Gene info: ID 6446

Gene: SGK1

GENE ID: 6446

Synonyms: SGK

Description: serum/glucocorticoid regulated kinase 1

Gene type: protein-coding

Location: 6q23.2

dbXrefs: Ensembl:ENSG00000118515 MIM:602958 Vega:OTTHUMG00000015613 UniprotKB:O00141

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.597e-1 (AD) 2.473e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM165	0.85
PRIMA1	0.82
SLAIN1	0.813
RTKN	0.81
ADIPOR2	0.808
FAM84B	0.806
CDH19	0.802
BEST1	0.792
CHRAC1	0.792
RHOG	0.789

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
VIP	-0.371
CUX2	-0.366
CHRNA2	-0.361
FBLN7	-0.349
KCNQ4	-0.347
FREM3	-0.346
OR4F5	-0.344
KAZALD1	-0.342
CDH22	-0.328
OR4F29	-0.328

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03247	Flavin mononucleotide	Small Molecule	146-17-8	Approved\|Investigational	Target
DB07837	[4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid	Small Molecule		Experimental	Target
DB08191	4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C003552	11-dehydrocorticosterone	11-dehydrocorticosterone results in increased expression of SGK1 mRNA	16533503
C003552	11-dehydrocorticosterone	Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]	16533503
C003552	11-dehydrocorticosterone	Tetradecanoylphorbol Acetate promotes the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]	16533503
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SGK1 mRNA"	21354444
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SGK1 mRNA	28329830
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of SGK1 protein"	21407213
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SGK1 mRNA"	25614096
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SGK1 mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SGK1 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SGK1 mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of SGK1 protein	15679045
C530773	3,5-diethoxycarbonyl-1,4-dihydrocollidine	"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein"	23620592
C530773	3,5-diethoxycarbonyl-1,4-dihydrocollidine	"CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]"	23620592
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of SGK1 mRNA	14610520
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of SGK1 mRNA"	25912373
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of SGK1 mRNA	19191707
C029370	4-toluidine	4-toluidine results in decreased expression of SGK1 mRNA	27638505
C546624	(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	"(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol results in decreased phosphorylation of SGK1 protein"	21407213
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of SGK1 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of SGK1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SGK1 mRNA]	17585979
D020106	Acrylamide	Acrylamide results in increased expression of SGK1 mRNA	28959563
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of SGK1 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SGK1 protein	20106945
D000450	Aldosterone	Aldosterone results in decreased expression of SGK1 protein	22798426
D000450	Aldosterone	TSG101 mutant form inhibits the reaction [Aldosterone results in decreased expression of SGK1 protein]	22798426
D000450	Aldosterone	Aldosterone results in increased expression of SGK1 mRNA	15130897\|1942993
D000450	Aldosterone	Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]	19429930
D000450	Aldosterone	Aldosterone results in increased expression of SGK1	24269741
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of SGK1 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SGK1 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of SGK1 protein	16483693
D000661	Amphetamine	Amphetamine results in increased expression of SGK1 mRNA	12638131
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SGK1 mRNA	24449571
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of SGK1 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of SGK1 mRNA	23912714
D001151	Arsenic	Arsenic inhibits the reaction [SGK1 protein results in increased activity of CFTR protein]	20207026
D001151	Arsenic	Arsenic results in decreased expression of SGK1 mRNA	20207026
D001151	Arsenic	Arsenic results in decreased expression of SGK1 protein	20207026
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SGK1 mRNA	18231732\|2435693
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SGK1 mRNA"	18687144
D001280	Atrazine	Atrazine results in increased expression of SGK1 mRNA	18461179\|2237831
D001280	Atrazine	SGK1 protein affects the reaction [Atrazine results in increased expression of CYP11A1 mRNA]	18461179
D001280	Atrazine	SGK1 protein affects the reaction [Atrazine results in increased expression of CYP19A1 mRNA]	18461179
D001280	Atrazine	SGK1 protein affects the reaction [Atrazine results in increased expression of HSD11B2 mRNA]	18461179
D001280	Atrazine	SGK1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA]	18461179
D001379	Azathioprine	Azathioprine results in decreased expression of SGK1 mRNA	22623647
D001464	Barium	Barium inhibits the reaction [SGK1 protein results in increased transport of Potassium]	12590200
D001507	Beclomethasone	Beclomethasone results in increased expression of SGK1 mRNA	23656298
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in decreased expression of SGK1 mRNA	24356939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SGK1 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SGK1 mRNA	19770486\|2171566
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SGK1 mRNA	21569818\|2719552
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SGK1 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SGK1 mRNA"	20018196
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SGK1 mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with EGF protein] results in increased expression of SGK1 mRNA	24758408
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SGK1 mRNA	19619570
D004958	Estradiol	Estradiol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNA]	21056929
D004958	Estradiol	Estradiol results in decreased expression of SGK1 mRNA	20106945\|2105692
D004958	Estradiol	Estradiol results in increased expression of SGK1 mRNA	16202921\|1961957
D004958	Estradiol	Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of SGK1 mRNA]	24758408
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of SGK1 mRNA]	24758408
D004958	Estradiol	Estradiol affects the expression of SGK1 mRNA	15598610
D004958	Estradiol	Estradiol results in decreased expression of SGK1 mRNA	28476547
D004958	Estradiol	Estradiol results in decreased expression of SGK1 protein	28476547
D004958	Estradiol	Estradiol results in increased expression of SGK1 mRNA	25210133
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of SGK1 mRNA	26496021
C006780	bisphenol A	bisphenol A affects the expression of SGK1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of SGK1 mRNA	27685785\|2871154
C006780	bisphenol A	bisphenol A results in decreased expression of SGK1 mRNA	24586524
C006780	bisphenol A	bisphenol A results in decreased expression of SGK1 mRNA	25594700\|2847654
C006780	bisphenol A	bisphenol A results in decreased expression of SGK1 protein	28476547
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of SGK1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of SGK1 mRNA	12075121\|2518105
C006780	bisphenol A	bisphenol A results in increased methylation of SGK1 gene	28505145
C025703	bleomycetin	bleomycetin results in increased expression of SGK1 mRNA	21040473
D000069286	Bortezomib	Bortezomib results in increased expression of SGK1 mRNA	20977926
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNA	21056929
D015124	8-Bromo Cyclic Adenosine Monophosphate	Estradiol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNA]	21056929
D015124	8-Bromo Cyclic Adenosine Monophosphate	Genistein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNA]	21056929
D002065	Buspirone	Buspirone results in decreased expression of SGK1 mRNA	24136188
C584509	C646 compound	C646 compound results in increased expression of SGK1 mRNA	26191083
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of SGK1 mRNA	16122865
D002104	Cadmium	Cadmium results in increased expression of SGK1 mRNA	21694771
D002104	Cadmium	Cadmium results in increased expression of SGK1 mRNA	17327699
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of and results in increased phosphorylation of SGK1 protein	25128767
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SGK1 mRNA	25128767
D019256	Cadmium Chloride	Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 protein]	25128767
D019256	Cadmium Chloride	Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 mRNA]	25128767
D019256	Cadmium Chloride	Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 protein]	25128767
D019256	Cadmium Chloride	SGK1 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of NDRG1 protein]	25128767
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SGK1 mRNA	12634122
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SGK1 mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of SGK1 mRNA	18974090
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SGK1 mRNA	25993096
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SGK1 mRNA	17327699
C037123	cadmium sulfate	cadmium sulfate results in decreased expression of SGK1 mRNA	21783983
D000074262	Canola Oil	Canola Oil metabolite results in increased expression of SGK1 mRNA	27363782
D000074262	Canola Oil	Starch analog inhibits the reaction [Canola Oil metabolite results in increased expression of SGK1 mRNA]	27363782
D002220	Carbamazepine	Carbamazepine affects the expression of SGK1 mRNA	25979313
D002229	Carbenoxolone	Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]	16533503
D002229	Carbenoxolone	Carbenoxolone results in decreased activity of SGK1 protein	16533503
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SGK1 mRNA	27339419
C010063	carbonyl sulfide	carbonyl sulfide results in decreased expression of SGK1 mRNA	19395590
D002273	Carcinogens	Carcinogens results in increased expression of SGK1 mRNA	16316942
D002713	Chlorine	Chlorine results in decreased expression of SGK1 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of SGK1 mRNA	18636392
C100187	chloropicrin	chloropicrin results in increased expression of SGK1 mRNA	26352163
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of SGK1 mRNA	25424538
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SGK1 mRNA	12634122
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of SGK1 mRNA	28472532
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SGK1 mRNA	12634122
C418118	CI 1044	CI 1044 results in increased expression of SGK1 mRNA	17569694
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of SGK1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of SGK1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SGK1 mRNA]	17585979
D002996	Clomiphene	Clomiphene results in decreased expression of SGK1 mRNA	26865669
D003024	Clozapine	Clozapine results in increased expression of SGK1 mRNA	17266109
D003024	Clozapine	Clozapine results in increased expression of SGK1 mRNA	18208916
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in decreased expression of SGK1 mRNA	18078969
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SGK1 mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of SGK1 mRNA	20187946
D003078	Colchicine	Colchicine results in decreased expression of SGK1 mRNA	24211769
D003300	Copper	Copper results in increased expression of SGK1 mRNA	24403277
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in increased expression of SGK1 mRNA	25167922
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SGK1 mRNA	19549813
D003345	Corticosterone	Corticosterone results in increased expression of SGK1 mRNA	21655274
D003345	Corticosterone	Corticosterone results in increased expression of SGK1 protein	21655274
D003345	Corticosterone	[Corticosterone results in increased phosphorylation of and results in increased activity of PDK1 protein] which results in increased phosphorylation of and results in increased activity of SGK1 protein	21655274
D003345	Corticosterone	[Corticosterone results in increased phosphorylation of SGK1 protein] which results in increased phosphorylation of NDRG1 protein	21655274
D003345	Corticosterone	Corticosterone results in increased expression of SGK1 mRNA	15755911
D003348	Cortisone	Cortisone results in increased expression of SGK1 mRNA	16533503
D003348	Cortisone	Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]	16533503
D003348	Cortisone	Tetradecanoylphorbol Acetate promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]	16533503
D003471	Cuprizone	Cuprizone results in increased expression of SGK1 mRNA	27523638
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 protein]	25128767
D003520	Cyclophosphamide	Cyclophosphamide metabolite results in decreased expression of SGK1 mRNA	24356939
D016572	Cyclosporine	Cyclosporine results in decreased expression of SGK1 mRNA	20106945\|2163298
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 mRNA]	25128767
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 protein]	25128767
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SGK1 mRNA	24317228
C014347	decitabine	[decitabine co-treated with vorinostat] affects the expression of SGK1 mRNA	17330099
D013759	Dronabinol	Dronabinol results in increased expression of SGK1 mRNA	21955143
D003703	Demecolcine	Demecolcine results in increased expression of SGK1 mRNA	23649840
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SGK1 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of SGK1 mRNA	15679045\|1769013
D003907	Dexamethasone	Dexamethasone results in increased expression of SGK1 protein	15679045
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	17690134
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SGK1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of and results in increased phosphorylation of SGK1 protein	21655274
D003907	Dexamethasone	Dexamethasone results in increased expression of SGK1 mRNA	15793248\|1934407
D003907	Dexamethasone	Dexamethasone results in increased expression of SGK1 protein	15793248
D003907	Dexamethasone	[Dexamethasone results in increased phosphorylation of SGK1 protein] promotes the reaction [SGK1 protein binds to and results in increased phosphorylation of NDRG1 protein]	21655274
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	29222744
D003907	Dexamethasone	trichostatin A inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	23946490
D003907	Dexamethasone	Valproic Acid inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	23946490
D003907	Dexamethasone	wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of SGK1 protein]	21655274
D003907	Dexamethasone	Dexamethasone results in decreased expression of SGK1 mRNA	14618091
D003907	Dexamethasone	Dexamethasone results in increased expression of SGK1 mRNA	15793248\|1769013
D003907	Dexamethasone	Dexamethasone results in increased expression of SGK1 protein	15793248
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	15793248\|1769013
D003907	Dexamethasone	CARM1 protein inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]]	19707557
D003907	Dexamethasone	Dexamethasone results in increased expression of SGK1 mRNA	19707557
D003907	Dexamethasone	sodium arsenite inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	19707557
D003993	Dibutyl Phthalate	Dibutyl Phthalate affects the expression of SGK1 mRNA	21745491
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SGK1 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SGK1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of SGK1 mRNA	21151649
C000944	dicrotophos	dicrotophos results in increased expression of SGK1 mRNA	28302478
D004026	Dieldrin	Dieldrin affects the expression of SGK1 mRNA	22546817
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of SGK1 mRNA	17490981
D004041	Dietary Fats	Dietary Fats results in decreased expression of SGK1 mRNA	18042831
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SGK1 mRNA	26865669
D002117	Calcitriol	Calcitriol results in decreased expression of SGK1 mRNA	16002434
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in increased expression of SGK1 mRNA"	27840820
D004147	Dioxins	Dioxins affects the expression of SGK1 mRNA	20463971
D004237	Diuron	Diuron results in increased expression of SGK1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in increased expression of SGK1 protein	18768591
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of SGK1 mRNA	20064776
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SGK1 mRNA	22079256
D004970	Estrone	Estrone results in increased expression of SGK1 mRNA	26865669
D000431	Ethanol	Ethanol promotes the reaction [NR3C1 protein binds to SGK1 promoter]	23991167
D000431	Ethanol	Ethanol results in decreased expression of SGK1 protein	23991167
D000431	Ethanol	Ethanol results in increased expression of SGK1 mRNA	21955143\|2399116
D000431	Ethanol	Ethanol results in increased phosphorylation of and results in increased activity of SGK1 protein	23991167
D000431	Ethanol	[Ethanol results in increased phosphorylation of and results in increased activity of SGK1 protein] which results in increased phosphorylation of NDRG1 protein	23991167
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SGK1 mRNA	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SGK1 mRNA	12075121
D008656	Mestranol	Mestranol results in increased expression of SGK1 mRNA	26865669
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of SGK1 mRNA	24211769
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of SGK1 mRNA	23649840
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of SGK1 mRNA	15954086
C422415	farglitazar	farglitazar results in increased expression of SGK1 mRNA	15475592
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SGK1 mRNA	28329830
D005473	Fluoxetine	Fluoxetine results in increased expression of SGK1 mRNA	17033635
C061365	flusilazole	flusilazole results in increased expression of SGK1 mRNA	22382673
C065180	fluvastatin	fluvastatin affects the expression of SGK1 mRNA	16696316
C065180	fluvastatin	fluvastatin affects the expression of SGK1 protein	16696316
D005557	Formaldehyde	Formaldehyde results in increased expression of SGK1 mRNA	17938736\|2065599
D005632	Fructose	Fructose results in increased expression of SGK1 mRNA	16284089
D005632	Fructose	"SGK1 gene affects the susceptibility to [Fructose co-treated with Sodium Chloride, Dietary]"	16284089
C408042	fullerol C60(OH)24	fullerol C60(OH)24 results in decreased expression of SGK1 mRNA	21513982
C070081	fulvestrant	fulvestrant results in decreased expression of SGK1 mRNA	26865669
C039281	furan	furan results in decreased expression of SGK1 mRNA	26194646
C039281	furan	furan results in increased expression of SGK1 mRNA	27387713
D019833	Genistein	Genistein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNA]	21056929
D019833	Genistein	Genistein results in decreased expression of SGK1 mRNA	21056929
D019833	Genistein	Genistein results in increased expression of SGK1 mRNA	26865669
D019833	Genistein	Genistein results in increased expression of SGK1 mRNA	12075121\|2178274
D005839	Gentamicins	Gentamicins results in increased expression of SGK1 mRNA	22061828
D005944	Glucosamine	Glucosamine results in decreased expression of SGK1 mRNA	17178593
D005947	Glucose	Glucose results in increased expression of SGK1 mRNA	17178593
D006220	Haloperidol	Haloperidol results in increased expression of SGK1 mRNA	16452686
D006589	Hexestrol	Hexestrol results in increased expression of SGK1 mRNA	26865669
D017313	Fenretinide	Fenretinide results in increased expression of SGK1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SGK1 mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SGK1 mRNA	29110037
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of SGK1 protein	15795328
D006918	Hydroxyurea	Hydroxyurea results in increased expression of SGK1 mRNA	18647660
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime results in decreased activity of SGK1 protein	12534346
D007213	Indomethacin	Indomethacin results in decreased expression of SGK1 mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SGK1 mRNA	25613284
C051890	irinotecan	irinotecan analog results in increased expression of SGK1 mRNA	18927307
C051890	irinotecan	irinotecan metabolite results in increased expression of SGK1 mRNA	15956246
C051890	irinotecan	irinotecan results in increased expression of SGK1 mRNA	15956246\|2018591
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SGK1 mRNA	16054899
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SGK1 mRNA	27392435
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SGK1 mRNA	12634122
C008261	lead acetate	lead acetate results in decreased expression of SGK1 mRNA	25270620
C008261	lead acetate	lead acetate results in increased expression of SGK1 mRNA	22641619
D001556	Lindane	Lindane results in increased expression of SGK1 mRNA	24356939
D001556	Lindane	Lindane results in decreased expression of SGK1 mRNA	17785943
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of SGK1 mRNA	25613284
C025340	manganese chloride	manganese chloride results in decreased expression of SGK1 mRNA	20737472
C025340	manganese chloride	manganese chloride results in decreased expression of SGK1 protein	20737472
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of SGK1 mRNA	18497975
D008558	Melphalan	Melphalan results in increased expression of SGK1 mRNA	22363485
C000600817	mercaptosteroid 6	mercaptosteroid 6 results in increased expression of SGK1 mRNA	25851902
C042720	mercuric bromide	mercuric bromide results in increased expression of SGK1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of SGK1 mRNA	20353558
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of SGK1 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of SGK1 mRNA	19564919
C036868	methyl carbamate	methyl carbamate results in decreased expression of SGK1 mRNA	29110037
C002950	methylformamide	methylformamide analog results in increased expression of SGK1 mRNA	17040096
C002950	methylformamide	methylformamide results in increased expression of SGK1 mRNA	17040096
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SGK1 mRNA	17961207\|2018165
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SGK1 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SGK1 mRNA	24211769
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SGK1 mRNA"	20188158
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SGK1 mRNA"	20188158
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of SGK1 mRNA	29110037
C008493	methylselenic acid	methylselenic acid affects the expression of SGK1 mRNA	14617803
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	17690134
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	29222744
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	15793248\|1769013
D016685	Mitomycin	Mitomycin promotes the reaction [TP53 protein results in increased expression of SGK1 mRNA]	18647660
D016685	Mitomycin	Mitomycin results in decreased expression of SGK1 mRNA	24211769
D016685	Mitomycin	Mitomycin results in increased expression of SGK1 mRNA	18647660
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of SGK1 mRNA	22401849
D009020	Morphine	Morphine results in increased expression of SGK1 mRNA	21955143
D009151	Mustard Gas	Mustard Gas affects the expression of SGK1 mRNA	15651846
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of SGK1 protein	10998351
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SGK1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SGK1 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of SGK1 mRNA	18978301
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of SGK1 mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of SGK1 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of SGK1 mRNA	24084258
C028007	nickel monoxide	nickel monoxide results in increased expression of SGK1 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of SGK1 mRNA	16780908\|2271453
D009538	Nicotine	Nicotine results in increased expression of SGK1 mRNA	17456735\|2195514
C012655	nimesulide	nimesulide results in decreased expression of SGK1 mRNA	24136188
C025589	ochratoxin A	ochratoxin A metabolite results in decreased expression of SGK1 mRNA	24356939
C025589	ochratoxin A	ochratoxin A results in decreased expression of SGK1 mRNA	24356939
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in increased expression of SGK1 mRNA	25167922
D009966	Orphenadrine	Orphenadrine affects the expression of SGK1 mRNA	23665939
D010100	Oxygen	Oxygen results in increased expression of and results in increased phosphorylation of SGK1 protein	15795328
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of SGK1 mRNA	18636392
D010126	Ozone	Ozone results in increased expression of SGK1 mRNA	23805001
D017239	Paclitaxel	Paclitaxel results in decreased expression of SGK1 mRNA	15585946
D000073878	Palm Oil	Palm Oil results in decreased expression of SGK1 mRNA	18042831
D010269	Paraquat	Paraquat results in increased expression of SGK1 mRNA	12595580
D052638	Particulate Matter	Particulate Matter results in decreased expression of SGK1 mRNA	22178795
D052638	Particulate Matter	Particulate Matter results in increased expression of SGK1 mRNA	23805001
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of SGK1 mRNA	19162173
D010622	Phencyclidine	Phencyclidine results in increased expression of SGK1 mRNA	17266109
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SGK1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of SGK1 mRNA	19482888
D010656	Phenylephrine	Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]	16533503
D010656	Phenylephrine	Phenylephrine results in increased phosphorylation of SGK1 protein	15795328
D010656	Phenylephrine	SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]	15795328
D010656	Phenylephrine	SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]	15795328
D010656	Phenylephrine	SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]	15795328
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SGK1 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of SGK1 mRNA	15728792
C006253	pirinixic acid	pirinixic acid results in increased expression of SGK1 mRNA	17426115\|1844570
C006253	pirinixic acid	pirinixic acid results in decreased expression of SGK1 mRNA	12832660\|1916217
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of SGK1 mRNA	21334430
D011188	Potassium	Barium inhibits the reaction [SGK1 protein results in increased transport of Potassium]	12590200
D011188	Potassium	Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]	12590200
D011188	Potassium	SGK1 protein results in increased transport of Potassium	12590200
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SGK1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of SGK1 mRNA	22714537
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of SGK1 mRNA	22079256
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of SGK1 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SGK1 mRNA	19162173
C009041	primycin	primycin results in increased expression of SGK1 mRNA	28916286
D011374	Progesterone	Progesterone results in increased expression of SGK1 mRNA	18070364
D011374	Progesterone	Progesterone results in increased expression of SGK1 mRNA	20726854
D011374	Progesterone	Progesterone results in decreased expression of SGK1	17510236
C045950	propiconazole	propiconazole results in increased expression of SGK1 mRNA	19363144\|2127805
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SGK1 mRNA	24780913
C432165	pyrazolanthrone	pyrazolanthrone results in decreased activity of SGK1 protein	12534346
D011794	Quercetin	Quercetin results in decreased expression of SGK1 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of SGK1 mRNA	14699072
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SGK1 mRNA	19059307
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of SGK1 mRNA	26865669
C488333	Ro 65-7199	Ro 65-7199 affects the expression of SGK1 mRNA	14610520
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SGK1 mRNA	16054899
D012402	Rotenone	Rotenone results in increased expression of SGK1 mRNA	27900601
D012524	Sarin	Sarin results in decreased expression of SGK1 mRNA	19522546
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of SGK1 mRNA	19564919
C534628	SCH 23390	SCH 23390 results in increased expression of SGK1 mRNA	19564919
C009250	sevoflurane	sevoflurane affects the expression of SGK1 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SGK1 mRNA	25895662
D012834	Silver	Silver results in decreased expression of SGK1 mRNA	26014281
C009277	sodium arsenate	sodium arsenate results in increased expression of SGK1 mRNA	23922661
C017947	sodium arsenite	sodium arsenite inhibits the reaction [SGK1 protein results in increased activity of CFTR protein]	20207026
C017947	sodium arsenite	sodium arsenite results in decreased expression of SGK1 mRNA	20207026
C017947	sodium arsenite	sodium arsenite results in decreased expression of SGK1 protein	20207026
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SGK1 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in decreased expression of SGK1 mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in decreased expression of SGK1 mRNA	25270620
C017947	sodium arsenite	CARM1 protein inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]]	19707557
C017947	sodium arsenite	sodium arsenite inhibits the reaction [CARM1 protein binds to SGK1 promoter]	19707557
C017947	sodium arsenite	sodium arsenite inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	19707557
C016104	sodium bichromate	sodium bichromate results in decreased expression of SGK1 mRNA	22561333
D017673	Sodium Chloride, Dietary	"SGK1 gene affects the susceptibility to [Fructose co-treated with Sodium Chloride, Dietary]"	16284089
D053260	Soot	Soot affects the expression of SGK1 mRNA	26551751
D013148	Spironolactone	Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]	19429930
D013213	Starch	Starch analog inhibits the reaction [Canola Oil metabolite results in increased expression of SGK1 mRNA]	27363782
D013311	Streptozocin	Streptozocin results in increased expression of SGK1 mRNA	16116964
D013311	Streptozocin	Streptozocin results in increased expression of SGK1 protein	16116964
D010042	Ouabain	Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]	12590200
D010042	Ouabain	Ouabain results in decreased expression of SGK1 mRNA	28795476
C016766	sulforafan	sulforafan results in increased expression of SGK1 mRNA	26833863
D013629	Tamoxifen	[Tamoxifen co-treated with ESR1 protein] results in increased expression of SGK1 mRNA	19059307
D013629	Tamoxifen	Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of SGK1 mRNA]	24758408
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of SGK1 mRNA]	24758408
D013739	Testosterone	[FSHB protein co-treated with Testosterone] results in increased expression of SGK1 mRNA	18535249
D013739	Testosterone	[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of SGK1 mRNA	18535249
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SGK1 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SGK1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SGK1 mRNA	12377990\|1961957
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SGK1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SGK1 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SGK1 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SGK1 mRNA	18691609
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SGK1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SGK1 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SGK1 mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]	16533503
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]	16533503
D019284	Thapsigargin	Thapsigargin results in decreased expression of SGK1 mRNA	22378314
C009495	titanium dioxide	titanium dioxide results in decreased expression of SGK1 mRNA	21513982
C009495	titanium dioxide	titanium dioxide results in increased expression of SGK1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of SGK1 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SGK1 mRNA	28111298
D014212	Tretinoin	Tretinoin results in decreased expression of SGK1 mRNA	20530235
D014212	Tretinoin	Tretinoin results in increased expression of SGK1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in decreased expression of SGK1 mRNA	16604517
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of SGK1 mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	23946490
C012589	trichostatin A	trichostatin A results in increased expression of SGK1 mRNA	15901671
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SGK1 mRNA"	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SGK1 mRNA"	24407104
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SGK1 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of SGK1 mRNA	29024780
C057693	troglitazone	troglitazone results in increased expression of SGK1 mRNA	28973697
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in decreased expression of SGK1 mRNA	18078969
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGK1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SGK1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of SGK1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of SGK1 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of SGK1 mRNA	17292431
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Dexamethasone results in increased expression of SGK1 mRNA]	23946490
D014635	Valproic Acid	Valproic Acid results in increased expression of SGK1 mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SGK1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of SGK1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of SGK1 mRNA	23034163
D014750	Vincristine	Vincristine results in increased expression of SGK1 mRNA	23649840
D000225	Adenine	Adenine results in decreased expression of SGK1 mRNA	24211769
C111237	vorinostat	[decitabine co-treated with vorinostat] affects the expression of SGK1 mRNA	17330099
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of SGK1 mRNA"	22326570
C009687	wortmannin	wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of SGK1 protein]	21655274

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004712	protein serine/threonine/tyrosine kinase activity	-	IDA	22797923
GO:0005246	calcium channel regulator activity	-	TAS	20530112
GO:0005515	protein binding	-	IPI	15733869 17360471 20237237 27451907
GO:0005524	ATP binding	-	IEA	-
GO:0015459	potassium channel regulator activity	-	IBA	21873635
GO:0015459	potassium channel regulator activity	-	TAS	20530112
GO:0017080	sodium channel regulator activity	-	TAS	20530112
GO:0017081	chloride channel regulator activity	-	TAS	20530112

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	TAS	20919962
GO:0006468	protein phosphorylation	-	TAS	9114008
GO:0006814	sodium ion transport	-	TAS	10884438
GO:0006915	apoptotic process	-	IEA	-
GO:0006974	cellular response to DNA damage stimulus	-	IEA	-
GO:0007616	long-term memory	-	TAS	20530112
GO:0008217	regulation of blood pressure	-	TAS	16460280
GO:0018105	peptidyl-serine phosphorylation	-	IBA	21873635
GO:0030334	regulation of cell migration	-	TAS	20919962
GO:0032411	positive regulation of transporter activity	-	TAS	20530112
GO:0034220	ion transmembrane transport	-	TAS	-
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0042127	regulation of cell proliferation	-	TAS	20530112
GO:0042981	regulation of apoptotic process	-	TAS	20530112
GO:0048812	neuron projection morphogenesis	-	IBA	21873635
GO:0050790	regulation of catalytic activity	-	TAS	20530112
GO:0051090	regulation of DNA-binding transcription factor activity	-	TAS	20530112
GO:0060453	regulation of gastric acid secretion	-	TAS	20530112
GO:0070294	renal sodium ion absorption	-	TAS	16460280

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005739	mitochondrion	-	IEA	-
GO:0005789	endoplasmic reticulum membrane	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IEA	-
GO:0016607	nuclear speck	-	IDA	-

KEGG ID	KEGG Term
hsa04960	Aldosterone-regulated sodium reabsorption

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2672351	Stimuli-sensing channels	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-6804757	Regulation of TP53 Degradation	TAS
R-HSA-6806003	Regulation of TP53 Expression and Degradation	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23991167	Ethanol regulation of serum glucocorticoid kinase 1 expression in DBA2/J mouse prefrontal cortex. (2013)	Costin BN	PLoS One
21430556	Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke. (2011 May)	Dahlberg J	J Hypertens
26903441	High sodium chloride consumption enhances the effects of smoking but does not interact with SGK1 polymorphisms in the development of ACPA-positive status in patients with RA. (2016 May)	Jiang X	Ann Rheum Dis