Gene: AKTIP

64400
FT1|FTS
AKT interacting protein
protein-coding
16q12.2
Ensembl:ENSG00000166971 MIM:608483 Vega:OTTHUMG00000133199 UniprotKB:Q9H8T0
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
7.716e-1 (AD)  8.569e-1 (ND)   (Frontal_Cortex)
6.975e-1 (AD)  8.186e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCEAL80.941
CALM20.939
SKP10.939
MFF0.935
MRFAP1L10.932
MORF4L10.932
YWHAQ0.927
FKBP30.926
ENOPH10.926
FAM192A0.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.784
OR4F5-0.779
MTRNR2L6-0.303
MTRNR2L3-0.302
C8orf74-0.295
MTRNR2L10-0.294
KCNJ15-0.281
KLRB1-0.281
FOLR3-0.277
SIX1-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of AKTIP mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of AKTIP mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of AKTIP mRNA"20406850
D000082AcetaminophenAcetaminophen affects the expression of AKTIP mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AKTIP mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AKTIP gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of AKTIP mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AKTIP mRNA24449571
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of AKTIP mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AKTIP mRNA22228805
D004958EstradiolEstradiol results in increased expression of AKTIP mRNA15289156
C006780bisphenol Abisphenol A affects the expression of AKTIP mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of AKTIP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AKTIP gene28505145
C584509C646 compoundC646 compound results in increased expression of AKTIP mRNA26191083
D004390ChlorpyrifosChlorpyrifos results in decreased expression of AKTIP mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AKTIP gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of AKTIP mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of AKTIP mRNA27989131
D003976DiazinonDiazinon results in increased methylation of AKTIP gene22964155
C000944dicrotophosdicrotophos results in decreased expression of AKTIP mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AKTIP mRNA15289156
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of AKTIP mRNA"22485181
D004147DioxinsDioxins affects the expression of AKTIP mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKTIP mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKTIP mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AKTIP mRNA28196854
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AKTIP gene20938992
C039281furanfuran results in increased methylation of AKTIP gene22079235
D019833GenisteinGenistein results in increased expression of AKTIP mRNA15289156
D017313FenretinideFenretinide results in increased expression of AKTIP mRNA28973697
C492448ICG 001ICG 001 results in increased expression of AKTIP mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AKTIP mRNA25613284
C410337K 7174K 7174 results in increased expression of AKTIP mRNA24086573
D007854LeadLead results in increased expression of AKTIP mRNA19921347
C045463leflunomideleflunomide results in decreased expression of AKTIP mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of AKTIP mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AKTIP gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AKTIP mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AKTIP mRNA20061341
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of AKTIP mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AKTIP mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AKTIP mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of AKTIP mRNA25380136
D009532NickelNickel results in decreased expression of AKTIP mRNA23195993
C410127PCB 180PCB 180 results in increased expression of AKTIP mRNA23829299
D010416PentachlorophenolPentachlorophenol results in increased expression of AKTIP mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AKTIP mRNA19162173|2131816
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKTIP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AKTIP mRNA22079256|2271453
D012822Silicon DioxideSilicon Dioxide results in decreased expression of AKTIP mRNA19073995
D012834SilverSilver results in decreased expression of AKTIP mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of AKTIP mRNA23922661
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of AKTIP mRNA26378955
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKTIP mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AKTIP mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of AKTIP protein24648495
D013853ThioacetamideThioacetamide results in increased expression of AKTIP mRNA23411599
D014635Valproic AcidValproic Acid results in increased expression of AKTIP mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of AKTIP mRNA21318169
C025643vinclozolinvinclozolin results in decreased expression of AKTIP mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  18799622  25416956  
GO:0019787ubiquitin-like protein transferase activityNOTNAS18799622  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IDA14749367  
GO:0006915apoptotic process-IEA-  
GO:0007032endosome organization-IMP18799622  
GO:0007040lysosome organization-IMP18799622  
GO:0008333endosome to lysosome transport-IMP18799622  
GO:0015031protein transport-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0032092positive regulation of protein binding-IDA14749367  
GO:0045022early endosome to late endosome transport-IMP18799622  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IDA14749367  
GO:0030897HOPS complexcolocalizes_withIDA18799622  
GO:0070695FHF complex-IDA18799622  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet