Gene: CPEB1

64506
CPE-BP1|CPEB|CPEB-1|h-CPEB|hCPEB-1
cytoplasmic polyadenylation element binding protein 1
protein-coding
15q25.2
Ensembl:ENSG00000214575 MIM:607342 Vega:OTTHUMG00000172877 UniprotKB:Q9BZB8
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.601e-1 (AD)  9.334e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C16orf700.935
HERC10.932
STOX20.921
LMTK20.921
HECTD40.92
SBNO10.92
PRUNE20.916
USP310.916
MTMR40.916
CLCN40.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.519
RAB13-0.519
COPZ2-0.503
GNG11-0.486
MYL3-0.484
MTRNR2L10-0.481
MDFI-0.479
PON3-0.476
ASB4-0.474
HEY2-0.473

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPEB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPEB1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CPEB1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CPEB1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CPEB1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of CPEB1 mRNA20458559
D001280AtrazineAtrazine results in increased expression of CPEB1 mRNA22378314
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CPEB1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPEB1 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of CPEB1 mRNA27685785|2927551
C006780bisphenol Abisphenol A results in decreased expression of CPEB1 mRNA25181051
D002185CannabidiolCannabidiol results in increased expression of CPEB1 mRNA21542829
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CPEB1 mRNA27339419
D004390ChlorpyrifosChlorpyrifos results in increased expression of CPEB1 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPEB1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of CPEB1 mRNA24386269
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CPEB1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of CPEB1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of CPEB1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CPEB1 mRNA19770486
C014347decitabinedecitabine affects the expression of CPEB1 mRNA17145863|2330084
D013759DronabinolDronabinol results in increased expression of CPEB1 mRNA21542829
D002945CisplatinCisplatin affects the expression of CPEB1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of CPEB1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CPEB1 mRNA18042831
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CPEB1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CPEB1 mRNA26033743
C024629dimethyl phthalatedimethyl phthalate affects the expression of CPEB1 mRNA26924002
C118739entinostatentinostat results in increased expression of CPEB1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPEB1 mRNA"27188386
C540355fenamidonefenamidone results in increased expression of CPEB1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPEB1 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of CPEB1 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of CPEB1 mRNA22061828
D008070LipopolysaccharidesCPEB1 affects the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]21620800
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased phosphorylation of CPEB1 protein21620800
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CPEB1 mRNA21620800
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of CPEB1 protein]21620800
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CPEB1 mRNA]21620800
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CPEB1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CPEB1 mRNA28001369
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CPEB1 mRNA26924002
C523799MRK 003CPEB1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CPEB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CPEB1 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in decreased expression of CPEB1 mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of CPEB1 mRNA18042831
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CPEB1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CPEB1 mRNA19482888
D010795Phthalic AcidsPhthalic Acids results in increased expression of CPEB1 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of CPEB1 mRNA23811191
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of CPEB1 protein]21620800
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CPEB1 mRNA]21620800
D012969Sodium FluorideSodium Fluoride results in decreased expression of CPEB1 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CPEB1 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CPEB1 mRNA28111298
C012589trichostatin Atrichostatin A results in increased expression of CPEB1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of CPEB1 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of CPEB1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of CPEB1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CPEB1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of CPEB1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000900translation repressor activity, mRNA regulatory element binding-IBA21873635  
GO:0000900translation repressor activity, mRNA regulatory element binding-ISS-  
GO:0003730mRNA 3'-UTR binding-IBA21873635  
GO:0005515protein binding-IPI28383716  
GO:0008135translation factor activity, RNA binding-IBA21873635  
GO:0035925mRNA 3'-UTR AU-rich region binding-ISS-  
GO:0043022ribosome binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006397mRNA processing-IEA-  
GO:0006412translation-IEA-  
GO:0032869cellular response to insulin stimulus-IDA18752464  
GO:0071230cellular response to amino acid stimulus-ISS-  
GO:0071456cellular response to hypoxia-IDA18752464  
GO:1900365positive regulation of mRNA polyadenylation-IDA28383716  
GO:2000766negative regulation of cytoplasmic translation-IBA21873635  
GO:2000766negative regulation of cytoplasmic translation-IMP18752464  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA28383716  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:1990124messenger ribonucleoprotein complex-IBA21873635  
KEGG ID KEGG Term
hsa04114Oocyte meiosis
hsa04320Dorso-ventral axis formation
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24398667Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers. (2014 Jun)Tessema MCarcinogenesis