Gene: DNAI2

64446
CILD9|DIC2
dynein axonemal intermediate chain 2
protein-coding
17q25.1
Ensembl:ENSG00000171595 MIM:605483 Vega:OTTHUMG00000178578 UniprotKB:Q9GZS0
NG_016865.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.759e-1 (AD)  5.883e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH30.698
GSC0.683
PIRT0.655
AGTR10.645
IGF2BP20.626
S100A30.623
LHX50.622
CRNDE0.615
IRX20.614
ZNF1140.612

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCKBR-0.523
GABRD-0.523
MPPED1-0.522
KCNJ4-0.522
STAC2-0.517
CHRM1-0.515
TESPA1-0.514
PVALB-0.507
NEUROD6-0.504
EMX1-0.503

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of DNAI2 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of DNAI2 mRNA28959563
D001151ArsenicArsenic affects the methylation of DNAI2 gene25304211
C006780bisphenol Abisphenol A results in decreased expression of DNAI2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of DNAI2 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of DNAI2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of DNAI2 mRNA26577399
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of DNAI2 mRNA25198161
D005557FormaldehydeFormaldehyde results in increased expression of DNAI2 mRNA23649840
D011441PropylthiouracilPropylthiouracil affects the expression of DNAI2 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of DNAI2 protein28918527
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DNAI2 mRNA25788831|2786577
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of DNAI2 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IMP11153919  
GO:0005515protein binding-IPI25232951  
GO:0008574ATP-dependent microtubule motor activity, plus-end-directedCONTRIBUTES_TOIBA21873635  
GO:0045503dynein light chain binding-IBA21873635  
GO:0045504dynein heavy chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0003341cilium movement-IBA21873635  
GO:0003341cilium movement-IMP18950741  23261302  
GO:0007018microtubule-based movement-IBA21873635  
GO:0007368determination of left/right symmetry-IMP18950741  
GO:0036158outer dynein arm assembly-IBA21873635  
GO:0036158outer dynein arm assembly-IMP18950741  23261302  
GO:0060271cilium assembly-IMP11153919  
GO ID GO Term Qualifier Evidence PubMed
GO:0005858axonemal dynein complex-IMP11153919  
GO:0005874microtubule-IEA-  
GO:0005930axoneme-IDA18950741  23849778  
GO:0005930axoneme-IMP11153919  
GO:0009897external side of plasma membrane-IEA-  
GO:0030286dynein complex-IBA21873635  
GO:0036126sperm flagellum-IDA18950741  
GO:0036157outer dynein arm-IBA21873635  
GO:0036157outer dynein arm-IMP18950741  
KEGG ID KEGG Term
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16809635Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. (2006 Dec)Lonergan KMAm J Respir Cell Mol Biol