Gene: SFTPC

6440
BRICD6|PSP-C|SFTP2|SMDP2|SP-C
surfactant protein C
protein-coding
8p21.3
Ensembl:ENSG00000168484 MIM:178620 Vega:OTTHUMG00000163775 UniprotKB:P11686
NG_016968.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.030e-1 (AD)  8.371e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TJAP10.66
BOK0.651
JAM30.643
DUOX10.639
BIN10.631
KIAA09300.628
FAM53B0.627
DYSF0.626
CGN0.616
LIPE0.612

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EREG-0.338
TNF-0.306
OR4F29-0.303
DAZL-0.297
CD28-0.297
LBH-0.294
OR4F5-0.293
C15orf53-0.293
DMRT1-0.293
ZNF80-0.289

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide results in increased expression of SFTPC protein26833564
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SFTPC protein15695173
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SFTPC mRNA"18648102
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of SFTPC protein14565945
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of SFTPC protein11704537
D000255Adenosine TriphosphateRo 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]11704537
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SFTPC mRNA19770486
D000638AmiodaroneAmiodarone results in increased metabolism of SFTPC protein25163675
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SFTPC mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in decreased expression of SFTPC mRNA]"19446018
D001205Ascorbic AcidAscorbic Acid results in decreased expression of SFTPC mRNA15372504
C006780bisphenol Abisphenol A results in decreased expression of SFTPC mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SFTPC gene28505145
C086232bosentanbosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]15640287
C086232bosentanbosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]15640287
C086232bosentanbosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]15640287
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPC mRNA16997883
D002922CiguatoxinsCiguatoxins affects the expression of SFTPC mRNA18353800
D005576ColforsinColforsin results in increased expression of SFTPC mRNA2539393
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPC mRNA16997883
D003907DexamethasoneDexamethasone results in increased expression of SFTPC mRNA2539393
D019422Dietary SucroseDietary Sucrose results in increased expression of SFTPC mRNA26033743
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SFTPC mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFTPC mRNA17942748
D019830Adenosine-5'-(N-ethylcarboxamide)Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein14565945
D019830Adenosine-5'-(N-ethylcarboxamide)Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein11704537
D019830Adenosine-5'-(N-ethylcarboxamide)Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]11704537
D004397FonofosFonofos results in increased methylation of SFTPC promoter22847954
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in increased expression of SFTPC mRNA"26833564
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in increased expression of SFTPC protein"26833564
D006854HydrocortisoneHydrocortisone results in increased expression of SFTPC mRNA2539393
D015759IonomycinIonomycin results in increased secretion of SFTPC protein14565945
D015759IonomycinIonomycin results in increased secretion of SFTPC protein11704537
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPC mRNA16997883
C008261lead acetatelead acetate results in decreased expression of SFTPC mRNA21829687
D008070LipopolysaccharidesERBB4 protein affects the reaction [Lipopolysaccharides results in decreased expression of SFTPC mRNA]21724861
D008070LipopolysaccharidesERBB4 protein affects the reaction [Lipopolysaccharides results in increased expression of SFTPC protein]21724861
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SFTPC mRNA21724861
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SFTPC protein21724861
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SFTPC protein28070109
D008070LipopolysaccharidesProtein Kinase Inhibitors inhibits the reaction [Lipopolysaccharides results in decreased expression of SFTPC protein]28070109
D008070Lipopolysaccharidespyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of SFTPC protein]28070109
D015122MercaptopurineMercaptopurine results in increased expression of SFTPC mRNA23358152
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SFTPC mRNA20153410
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SFTPC mRNA20153410
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SFTPC mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SFTPC mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SFTPC mRNA"25620056
D009532NickelNickel results in decreased expression of SFTPC mRNA12540486
C017557nickel subsulfidenickel subsulfide results in decreased expression of SFTPC mRNA21086188
C029938nickel sulfatenickel sulfate affects the expression of SFTPC mRNA12718980
C029938nickel sulfatenickel sulfate results in decreased expression of SFTPC mRNA11893692
D009538NicotineNicotine results in increased expression of SFTPC mRNA9458815
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]9458815
D009569Nitric Oxidebosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]15640287
D009569Nitric OxideNitric Oxide results in decreased expression of SFTPC mRNA15640287
D009569Nitric OxidePD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]15640287
D020030Nitric Oxide Donorsbosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]15640287
D020030Nitric Oxide DonorsNitric Oxide Donors results in decreased expression of SFTPC mRNA15640287
D020030Nitric Oxide DonorsPD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]15640287
C007350nitrofennitrofen results in decreased expression of SFTPC mRNA12194114
C007350nitrofennitrofen results in decreased expression of SFTPC mRNA10751355|1105754
C007350nitrofennitrofen results in decreased expression of SFTPC protein11588001
C007350nitrofennitrofen results in increased expression of SFTPC mRNA12904592|1576464
C007350nitrofenVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPC mRNA]11588001
D026423S-Nitroso-N-Acetylpenicillaminebosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]15640287
D026423S-Nitroso-N-AcetylpenicillaminePD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]15640287
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA15640287
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of SFTPC protein24888373
D010126OzoneOzone results in increased expression of SFTPC protein22727909
D010278ParathionParathion results in increased methylation of SFTPC promoter22847954
C093321PD 156707PD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]15640287
C093321PD 156707PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]15640287
C093321PD 156707PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]15640287
D010936Plant ExtractsPlant Extracts results in decreased expression of SFTPC mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of SFTPC protein24888373
D011441PropylthiouracilPropylthiouracil results in decreased expression of SFTPC mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [Lipopolysaccharides results in decreased expression of SFTPC protein]28070109
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of PRKCZ protein] which results in increased expression of SFTPC protein26833564
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of SFTPC protein]28070109
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]11704537
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]11704537
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein]11704537
C022088silicon carbidesilicon carbide affects the expression of SFTPC mRNA14646272
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SFTPC mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of SFTPC mRNA18685790
C032706sodium chloratesodium chlorate results in decreased expression of SFTPC mRNA12922982
C012568terbufosterbufos results in increased methylation of SFTPC promoter22847954
D013726TerbutalineADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]14565945
D013726TerbutalineTerbutaline results in increased secretion of SFTPC protein14565945
D013726TerbutalineTerbutaline results in increased secretion of SFTPC protein11704537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SFTPC mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFTPC mRNA17942748
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of SFTPC protein14565945
D013755Tetradecanoylphorbol AcetateRo 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein]11704537
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of SFTPC protein11704537
C009495titanium dioxidetitanium dioxide results in decreased expression of SFTPC mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SFTPC protein23757602
D014212TretinoinTretinoin affects the expression of SFTPC mRNA15328022
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]9458815
D014544Uridine TriphosphateUridine Triphosphate results in increased secretion of SFTPC protein14565945
D014635Valproic AcidValproic Acid results in increased methylation of SFTPC gene29154799
D014635Valproic AcidValproic Acid affects the expression of SFTPC mRNA17292431
C025643vinclozolinvinclozolin affects the expression of SFTPC mRNA19015723
C017963vinyl carbamatevinyl carbamate results in increased expression of SFTPC mRNA17849452
D014801Vitamin AVitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPC mRNA]11588001
D014801Vitamin AVitamin A results in decreased expression of SFTPC protein11588001
C009687wortmanninwortmannin results in decreased expression of SFTPC protein15695173
D015032ZincZinc deficiency results in increased expression of SFTPC mRNA19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of SFTPC mRNA]19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19815549  25416956  25910212  26871637  
GO:0042802identical protein binding-IPI25416956  25910212  
GO ID GO Term Qualifier Evidence PubMed
GO:0007585respiratory gaseous exchange-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0042599lamellar body-TAS-  
GO:0045334clathrin-coated endocytic vesicle-TAS-  
GO:0097486multivesicular body lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-5683826Surfactant metabolismTAS
R-HSA-5687613Diseases associated with surfactant metabolismTAS
R-HSA-5688354Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)TAS
R-HSA-5688849Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)TAS
R-HSA-5688890Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17255269Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. (2007 Jan 15)Li RClin Cancer Res
18038590[Polymorphic variants of a surfactant protein C gene in patients with chronic obstructive pulmonary disease]. (2007)Tsvetkova OATer Arkh
20301408Pulmonary Fibrosis, Familial (1993)Talbert JL-