environ Health