Gene info: ID 6441

Gene: SFTPD

GENE ID: 6441

Synonyms: COLEC7|PSP-D|SFTP4|SP-D

Description: surfactant protein D

Gene type: protein-coding

Location: 10q22.3

dbXrefs: Ensembl:ENSG00000133661 MIM:178635 Vega:OTTHUMG00000018590 UniprotKB:P35247

RefSeq: NG_042218.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : 1.262e-1 (AD) 4.488e-1 (ND) (Frontal_Cortex)

Pascal p-value : 3.753e-1 (AD) 8.567e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LYRM9	0.766
MECR	0.737
B9D1	0.722
DNAJC30	0.72
CHCHD6	0.713
CGREF1	0.711
DPCD	0.711
TCTEX1D2	0.71
BFSP1	0.705
KLHL22	0.702

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CNN2	-0.476
KIAA0040	-0.463
WWTR1	-0.463
ANGPT2	-0.463
RAI14	-0.458
PABPC4L	-0.455
CLEC2B	-0.452
LATS2	-0.45
TBX15	-0.448
CARD8	-0.446

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02379	Beta-D-Glucose	Small Molecule	492-61-5	Experimental	Target

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in decreased expression of SFTPD mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SFTPD gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SFTPD mRNA	16483693
D001241	Aspirin	Aspirin results in increased expression of SFTPD mRNA	15456535
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of SFTPD mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of SFTPD mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SFTPD mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SFTPD mRNA	21964900
C020711	beryllium sulfate	beryllium sulfate results in increased expression of SFTPD mRNA	16314022
C006780	bisphenol A	bisphenol A results in decreased expression of SFTPD mRNA	25181051
D001761	Bleomycin	Bleomycin promotes the reaction [SFTPD protein binds to SFTPD protein binds to SFTPD protein]	26526764
D001761	Bleomycin	Bleomycin results in increased metabolism of SFTPD protein	26526764
D001761	Bleomycin	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased metabolism of SFTPD protein]	26526764
D001761	Bleomycin	Bleomycin results in increased expression of SFTPD mRNA	11880309
D001761	Bleomycin	Bleomycin results in increased expression of SFTPD protein	11880309\|2593344
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of SFTPD promoter	22457795
D002713	Chlorine	Chlorine affects the expression of SFTPD protein	24582687
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SFTPD mRNA	20938992
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of SFTPD mRNA	26924002
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of SFTPD mRNA	26924002
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SFTPD mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFTPD mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SFTPD mRNA	17557909
D015025	Zearalenone	Zearalenone results in increased expression of SFTPD mRNA	17557909
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SFTPD mRNA	20938992
C056933	fumonisin B1	fumonisin B1 results in increased expression of SFTPD mRNA	27376354
C039281	furan	furan results in decreased methylation of SFTPD gene	22079235
C039281	furan	furan results in increased expression of SFTPD mRNA	27387713
D019833	Genistein	Genistein results in increased expression of SFTPD mRNA	22553218
D006851	Hydrochloric Acid	Hydrochloric Acid results in decreased expression of SFTPD protein	18573544
D006851	Hydrochloric Acid	Hydrochloric Acid results in increased expression of SFTPD protein	11880309
D006851	Hydrochloric Acid	S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in decreased expression of SFTPD protein]	18573544
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SFTPD mRNA	25613284
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of SFTPD mRNA"	24972896
D008070	Lipopolysaccharides	ERBB4 protein affects the reaction [Lipopolysaccharides results in increased expression of SFTPD mRNA]	21724861
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of SFTPD protein	21724861
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SFTPD mRNA	21724861
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SFTPD mRNA	20938992
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFTPD mRNA	23519560
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of SFTPD mRNA	20153410
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of SFTPD mRNA	20153410
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SFTPD mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of SFTPD protein	20659490
C496401	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased metabolism of SFTPD protein]	26526764
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SFTPD mRNA"	25620056
C028007	nickel monoxide	nickel monoxide analog results in increased expression of SFTPD	21233593
D009566	Nitrates	NOS2 gene mutant form inhibits the reaction [SFTPD gene mutant form results in increased abundance of Nitrates]	24465666
D009566	Nitrates	SFTPD gene mutant form results in increased abundance of Nitrates	24465666
C007350	nitrofen	nitrofen results in decreased expression of SFTPD mRNA	11057544
D010100	Oxygen	Oxygen results in increased expression of SFTPD mRNA	22911455
D010100	Oxygen	[Paraquat co-treated with Oxygen] results in increased expression of SFTPD protein	11880309
D010126	Ozone	Ozone results in increased expression of SFTPD protein	22300504
D010269	Paraquat	Paraquat results in decreased expression of SFTPD protein	17503247
D010269	Paraquat	Paraquat results in decreased expression of SFTPD mRNA	17215068
D010269	Paraquat	[Paraquat co-treated with Oxygen] results in increased expression of SFTPD protein	11880309
D010269	Paraquat	Paraquat results in decreased expression of SFTPD protein	17616020
D010269	Paraquat	Paraquat results in increased expression of SFTPD protein	17616020
D052638	Particulate Matter	Particulate Matter results in increased expression of SFTPD	21233593
D052638	Particulate Matter	Particulate Matter results in increased expression of SFTPD mRNA	27376354
D010795	Phthalic Acids	Phthalic Acids results in increased expression of SFTPD mRNA	21061450
C006253	pirinixic acid	pirinixic acid results in decreased expression of SFTPD mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in decreased expression of SFTPD mRNA	23557933
D011374	Progesterone	Progesterone results in decreased expression of SFTPD mRNA	22238285
D011663	Pulmonary Surfactants	[SFTPD gene mutant form co-treated with NOS2 gene mutant form] results in increased abundance of Pulmonary Surfactants	24465666
D011663	Pulmonary Surfactants	SFTPD gene mutant form results in increased abundance of Pulmonary Surfactants	24465666
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of SFTPD mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SFTPD mRNA	18685790\|2243100
C027744	S-methylisothiopseudouronium	S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in decreased expression of SFTPD protein]	18573544
C027744	S-methylisothiopseudouronium	S-methylisothiopseudouronium inhibits the reaction [Sucralfate results in decreased expression of SFTPD protein]	18573544
C017947	sodium arsenite	sodium arsenite results in increased expression of SFTPD mRNA	28229933
D053260	Soot	Soot results in increased expression of SFTPD mRNA	26551751
D013392	Sucralfate	S-methylisothiopseudouronium inhibits the reaction [Sucralfate results in decreased expression of SFTPD protein]	18573544
D013392	Sucralfate	Sucralfate results in decreased expression of SFTPD protein	18573544
D013726	Terbutaline	[Terbutaline co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SFTPD protein	9476903
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SFTPD mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFTPD mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SFTPD mRNA	18990726
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFTPD mRNA	23519560
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SFTPD mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	[Terbutaline co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SFTPD protein	9476903
C009495	titanium dioxide	titanium dioxide results in decreased expression of SFTPD mRNA	23131501
C009495	titanium dioxide	titanium dioxide results in increased expression of SFTPD mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SFTPD protein	22659316
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of SFTPD protein	26609137
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of SFTPD mRNA"	11379042
D014212	Tretinoin	Tretinoin results in increased expression of SFTPD mRNA	16965567
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of SFTPD gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of SFTPD mRNA	27376354
C025643	vinclozolin	vinclozolin affects the expression of SFTPD mRNA	19015723

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001530	lipopolysaccharide binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	12884308 28228557
GO:0030246	carbohydrate binding	-	TAS	10485905
GO:0042802	identical protein binding	-	IEA	-
GO:0048029	monosaccharide binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001817	regulation of cytokine production	-	NAS	9751757
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0006898	receptor-mediated endocytosis	-	TAS	10485905
GO:0007585	respiratory gaseous exchange	-	IEA	-
GO:0032502	developmental process	-	IBA	21873635
GO:0042130	negative regulation of T cell proliferation	-	TAS	10485905
GO:0042742	defense response to bacterium	-	TAS	9751757
GO:0043129	surfactant homeostasis	-	IBA	21873635
GO:0043129	surfactant homeostasis	-	IMP	9751757
GO:0043152	induction of bacterial agglutination	-	IMP	28228557
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045085	negative regulation of interleukin-2 biosynthetic process	-	TAS	10485905
GO:0045087	innate immune response	-	TAS	10485905
GO:0048246	macrophage chemotaxis	-	TAS	10485905
GO:0048286	lung alveolus development	-	IMP	9751757
GO:0050766	positive regulation of phagocytosis	-	IBA	21873635
GO:0050766	positive regulation of phagocytosis	-	TAS	10485905
GO:0050776	regulation of immune response	-	TAS	-
GO:0052405	negative regulation by host of symbiont molecular function	-	IDA	28228557
GO:0072593	reactive oxygen species metabolic process	-	TAS	10485905
GO:1905226	regulation of adhesion of symbiont to host epithelial cell	-	IDA	28228557

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	9751757
GO:0005581	collagen trimer	-	IEA	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IEA	-
GO:0005764	lysosome	-	TAS	10485905
GO:0005771	multivesicular body	-	IBA	21873635
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005791	rough endoplasmic reticulum	-	IBA	21873635
GO:0030139	endocytic vesicle	-	TAS	10485905
GO:0045334	clathrin-coated endocytic vesicle	-	TAS	-

KEGG ID	KEGG Term
hsa04145	Phagosome

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-391160	Signal regulatory protein family interactions	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5668914	Diseases of metabolism	TAS
R-HSA-5683826	Surfactant metabolism	TAS
R-HSA-5686938	Regulation of TLR by endogenous ligand	TAS
R-HSA-5687613	Diseases associated with surfactant metabolism	TAS
R-HSA-5687868	Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)	TAS
R-HSA-5688849	Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	TAS
R-HSA-5688890	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20448057	Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. (2011 Mar)	Foreman MG	Am J Respir Cell Mol Biol
23144326	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (2012 Dec 15)	Kim DK	Am J Respir Crit Care Med
24264011	Smoking and polymorphisms of genes encoding mannose-binding lectin and surfactant protein-D in patients with rheumatoid arthritis. (2014 Mar)	Kristiansen M	Rheumatol Int
19140875	The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease. (2009 Jan)	Berg KK	Scand J Immunol