Gene: SFTPB

6439
PSP-B|SFTB3|SFTP3|SMDP1|SP-B
surfactant protein B
protein-coding
2p11.2
Ensembl:ENSG00000168878 MIM:178640 Vega:OTTHUMG00000130181 UniprotKB:P07988
NG_016967.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.891e-1 (AD)  6.413e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPA10.978
SFTPA20.878
SLC34A20.819
CXCL170.707
CSRP30.706
SCGB3A20.696
SCGB1A10.696
KRT70.696
TPO0.667
MTRNR2L30.664

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAGHL-0.345
BOLA1-0.335
C1orf53-0.327
TPGS1-0.327
NT5M-0.322
CLEC11A-0.318
TMEM53-0.317
C17orf49-0.315
DDT-0.314
PEMT-0.312

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SFTPB mRNA"19114083
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SFTPB mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SFTPB mRNA]17585979
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of SFTPB protein14565945
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of SFTPB protein11704537
D000255Adenosine TriphosphateRo 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]11704537
D000638AmiodaroneAmiodarone results in increased metabolism of SFTPB protein25163675
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SFTPB mRNA16483693
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]16490937
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]15083329
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]16863852
D004958EstradiolEstradiol results in increased expression of SFTPB mRNA21398497
C006780bisphenol Abisphenol A results in decreased expression of SFTPB mRNA25181051
D001761BleomycinBleomycin results in decreased expression of SFTPB mRNA15782499
C086232bosentanbosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]15640287
C086232bosentanbosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]15640287
C086232bosentanbosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]15640287
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPB mRNA16997883
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SFTPB mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SFTPB mRNA24982889
D002713ChlorineChlorine affects the expression of SFTPB protein24582687
D002737ChloropreneChloroprene results in increased expression of SFTPB mRNA23125180
D002857ChromiumSFTPB intron polymorphism affects the susceptibility to Chromium16570259
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SFTPB mRNA24374135
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SFTPB mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SFTPB mRNA]17585979
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SFTPB mRNA26033743
D003300CopperCopper deficiency results in increased expression of SFTPB mRNA26033743
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SFTPB mRNA23640034
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPB mRNA16997883
D003907DexamethasoneDexamethasone results in increased expression of SFTPB mRNA16857225|2139849
D003907DexamethasoneDexamethasone results in increased stability of SFTPB mRNA21398497
D003907DexamethasoneThiram inhibits the reaction [Dexamethasone results in increased expression of SFTPB mRNA]16857225
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]10830305
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]10830305|1105115
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]11051153
D003907DexamethasoneDexamethasone results in increased expression of SFTPB mRNA11792629|2335409
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SFTPB mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SFTPB mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of SFTPB mRNA15951333
D002117CalcitriolCalcitriol results in increased expression of SFTPB protein15951333
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SFTPB mRNA"23811387
D019830Adenosine-5'-(N-ethylcarboxamide)Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein14565945
D019830Adenosine-5'-(N-ethylcarboxamide)Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein11704537
D019830Adenosine-5'-(N-ethylcarboxamide)Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]11704537
C074031exenatideexenatide results in increased expression of SFTPB mRNA23354098
D005419FlavonoidsFlavonoids results in increased expression of SFTPB mRNA18035473
C039281furanfuran results in increased methylation of SFTPB gene22079235
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in increased expression of SFTPB mRNA"26833564
D006854HydrocortisoneHydrocortisone results in increased expression of SFTPB mRNA2539393
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SFTPB protein18951874
D015759IonomycinIonomycin results in increased secretion of SFTPB protein14565945
D015759IonomycinIonomycin results in increased secretion of SFTPB protein11704537
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPB mRNA16997883
C045463leflunomideleflunomide results in decreased expression of SFTPB mRNA28988120
D008070LipopolysaccharidesERBB4 protein affects the reaction [Lipopolysaccharides results in decreased expression of SFTPB mRNA]21724861
D008070LipopolysaccharidesERBB4 protein affects the reaction [Lipopolysaccharides results in increased expression of SFTPB protein]21724861
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SFTPB mRNA21724861
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SFTPB protein21724861
D000069450LiraglutideLiraglutide results in increased expression of SFTPB mRNA23354098
D008345ManganeseManganese results in increased expression of SFTPB mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of SFTPB mRNA17175027
D008713MethimazoleMethimazole results in increased expression of SFTPB mRNA22504374
D008727MethotrexateMethotrexate results in decreased expression of SFTPB mRNA17400583
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SFTPB mRNA20153410
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SFTPB mRNA20153410
C496401N-((3-(aminomethyl)phenyl)methyl)ethanimidamide[N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with Phosgene] results in increased expression of SFTPB mRNA25870319
C496401N-((3-(aminomethyl)phenyl)methyl)ethanimidamideN-((3-(aminomethyl)phenyl)methyl)ethanimidamide results in increased expression of SFTPB mRNA25870319
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SFTPB mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SFTPB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased secretion of SFTPB protein"25598225
D009285NaphthoquinonesNaphthoquinones results in increased expression of SFTPB mRNA23811387
D009532NickelNickel results in decreased expression of SFTPB mRNA12540486|1616673
D009532NickelSFTPB protein affects the reaction [Nickel results in decreased expression of MT1 mRNA]16166738
D009532NickelSFTPB protein affects the reaction [Nickel results in decreased expression of MT2 mRNA]16166738
C029938nickel sulfatenickel sulfate affects the expression of SFTPB mRNA12718980
C029938nickel sulfatenickel sulfate results in decreased expression of SFTPB mRNA11893692|1913164
C029938nickel sulfatenickel sulfate results in decreased expression of SFTPB protein11954676
C029938nickel sulfateSFTPB protein affects the susceptibility to nickel sulfate19131640
C029938nickel sulfateTGFA protein inhibits the reaction [nickel sulfate results in decreased expression of SFTPB protein]11954676
D009569Nitric Oxidebosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]15640287
D009569Nitric OxideNitric Oxide results in decreased expression of SFTPB mRNA15640287
D009569Nitric OxidePD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]15640287
D020030Nitric Oxide Donorsbosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]15640287
D020030Nitric Oxide DonorsNitric Oxide Donors results in decreased expression of SFTPB mRNA15640287
D020030Nitric Oxide DonorsPD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]15640287
C007350nitrofenAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]16490937
C007350nitrofenAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]15083329
C007350nitrofennitrofen results in decreased expression of SFTPB mRNA16490937
C007350nitrofennitrofen results in decreased expression of SFTPB protein15083329|1649093
C007350nitrofenVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]16490937
C007350nitrofenVitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]16490937
C007350nitrofennitrofen results in decreased expression of SFTPB mRNA12194114
C007350nitrofenAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]16863852
C007350nitrofenDexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]10830305
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]10830305|1105115
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]11051153
C007350nitrofennitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]10830305
C007350nitrofennitrofen results in decreased expression of SFTPB mRNA10830305|1105115
C007350nitrofennitrofen results in decreased expression of SFTPB protein11051153|1686385
C007350nitrofennitrofen results in increased expression of SFTPB protein17245593
C007350nitrofenNKX2-1 protein affects the reaction [nitrofen results in decreased expression of SFTPB protein]10830305
C007350nitrofenVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]11588001
C007350nitrofenVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]16863852
C007350nitrofenVitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]16863852
D026423S-Nitroso-N-Acetylpenicillaminebosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]15640287
D026423S-Nitroso-N-AcetylpenicillaminePD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]15640287
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA15640287
D010100OxygenOxygen affects the expression of SFTPB mRNA9555576
D010100OxygenOxygen results in decreased expression of SFTPB mRNA16617452
D010100OxygenOxygen results in decreased expression of SFTPB protein16617452
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen results in decreased expression of SFTPB mRNA]16617452
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen results in decreased expression of SFTPB protein]16617452
D010269ParaquatParaquat results in increased expression of SFTPB protein17174135
D010269ParaquatParaquat results in decreased expression of SFTPB mRNA17215068
D052638Particulate MatterIL6 protein promotes the reaction [Particulate Matter results in increased expression of SFTPB mRNA]21494547
D052638Particulate MatterParticulate Matter results in increased expression of SFTPB mRNA21494547
C093321PD 156707PD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]15640287
C093321PD 156707PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]15640287
C093321PD 156707PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]15640287
D010705Phosgene[N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with Phosgene] results in increased expression of SFTPB mRNA25870319
D010936Plant ExtractsPlant Extracts results in decreased expression of SFTPB mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SFTPB mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of SFTPB mRNA21398497
D011441PropylthiouracilPropylthiouracil affects the expression of SFTPB mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of SFTPB mRNA22504374
C059514resveratrolresveratrol results in decreased expression of SFTPB mRNA23224687
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]11704537
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]11704537
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein]11704537
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen results in decreased expression of SFTPB mRNA]16617452
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen results in decreased expression of SFTPB protein]16617452
D013726TerbutalineTerbutaline results in increased expression of SFTPB mRNA2539393
D013726TerbutalineADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]14565945
D013726TerbutalineTerbutaline results in increased secretion of SFTPB protein14565945
D013726TerbutalineTerbutaline results in increased secretion of SFTPB protein11704537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SFTPB mRNA18990726
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of SFTPB protein14565945
D013755Tetradecanoylphorbol AcetateRo 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein]11704537
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of SFTPB protein11704537
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SFTPB protein18951874
D013893ThiramThiram inhibits the reaction [Dexamethasone results in increased expression of SFTPB mRNA]16857225
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SFTPB protein23757602
D014212TretinoinTretinoin results in increased expression of SFTPB mRNA18435480
D014544Uridine TriphosphateUridine Triphosphate results in increased secretion of SFTPB protein14565945
C025643vinclozolinvinclozolin affects the expression of SFTPB mRNA19015723
D014801Vitamin AVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]16490937
D014801Vitamin AVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]11588001
D014801Vitamin AVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]16863852
D014807Vitamin DVitamin D results in increased expression of SFTPB mRNA21398497
D014810Vitamin EVitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]16490937
D014810Vitamin EVitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]16863852

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006665sphingolipid metabolic process-IEA-  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0009887animal organ morphogenesis-TAS10378403  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005764lysosome-IEA-  
GO:0005771multivesicular body-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0042599lamellar body-TAS-  
GO:0045334clathrin-coated endocytic vesicle-TAS-  
GO:0097208alveolar lamellar body-IBA21873635  
GO:0097486multivesicular body lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-5683826Surfactant metabolismTAS
R-HSA-5687613Diseases associated with surfactant metabolismTAS
R-HSA-5688031Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)TAS
R-HSA-5688354Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)TAS
R-HSA-5688849Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)TAS
R-HSA-5688890Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16971405Genetic determinants of C-reactive protein in COPD. (2006 Dec)Hersh CPEur Respir J
24248694Pro-surfactant protein B as a biomarker for lung cancer prediction. (2013 Dec 20)Sin DDJ Clin Oncol
25299874Association of surfactant protein B gene with chronic obstructive pulmonary disease susceptibility. (2014 Nov)Yang JInt J Tuberc Lung Dis
19111454Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. (2009 Apr)Kim WJRespir Med
26813970Serum Glycans as Risk Markers for Non-Small Cell Lung Cancer. (2016 Apr)Ruhaak LRCancer Prev Res (Phila)
28793041Experimental study of peripheral-blood pro-surfactant protein B for screening non-small cell lung cancer. (2017 Jul)He YActa Cir Bras
23897585Circulating pro-surfactant protein B as a risk biomarker for lung cancer. (2013 Oct)Taguchi ACancer Epidemiol Biomarkers Prev