Gene: HHIP

64399
HIP
hedgehog interacting protein
protein-coding
4q31.21
Ensembl:ENSG00000164161 MIM:606178 Vega:OTTHUMG00000161428 UniprotKB:Q96QV1
NG_011496.1
PubMed
0   ANCO-SNPs
ND
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.344e-1 (AD)  5.537e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1440.946
C21orf910.941
ENPP20.932
TRIM590.924
MYRF0.922
C10orf900.921
EVI2A0.921
SLC44A10.92
FOLH10.917
ST180.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SHISA8-0.419
GRIN2D-0.413
CHRNA2-0.404
WTIP-0.399
CUX2-0.394
SLC29A4-0.391
CALB2-0.387
PAX2-0.381
GPR153-0.379
LTK-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HHIP mRNA"26377693
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of HHIP mRNA16788091
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of HHIP mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
D000111Acetylcysteine[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of HHIP mRNA21051528
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HHIP gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HHIP mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HHIP mRNA24449571
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of HHIP mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of HHIP mRNA23912714
D001507BeclomethasoneBeclomethasone results in increased expression of HHIP mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [AHR protein binds to HHIP promoter]19654925
D004958EstradiolEstradiol affects the expression of HHIP mRNA23557687
C006780bisphenol Abisphenol A affects the expression of HHIP mRNA23557687
C006780bisphenol Abisphenol A affects the expression of HHIP mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of HHIP mRNA29275510
D002220CarbamazepineCarbamazepine affects the expression of HHIP mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HHIP mRNA17484886
D002737ChloropreneChloroprene results in increased expression of HHIP mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HHIP gene20938992
D002857ChromiumChromium results in decreased expression of HHIP mRNA21437242
C018021cobaltous chloridecobaltous chloride results in decreased expression of HHIP mRNA19320972
D003042CocaineCocaine results in decreased expression of HHIP mRNA17898221
D003300CopperCopper results in decreased expression of HHIP mRNA26293553
D003471CuprizoneCuprizone results in decreased expression of HHIP mRNA27523638
C017180decamethrindecamethrin results in decreased expression of HHIP mRNA19017407
C014347decitabine[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP mRNA18559595|1855959
C014347decitabine[[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of GLI1 mRNA18559595|1855959
C014347decitabine[[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of PTCH1 mRNA18559595|1855959
C014347decitabinedecitabine results in increased expression of HHIP mRNA27915011
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HHIP mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HHIP mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HHIP mRNA24893172
D004041Dietary FatsDietary Fats results in increased expression of HHIP mRNA21051528
D004041Dietary Fats[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of HHIP mRNA21051528
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of HHIP mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of HHIP mRNA16002434
D000431Ethanol[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of HHIP mRNA21051528
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HHIP mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HHIP mRNA18936297
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HHIP gene20938992
D004397FonofosFonofos results in increased methylation of HHIP promoter22847954
D019833GenisteinGenistein results in decreased expression of HHIP mRNA22553218
D019833GenisteinGenistein results in increased expression of HHIP mRNA21810550
C538724HhAntag691HhAntag691 results in decreased expression of HHIP mRNA24973920
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of HHIP mRNA22129741
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HHIP mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HHIP mRNA24973920
C019003methaneselenolmethaneselenol results in decreased expression of HHIP mRNA19625696
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HHIP gene20938992
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HHIP mRNA23519560
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HHIP mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of HHIP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HHIP mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of HHIP mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of HHIP mRNA27935865
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
D010278ParathionParathion results in increased methylation of HHIP promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of HHIP mRNA27935865
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HHIP mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of HHIP mRNA24780913
C059514resveratrolresveratrol results in decreased expression of HHIP mRNA20878097
C059514resveratrolresveratrol results in increased expression of HHIP mRNA25888808
D012643SeleniumSelenium results in increased expression of HHIP mRNA18997278
C009277sodium arsenatesodium arsenate results in increased expression of HHIP mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of HHIP mRNA23876855
C012568terbufosterbufos results in increased methylation of HHIP promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of HHIP mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HHIP promoter]19654925
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HHIP mRNA23519560
C009495titanium dioxidetitanium dioxide results in increased expression of HHIP mRNA23557971
D014212TretinoinTretinoin results in increased expression of HHIP mRNA18230668
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of HHIP mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of HHIP mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHIP mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of HHIP mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of HHIP mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HHIP gene25560391
D002762CholecalciferolCholecalciferol results in increased expression of HHIP mRNA17170073
C111237vorinostatvorinostat results in increased expression of HHIP mRNA19421011
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of HHIP mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IEA-  
GO:0005515protein binding-IPI19561609  
GO:0008270zinc ion binding-IDA19561609  
GO:0097108hedgehog family protein binding-IBA21873635  
GO:0097108hedgehog family protein binding-IPI19561611  
GO ID GO Term Qualifier Evidence PubMed
GO:0007224smoothened signaling pathway-IEA-  
GO:0007405neuroblast proliferation-IEA-  
GO:0009953dorsal/ventral pattern formation-IEA-  
GO:0009968negative regulation of signal transduction-IDA19561609  
GO:0040036regulation of fibroblast growth factor receptor signaling pathway-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045879negative regulation of smoothened signaling pathway-IBA21873635  
GO:0045879negative regulation of smoothened signaling pathway-ISS11435703  
GO:0048705skeletal system morphogenesis-ISS11435703  
GO:0060441epithelial tube branching involved in lung morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005887integral component of plasma membrane-ISS11435703  
GO:0009986cell surface-IEA-  
GO:0060170ciliary membrane-TAS-  
KEGG ID KEGG Term
hsa04340Hedgehog signaling pathway
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5632681Ligand-receptor interactionsTAS
R-HSA-5632684Hedgehog 'on' stateTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28929109Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease. (2017)Zhang ZBiomed Res Int
22140090Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. (2012 Mar 15)Zhou XHum Mol Genet
28287180Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. (2017 Mar 13)Morrow JDSci Rep
21778810Genetics of COPD. (2011 Sep)Nakamura HAllergol Int
20656943Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. (2010 Dec 15)Pillai SGAm J Respir Crit Care Med
24163739Genetic susceptibility to lung cancer and co-morbidities. (2013 Oct)Yang IAJ Thorac Dis
28566717Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease. (2017 May 31)Wan ESSci Rep
26917578Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. (2016 Jun)Jackson VEThorax
22080838A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (2012 Feb 15)Cho MHHum Mol Genet
25154699Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. (2014 Oct)Lee JHRespir Med
19300482A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. (2009 Mar)Pillai SGPLoS Genet
28248572Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways. (2017 Jul)Yun JHAm J Respir Cell Mol Biol
27612410Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A. (2017 Feb)van der Plaat DAJ Allergy Clin Immunol
28640141Smoking status and gene susceptibility play important roles in the development of chronic obstructive pulmonary disease and lung function decline: A population-based prospective study. (2017 Jun)Zhao JMedicine (Baltimore)
28114305Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls. (2017)Artigas MSPLoS One
21119205Chromosome 4q31 locus in COPD is also associated with lung cancer. (2010 Dec)Young RPEur Respir J