Gene: GPR135

64582
HUMNPIIY20
G protein-coupled receptor 135
protein-coding
14q23.1
Ensembl:ENSG00000181619 MIM:607970 Vega:OTTHUMG00000140325 UniprotKB:Q8IZ08
NC_000014.9
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.557e-1 (AD)  8.759e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLUAP10.785
HLTF0.78
TTC80.775
DOCK40.774
DTWD20.771
CCPG10.77
TRAPPC110.769
NDUFS10.765
SLC25A160.765
ACADSB0.764

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.405
CSAG1-0.402
GNG8-0.366
MTRNR2L9-0.361
MTRNR2L6-0.355
SPINK8-0.355
CTNNA3-0.347
TGFB3-0.347
OR4F29-0.346
C7orf61-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GPR135 mRNA"20816883
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GPR135 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPR135 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GPR135 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GPR135 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of GPR135 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GPR135 mRNA28628672
D002509CephaloridineCephaloridine results in decreased expression of GPR135 mRNA18500788
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GPR135 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GPR135 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GPR135 mRNA28628672
D017313FenretinideFenretinide results in increased expression of GPR135 mRNA28973697
D007052IbuprofenIbuprofen results in increased expression of GPR135 mRNA28201806
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GPR135 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GPR135 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GPR135 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GPR135 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GPR135 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GPR135 mRNA28628672
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of GPR135 mRNA19074003
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GPR135 mRNA25895662
D012906SmokeSmoke results in decreased expression of GPR135 mRNA21095227
D053260SootSoot results in increased expression of GPR135 mRNA26551751
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of GPR135 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPR135 mRNA22298810|2257421
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPR135 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPR135 mRNA21570461|2468072
D013849ThimerosalThimerosal results in decreased expression of GPR135 mRNA27188386
C057693troglitazonetroglitazone results in increased expression of GPR135 mRNA28973697
D014520UrethaneUrethane results in decreased expression of GPR135 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of GPR135 gene29154799
C029297vinylidene chloridevinylidene chloride results in decreased expression of GPR135 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of GPR135 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0005515protein binding-IPI28827538  
GO:1990763arrestin family protein binding-IDA28827538  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IDA28827538  
GO:0005886plasma membrane-IDA28827538  
GO:0010008endosome membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26203295Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)Maccani JZAdv Genomics Genet
28722770Asbestos-associated genome-wide DNA methylation changes in lung cancer. (2017 Nov 15)Kettunen EInt J Cancer