Gene: SH3GL3

6457
CNSA3|EEN-B2|HsT19371|SH3D2C|SH3P13
SH3 domain containing GRB2 like 3, endophilin A3
protein-coding
15q25.2
Ensembl:ENSG00000140600 MIM:603362 Vega:OTTHUMG00000147361 UniprotKB:Q99963
NC_000015.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.147e-1 (AD)  8.878e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12905964chr15:83510363 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1491579chr15:83509927 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NKAIN20.883
SYNJ20.865
NIPAL30.862
NIPA10.859
SPOCK30.859
HBS1L0.853
KCNMB40.848
DLG10.845
CCP1100.843
MAP70.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.519
OR4F5-0.449
SYPL2-0.421
MCC-0.382
ARHGAP42-0.378
EVC2-0.377
GJB2-0.366
C4orf19-0.363
KCNK5-0.357
HGF-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SH3GL3 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SH3GL3 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SH3GL3 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SH3GL3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH3GL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH3GL3 mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SH3GL3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SH3GL3 mRNA]17585979
D000638AmiodaroneAmiodarone affects the expression of SH3GL3 mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of SH3GL3 mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SH3GL3 mRNA16483693
C015001arsenitearsenite results in increased expression of SH3GL3 mRNA18929588
D001280AtrazineAtrazine affects the expression of SH3GL3 mRNA25929836
C006780bisphenol Abisphenol A results in increased expression of SH3GL3 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of SH3GL3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SH3GL3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SH3GL3 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of SH3GL3 mRNA26079696
D002104CadmiumCadmium results in decreased expression of SH3GL3 mRNA24376830
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SH3GL3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SH3GL3 mRNA]17585979
D002997ClomipramineClomipramine affects the expression of SH3GL3 mRNA18355885
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SH3GL3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SH3GL3 mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SH3GL3 mRNA25242112
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SH3GL3 mRNA16636312
D002117CalcitriolCalcitriol results in increased expression of SH3GL3 mRNA16002434
C118739entinostatentinostat results in increased expression of SH3GL3 mRNA27188386
D005485FlutamideFlutamide results in increased expression of SH3GL3 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of SH3GL3 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of SH3GL3 mRNA19167457
D017313FenretinideFenretinide results in increased expression of SH3GL3 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of SH3GL3 mRNA26191083
D007099ImipramineImipramine affects the expression of SH3GL3 mRNA18355885
D007654KetoconazoleKetoconazole affects the expression of SH3GL3 mRNA18355885
D007854LeadLead affects the expression of SH3GL3 mRNA28903495
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SH3GL3 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of SH3GL3 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of SH3GL3 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SH3GL3 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of SH3GL3 mRNA23411599
D013893ThiramThiram results in increased expression of SH3GL3 mRNA20530235
D014212TretinoinTretinoin results in increased expression of SH3GL3 mRNA20530235
D014212TretinoinTretinoin results in increased expression of SH3GL3 mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of SH3GL3 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SH3GL3 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH3GL3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SH3GL3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SH3GL3 mRNA23179753|2627250
C025643vinclozolinvinclozolin results in decreased expression of SH3GL3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11894096  15383276  15919751  16115810  16169070  16713569  
17161366  18602463  21900206  24076656  
GO:0008022protein C-terminus binding-IEA-  
GO:0008289lipid binding-IEA-  
GO:0042802identical protein binding-IPI16115810  21900206  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-IEA-  
GO:0007165signal transduction-TAS9169142  
GO:0007417central nervous system development-TAS9169142  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:1900186negative regulation of clathrin-dependent endocytosis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0031901early endosome membrane-IEA-  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseIEA
R-HSA-177929Signaling by EGFRTAS
R-HSA-182971EGFR downregulationTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663205Infectious diseaseIEA
R-HSA-6806834Signaling by METTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cellIEA
R-HSA-8876384Listeria monocytogenes entry into host cellsIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal