Gene: CSMD1

64478
PPP1R24
CUB and Sushi multiple domains 1
protein-coding
8p23.2
Ensembl:ENSG00000183117 MIM:608397 Vega:OTTHUMG00000163605 UniprotKB:Q96PZ7
NC_000008.11
PubMed|SNP Mapped
11   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.469e-1 (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13259289chr8:4252510 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3849840chr8:4212973 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11783062chr8:4089803 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2930357chr8:3852138 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs7830364chr8:3824501 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11774223chr8:3809060 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs1383951chr8:3785733 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12678875chr8:3766524 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2589293chr8:3339921 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs596681chr8:3003080 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs596215chr8:3002993 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18317533chr8:4750513CSMD1Gene body2.054e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLGAP20.962
UNC790.961
CACNA1D0.955
CACNA1B0.947
TANC20.947
DRP20.946
LMTK20.937
KALRN0.931
R3HDM10.931
KIAA1549L0.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.583
HEY2-0.58
COPZ2-0.57
ROM1-0.557
YES1-0.552
MYL3-0.548
SNHG18-0.542
RAI14-0.527
VAMP5-0.517
RNF135-0.517

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CSMD1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CSMD1 mRNA]"27071940
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of CSMD1 mRNA"21920950
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CSMD1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CSMD1 mRNA23630614
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CSMD1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CSMD1 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of CSMD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CSMD1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CSMD1 promoter22457795
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CSMD1 mRNA18164116
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CSMD1 mRNA22129741
D000431EthanolEthanol results in decreased expression of CSMD1 mRNA29018328
C039281furanfuran results in increased expression of CSMD1 mRNA25539665
C016517indole-3-carbinolindole-3-carbinol affects the expression of CSMD1 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CSMD1 mRNA22129741
D008694MethamphetamineCSMD1 gene SNP affects the susceptibility to Methamphetamine18316681
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CSMD1 mRNA"20188158
D009532NickelNickel results in decreased expression of CSMD1 mRNA24768652|2558310
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of CSMD1 mRNA19074003
D009966OrphenadrineOrphenadrine affects the expression of CSMD1 mRNA23665939
D017035PravastatinPravastatin results in decreased expression of CSMD1 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of CSMD1 mRNA27225895
D011441PropylthiouracilPropylthiouracil results in increased expression of CSMD1 mRNA24780913
D053260SootSoot results in increased expression of CSMD1 mRNA26551751
C075117squalestatin 1squalestatin 1 affects the expression of CSMD1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of CSMD1 mRNA27225895
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of CSMD1 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSMD1 mRNA21570461

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24876173The clinical and genetic features of COPD-asthma overlap syndrome. (2014 Aug)Hardin MEur Respir J
24986733A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes. (2014 Jul 1)Li MBMC Genet
23541940TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. (2013 May)Yin XYJ Dermatol Sci
24278325Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)Urashima MPLoS One
18316681Genome-wide association for methamphetamine dependence: convergent results from 2 samples. (2008 Mar)Uhl GRArch Gen Psychiatry