Gene: SYCE3

644186
C22orf41|THEG2
synaptonemal complex central element protein 3
protein-coding
22q13.33
Ensembl:ENSG00000217442 MIM:615775 Vega:OTTHUMG00000150273 UniprotKB:A1L190
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.012e-1 (AD)  7.192e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A10.459
ACY10.455
GGACT0.439
FXYD10.432
MASP10.426
HSD17B80.42
MTHFS0.416
RARRES20.414
APOM0.409
PPP1R14B0.403

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF10-0.301
GPR52-0.286
HSFY2-0.276
MAS1-0.275
HTR1B-0.275
SH3D21-0.272
PROKR2-0.269
ZFP69B-0.268
PROX2-0.267
ROPN1L-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A affects the expression of SYCE3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SYCE3 gene28505145
D004041Dietary FatsDietary Fats results in decreased expression of SYCE3 mRNA25016146
C039281furanfuran results in increased expression of SYCE3 mRNA25539665|2619464
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SYCE3 mRNA25895662
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SYCE3 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SYCE3 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of SYCE3 gene29154799
C111237vorinostatvorinostat results in increased expression of SYCE3 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007130synaptonemal complex assembly-IBA21873635  
GO:0007130synaptonemal complex assembly-ISS-  
GO:0007131reciprocal meiotic recombination-IBA21873635  
GO:0007131reciprocal meiotic recombination-ISS-  
GO:0007283spermatogenesis-ISS-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000801central element-IBA21873635  
GO:0000801central element-ISS-  
GO:0005634nucleus-ISS-  
GO:0005694chromosome-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28149327In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. (2017)Chatterton ZEpigenetics Chromatin