Gene: SHBG

6462
ABP|SBP|TEBG
sex hormone binding globulin
protein-coding
17p13.1
Ensembl:ENSG00000129214 MIM:182205 Vega:OTTHUMG00000108153 UniprotKB:P04278
NG_011981.2
PubMed
OD|ND|AD
211   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.283e-2 (AD)  5.269e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC28B0.634
RPP25L0.628
C9orf240.603
COQ10A0.601
TMEM2220.595
JMJD40.591
TEX2640.59
B9D10.59
HDDC30.588
PRADC10.587

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTF-0.409
RNF152-0.352
TRPV5-0.352
VRK2-0.349
DISC1-0.348
VNN2-0.343
CTNNA3-0.342
GJC1-0.342
BAZ1A-0.34
CCL14-0.338

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00179MasoprocolSmall Molecule27686-84-6Approved|InvestigationalTarget
DB00255DiethylstilbestrolSmall Molecule56-53-1Approved|InvestigationalTarget
DB00367LevonorgestrelSmall Molecule797-63-7Approved|InvestigationalTarget
DB00396ProgesteroneSmall Molecule57-83-0ApprovedTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
DB00539ToremifeneSmall Molecule89778-26-7Approved|InvestigationalTarget
DB00655EstroneSmall Molecule53-16-7ApprovedTarget
DB00675TamoxifenSmall Molecule10540-29-1ApprovedTarget
DB00882ClomifeneSmall Molecule911-45-5Approved|InvestigationalTarget
DB00890DienestrolSmall Molecule13029-44-2Approved|InvestigationalTarget
DB00977Ethinyl EstradiolSmall Molecule57-63-6ApprovedTarget
DB01094HesperetinSmall Molecule520-33-2ApprovedTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB01645GenisteinSmall Molecule446-72-0InvestigationalTarget
DB03467NaringeninSmall Molecule480-41-1ExperimentalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB044294'-HydroxyflavanoneSmall MoleculeExperimentalTarget
DB04468AfimoxifeneSmall Molecule68392-35-8InvestigationalTarget
DB04573EstriolSmall Molecule50-27-1Approved|InvestigationalTarget
DB04824PhenolphthaleinSmall Molecule77-09-8Approved|WithdrawnTarget
DB09371NorethynodrelSmall Molecule68-23-5ApprovedTarget
DB11619GestrinoneSmall Molecule16320-04-0ApprovedTarget
DB11674EquolSmall Molecule531-95-3InvestigationalTarget
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalCarrier
DB00648MitotaneSmall Molecule53-19-0ApprovedCarrier
DB00717NorethisteroneSmall Molecule68-22-4ApprovedCarrier
DB00741HydrocortisoneSmall Molecule50-23-7ApprovedCarrier
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalCarrier
DB00858DrostanoloneSmall Molecule58-19-5Approved|IllicitCarrier
DB01185FluoxymesteroneSmall Molecule76-43-7Approved|IllicitCarrier
DB01406DanazolSmall Molecule17230-88-5ApprovedCarrier
DB01420Testosterone propionateSmall Molecule57-85-2Approved|Investigational|WithdrawnCarrier
DB023422-MethoxyestradiolSmall Molecule362-07-2InvestigationalCarrier
DB02901StanoloneSmall Molecule521-18-6Illicit|InvestigationalCarrier
DB038825-Alpha-Androstane-3-Beta,17beta-DiolSmall Molecule571-20-0ExperimentalCarrier
DB039265-Alpha-Androstane-3-Beta,17-Alpha-DiolSmall MoleculeExperimentalCarrier
DB04574Estrone sulfateSmall Molecule481-97-0ApprovedCarrier
DB06412OxymetholoneSmall Molecule434-07-1Approved|IllicitCarrier
DB06710MethyltestosteroneSmall Molecule58-18-4ApprovedCarrier
DB09124MedrogestoneSmall Molecule977-79-7ApprovedCarrier
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedCarrier
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedCarrier
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalCarrier
DB13951Stanolone acetateSmall Molecule1164-91-6ExperimentalCarrier
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalCarrier
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalCarrier
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalCarrier
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalCarrier
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C03570217-desoxyestradiol17-desoxyestradiol binds to SHBG protein25349334
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of SHBG protein"3199457
C1214792,4-dihydroxybenzophenone"2,4-dihydroxybenzophenone binds to SHBG protein"25349334
C0013902-hydroxyestradiol2-hydroxyestradiol results in increased expression of SHBG mRNA21793624
C0013902-hydroxyestradiol2-hydroxyestradiol results in increased expression of SHBG protein21793624
C0339322-sec-butylphenol2-sec-butylphenol binds to SHBG protein25349334
C5438473',4'-dihydroxy-4-monochlorobiphenyl"SHBG protein results in decreased susceptibility to 3',4'-dihydroxy-4-monochlorobiphenyl"19619627
C0020063-deoxyestrone3-deoxyestrone binds to SHBG protein25349334
C4689103-hydroxyflavanone3-hydroxyflavanone binds to SHBG protein25349334
C0101184,4'-dihydroxystilbene"4,4'-dihydroxystilbene binds to SHBG protein"25349334
C5278334-(heptyloxy)phenol4-(heptyloxy)phenol binds to SHBG protein25349334
C4278244-hydroxy-2',3',4'-5'-tetrachlorobiphenyl"4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl binds to SHBG protein"25349334
C4510194-hydroxychalcone4-hydroxychalcone binds to SHBG protein25349334
C5614484'-hydroxychalcone4'-hydroxychalcone binds to SHBG protein25349334
C0140364-hydroxyestradiol4-hydroxyestradiol results in increased expression of SHBG mRNA21793624
C0140364-hydroxyestradiol4-hydroxyestradiol results in increased expression of SHBG protein21793624
C5611234'-hydroxyflavanone4'-hydroxyflavanone binds to SHBG protein25349334
C0415944-nonylphenol4-nonylphenol binds to SHBG protein25349334
C0415944-nonylphenol4-nonylphenol binds to SHBG protein15081833
C0804174-octylphenol4-octylphenol binds to SHBG protein25349334
C0804174-octylphenol4-octylphenol binds to SHBG protein15081833
C1205044-tert-octylcatechol4-tert-octylcatechol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
C1052604-tert-octylphenol4-tert-octylphenol binds to SHBG protein11792437
C1052604-tert-octylphenol4-tert-octylphenol binds to SHBG protein15556074
C1052604-tert-octylphenol4-tert-octylphenol inhibits the reaction [Estradiol binds to SHBG protein]15556074
C0593537-hydroxyflavanone7-hydroxyflavanone binds to SHBG protein25349334
C016601afimoxifeneafimoxifene binds to SHBG protein25349334
C016601afimoxifeneafimoxifene binds to SHBG protein11792437
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SHBG gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SHBG mRNA21632981
D000438AlcoholsAlcohols results in increased expression of SHBG protein8590623
D013196Dihydrotestosterone4-tert-octylcatechol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D013196DihydrotestosteroneCoumestrol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D013196DihydrotestosteroneDihydrotestosterone binds to SHBG protein18725242
D013196DihydrotestosteroneHexestrol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D013196Dihydrotestosteronepodocarpic acid inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D013196DihydrotestosteroneThyronines inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D013196Dihydrotestosteronedelta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneDihydrotestosterone binds to SHBG protein25349334
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of SHBG protein23936228
D013196DihydrotestosteroneLindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196Dihydrotestosteronenonylphenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196Dihydrotestosterone"o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]"9171990
D013196DihydrotestosteronePentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneSHBG affects the reaction [Dihydrotestosterone results in increased expression of CD44 protein]23936228
D013196DihydrotestosteroneSHBG affects the reaction [Dihydrotestosterone results in increased expression of NANOG protein]23936228
D013196DihydrotestosteroneSHBG affects the reaction [Dihydrotestosterone results in increased expression of POU5F1 protein]23936228
D013196DihydrotestosteroneSHBG affects the reaction [Dihydrotestosterone results in increased expression of THY1 protein]23936228
D013196DihydrotestosteroneAtrazine inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneDDT analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneDDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196Dihydrotestosteronedelta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneDichlorodiphenyl Dichloroethylene analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneDieldrin inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneLindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196DihydrotestosteroneMethoxychlor inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D013196Dihydrotestosterone"o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]"9171990
D013196DihydrotestosteronePentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SHBG mRNA16483693
D000728AndrogensSHBG promoter polymorphism affects the abundance of Androgens16926255
D047310ApigeninApigenin binds to SHBG protein25349334
D001280AtrazineAtrazine inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D001280AtrazineAtrazine results in increased expression of SHBG mRNA22372587
D001280AtrazineQuercetin inhibits the reaction [Atrazine results in increased expression of SHBG mRNA]22372587
C017037aurinaurin binds to SHBG protein25349334
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SHBG mRNA21632981
C057775benzylparabenbenzylparaben binds to SHBG protein25349334
D004958EstradiolCopper promotes the reaction [Estradiol results in increased expression of SHBG mRNA]19685012
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of SHBG protein]16551731
D004958EstradiolEstradiol binds to SHBG protein25349334
D004958EstradiolEstradiol promotes the reaction [Copper affects the expression of SHBG mRNA]19685012
D004958EstradiolEstradiol results in increased expression of SHBG mRNA19685012|2163290
D004958EstradiolEstradiol results in increased expression of SHBG protein16551731|1748451
D004958EstradiolEstradiol binds to SHBG protein15081833
D004958Estradiol4-tert-octylphenol inhibits the reaction [Estradiol binds to SHBG protein]15556074
D004958Estradiolbisphenol A inhibits the reaction [Estradiol binds to SHBG protein]15556074
D004958EstradiolDiethylstilbestrol inhibits the reaction [Estradiol binds to SHBG protein]15556074
D004958EstradiolEstradiol binds to SHBG protein15556074
D004958EstradiolEthinyl Estradiol inhibits the reaction [Estradiol binds to SHBG protein]15556074
D004958EstradiolGenistein inhibits the reaction [Estradiol binds to SHBG protein]15556074
D004958EstradiolZearalenone inhibits the reaction [Estradiol binds to SHBG protein]15556074
C006780bisphenol Abisphenol A binds to SHBG protein25349334
C006780bisphenol Abisphenol A binds to SHBG protein11792437
C006780bisphenol Abisphenol A results in increased expression of SHBG mRNA24534842
C006780bisphenol Abisphenol A affects the expression of SHBG mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SHBG mRNA25181051
C006780bisphenol Abisphenol A binds to SHBG protein15556074
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol binds to SHBG protein]15556074
C006780bisphenol Abisphenol A binds to SHBG protein26700111
C492482bisphenol Bbisphenol B binds to SHBG protein25349334
C027561butylbenzyl phthalatebutylbenzyl phthalate binds to SHBG protein25349334
D002104CadmiumCadmium results in increased expression of SHBG protein23193971
D002104Cadmiumpectin inhibits the reaction [Cadmium results in increased expression of SHBG protein]23193971
D002220CarbamazepineCarbamazepine results in increased expression of SHBG protein11148232
D002220CarbamazepineCarbamazepine results in increased expression of SHBG protein16004674
D002569CeruleninCerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]17992261
D002569CeruleninCerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein]17992261
D002599ChalconeChalcone binds to SHBG protein25349334
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of SHBG protein28596144
C043561chrysinchrysin binds to SHBG protein25349334
D002996ClomipheneClomiphene binds to SHBG protein25349334
C018021cobaltous chloridecobaltous chloride results in decreased expression of SHBG mRNA24612858
D003277Contraceptives, Oral, Combined"Contraceptives, Oral, Combined results in increased expression of SHBG protein"16409223
D003300CopperCopper promotes the reaction [Estradiol results in increased expression of SHBG mRNA]19685012
D003300CopperCopper results in decreased expression of SHBG mRNA19685012
D003300CopperEstradiol promotes the reaction [Copper affects the expression of SHBG mRNA]19685012
D003345CorticosteroneCorticosterone binds to SHBG protein25349334
D003375CoumestrolCoumestrol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D003375CoumestrolCoumestrol binds to SHBG protein25349334
D065366CryptoxanthinsCryptoxanthins inhibits the reaction [Lipopolysaccharides results in decreased expression of SHBG mRNA]26686910
D065366CryptoxanthinsCryptoxanthins results in increased expression of SHBG mRNA26686910
D016572CyclosporineCyclosporine results in decreased expression of SHBG mRNA25562108
D003634DDTDDT analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D003634DDTDDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SHBG mRNA23640034
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
C086916delta-hexachlorocyclohexanedelta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D003993Dibutyl PhthalateDibutyl Phthalate binds to SHBG protein25349334
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SHBG protein12408638
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of SHBG mRNA16380112
D004026DieldrinDieldrin inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D004028DienestrolDienestrol binds to SHBG protein25349334
D019422Dietary SucroseDietary Sucrose results in decreased expression of SHBG mRNA17992261
D019422Dietary SucroseDietary Sucrose results in decreased expression of SHBG protein17992261
C007379diethyl phthalatediethyl phthalate binds to SHBG protein25349334
D004054DiethylstilbestrolDiethylstilbestrol binds to SHBG protein25349334
D004054DiethylstilbestrolDiethylstilbestrol binds to SHBG protein11792437
D004054DiethylstilbestrolDiethylstilbestrol binds to SHBG protein15556074
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [Estradiol binds to SHBG protein]15556074
C100172dimethylstilbestroldimethylstilbestrol binds to SHBG protein25349334
C010715di-n-octyl phthalatedi-n-octyl phthalate binds to SHBG protein25349334
C004839dioxybenzonedioxybenzone binds to SHBG protein25349334
C038345droloxifenedroloxifene binds to SHBG protein25349334
C035144drospirenone[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG protein11245553
D004726EndosulfanEndosulfan binds to SHBG protein15081833
D060754EquolEquol binds to SHBG protein25349334
D004964EstriolEstriol binds to SHBG protein25349334
D004970EstroneEstrone binds to SHBG protein25349334
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SHBG mRNA16872691
D004997Ethinyl EstradiolEthinyl Estradiol binds to SHBG protein25349334
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG protein11245553
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SHBG protein10899481
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of SHBG protein12586319|1498137
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of SHBG protein12586319|1698222
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with ST 1435] results in increased expression of SHBG protein17519148
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SHBG protein11907703|1737470
D004997Ethinyl EstradiolEthinyl Estradiol binds to SHBG protein15081833
D004997Ethinyl EstradiolEthinyl Estradiol binds to SHBG protein11792437
D004997Ethinyl EstradiolEthinyl Estradiol binds to SHBG protein12408638
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SHBG protein12408638
D004997Ethinyl EstradiolEthinyl Estradiol binds to SHBG protein15556074
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [Estradiol binds to SHBG protein]15556074
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of SHBG protein14981370
C012313ethyl-p-hydroxybenzoateethyl-p-hydroxybenzoate binds to SHBG protein25349334
D015025ZearalenoneZearalenone binds to SHBG protein11792437
D015025ZearalenoneZearalenone binds to SHBG protein15556074
D015025ZearalenoneZearalenone inhibits the reaction [Estradiol binds to SHBG protein]15556074
C028610flavanoneflavanone binds to SHBG protein25349334
D005632FructoseCerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]17992261
D005632FructoseFructose affects the reaction [NR2F1 protein binds to SHBG promoter]17992261
D005632FructoseFructose results in decreased expression of SHBG protein17992261
D019833GenisteinGenistein binds to SHBG protein25349334
D019833GenisteinGenistein results in increased expression of SHBG mRNA18847459
D019833GenisteinGenistein binds to SHBG protein11792437
D019833GenisteinGenistein binds to SHBG protein15556074
D019833GenisteinGenistein inhibits the reaction [Estradiol binds to SHBG protein]15556074
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SHBG protein10899481
D005947GlucoseCerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein]17992261
D005947GlucoseGlucose affects the reaction [HNF4A protein binds to SHBG promoter]17992261
D005947GlucoseGlucose affects the reaction [NR2F1 protein binds to SHBG promoter]17992261
D005947GlucoseGlucose results in decreased expression of SHBG protein17992261
C010974glyphosateglyphosate results in decreased expression of SHBG mRNA24273285
C013015hesperetinhesperetin binds to SHBG protein25349334
D006589HexestrolHexestrol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
C467540iodobisphenol Aiodobisphenol A binds to SHBG protein11996937
D001556LindaneLindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D001556LindaneLindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D001556LindaneLindane results in decreased expression of SHBG protein18248869
D008044LinuronLinuron results in decreased expression of SHBG mRNA28705778
D008070LipopolysaccharidesCryptoxanthins inhibits the reaction [Lipopolysaccharides results in decreased expression of SHBG mRNA]26686910
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SHBG mRNA26686910
D009637MasoprocolMasoprocol binds to SHBG protein25349334
D008627Mercuric ChlorideMercuric Chloride affects the expression of SHBG mRNA20353558
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of SHBG mRNA12606434|1848617
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of SHBG protein12606434
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of SHBG mRNA12606434
D008731MethoxychlorMethoxychlor inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
C015358methylparabenmethylparaben binds to SHBG protein25349334
C011310moxestrolmoxestrol binds to SHBG protein25349334
C005273naringeninnaringenin binds to SHBG protein25349334
D009532NickelNickel results in increased expression of SHBG mRNA24084258
C022838nickel chloridenickel chloride results in decreased expression of SHBG mRNA24612858
C025256nonylphenolnonylphenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
C025256nonylphenolnonylphenol results in decreased expression of SHBG protein27832966
C025256nonylphenolnonylphenol results in increased expression of SHBG mRNA27832966
C025256nonylphenolwortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA]27832966
D009641NorethynodrelNorethynodrel binds to SHBG protein25349334
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of SHBG protein12586319|1698222
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of SHBG protein12586319|1498137
D016912LevonorgestrelLevonorgestrel binds to SHBG protein12586319
C076029olanzapineolanzapine results in decreased expression of SHBG protein19512971
C016340o,p'-DDT"o,p'-DDT binds to SHBG protein"25349334
C016340o,p'-DDT"o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]"9171990
C016340o,p'-DDT"o,p'-DDT binds to SHBG protein"11792437
C016340o,p'-DDT"o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]"9171990
C511292Ortho EvraOrtho Evra results in increased expression of SHBG protein16982228
D008939MitotaneESR1 protein promotes the reaction [Mitotane results in increased expression of SHBG protein]16551731
D008939MitotaneMitotane binds to SHBG protein25349334
D008939MitotaneMitotane results in increased expression of SHBG protein16551731
D010074OxandroloneOxandrolone results in decreased expression of SHBG protein17961146
C036006oxcarbazepineoxcarbazepine results in increased expression of SHBG protein11148232
D010171Palmitoyl Coenzyme APalmitoyl Coenzyme A results in decreased expression of SHBG mRNA17992261
D010171Palmitoyl Coenzyme APalmitoyl Coenzyme A results in decreased expression of SHBG protein17992261
D052638Particulate MatterParticulate Matter results in decreased expression of SHBG mRNA29165613
C030121pectinpectin inhibits the reaction [Cadmium results in increased expression of SHBG protein]23193971
D010416PentachlorophenolPentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
D010416PentachlorophenolPentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]9171990
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of SHBG mRNA20580666
D020113PhenolphthaleinPhenolphthalein binds to SHBG protein25349334
D010693PhloretinPhloretin binds to SHBG protein25349334
C002470podocarpic acidpodocarpic acid inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D011374ProgesteroneProgesterone binds to SHBG protein25349334
C006068propylparabenpropylparaben binds to SHBG protein25349334
D011441PropylthiouracilPropylthiouracil affects the expression of SHBG mRNA7819453
D011441PropylthiouracilPropylthiouracil results in decreased expression of SHBG mRNA24780913
D011794QuercetinQuercetin binds to SHBG protein25349334
D011794QuercetinQuercetin results in increased expression of SHBG mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Atrazine results in increased expression of SHBG mRNA]22372587
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SHBG protein16775175|1691266
C017947sodium arsenitesodium arsenite results in increased expression of SHBG mRNA17451858
C016104sodium bichromatesodium bichromate results in decreased expression of SHBG mRNA24612858
D012999SomanSoman results in decreased expression of SHBG mRNA19281266
C029167ST 1435[Ethinyl Estradiol co-treated with ST 1435] results in increased expression of SHBG protein17519148
C028226taleranoltaleranol binds to SHBG protein25349334
D013629TamoxifenTamoxifen binds to SHBG protein25349334
D013629TamoxifenTamoxifen results in increased expression of SHBG protein14692654|2033231
D013739TestosteroneTestosterone binds to SHBG protein25349334
D013739TestosteroneTestosterone results in increased expression of SHBG mRNA21632903
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of SHBG mRNA20189893
D013970ThyroninesThyronines inhibits the reaction [Dihydrotestosterone binds to SHBG protein]18725242
D017312ToremifeneToremifene binds to SHBG protein25349334
D017312ToremifeneToremifene results in increased expression of SHBG protein14692654
D014204Trenbolone AcetateTrenbolone Acetate affects the expression of SHBG protein24072461
C013042trestolone acetatetrestolone acetate results in decreased expression of SHBG protein14602755
D014212TretinoinTretinoin results in decreased expression of SHBG mRNA18230668
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SHBG gene27618143
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SHBG mRNA17982090
C037749triphenylethylenetriphenylethylene binds to SHBG protein25349334
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SHBG mRNA"26179874
D014873Water PollutantsWater Pollutants results in increased expression of SHBG mRNA24086568
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of SHBG mRNA"22326570
C009687wortmanninwortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA]27832966
C029659zearalenolzearalenol binds to SHBG protein25349334
D015029ZeranolZeranol binds to SHBG protein25349334
D015032ZincSHBG protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005496steroid binding-IEA-  
GO:0005497androgen binding-TAS2587256  
GO:0005515protein binding-IPI16143106  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17445656Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III). (2007 Apr)Rohrmann SUrology
18262187Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA). (2008 Oct)Michos EDAtherosclerosis
17456570Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. (2007 Jul)Rohrmann SJ Clin Endocrinol Metab
23765753Total testosterone and sex hormone-binding globulin are significantly associated with metabolic syndrome in middle-aged and elderly men. (2013 Jul)Chin KYExp Clin Endocrinol Diabetes
20106959Sex hormone-binding globulin as an independent predictor of incident type 2 diabetes mellitus in men. (2010 May)Lakshman KMJ Gerontol A Biol Sci Med Sci
28704597Are incident gallstones associated to sex-dependent changes with age? A cohort study. (2017 Sep)Shabanzadeh DMAndrology
21733993Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters. (2011 Sep)Grigorova MJ Clin Endocrinol Metab
11352783Effect of cigarette smoking on levels of bioavailable testosterone in healthy men. (2001 Jun)English KMClin Sci (Lond)
21239514SHBG, sex hormones, and inflammatory markers in older women. (2011 Apr)Maggio MJ Clin Endocrinol Metab
15777555Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME study. (2005 Apr)Bataille VAtherosclerosis
25592661Association Between Endogenous Sex Hormones and Liver Fat in a Multiethnic Study of Atherosclerosis. (2015 Sep)Lazo MClin Gastroenterol Hepatol
27462374Obesity, maternal smoking and SHBG in neonates. (2016)Dharashivkar SDiabetol Metab Syndr
8626841Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. (1996 May)Vermeulen AJ Clin Endocrinol Metab
12640346Androgen and SHBG serum concentrations in late post-menopause women. (2003 Mar)Skalba PMed Sci Monit
19512971Hormonal markers of metabolic dysregulation in patients with severe mental disorders after olanzapine treatment under real-life conditions. (2009 Apr)Birkenaes ABJ Clin Psychopharmacol
23602133The relation between sex hormone levels, the androgen receptor CAGn-polymorphism and depression and mortality in older men in a community study. (2013 Oct)Schneider GPsychoneuroendocrinology
1563834Body measurements, estrogen availability and the risk of human breast cancer: a case-control study. (1992 Apr 22)Bruning PFInt J Cancer
17507613Usual physical activity and endogenous sex hormones in postmenopausal women: the European prospective investigation into cancer-norfolk population study. (2007 May)Chan MFCancer Epidemiol Biomarkers Prev
12708727Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women. (2003 Feb)Allen NECancer Causes Control
17287097Testosterone and cognitive function in ageing men: data from the Florey Adelaide Male Ageing Study (FAMAS). (2007 Jun 20)Martin DMMaturitas
16216530Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. (2006 Feb)Joffe HVAnn Epidemiol
16817831Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study. (2006 Jul)Derby CAClin Endocrinol (Oxf)
27163357Sex Steroids, Sex Hormone-Binding Globulin and Cardiovascular Health in Men and Postmenopausal Women: The Rotterdam Study. (2016 Jul)Jaspers LJ Clin Endocrinol Metab
16417414Cross-sectional association between markers of inflammation and serum sex steroid levels in the postmenopausal estrogen/progestin interventions trial. (2006 Jan-Feb)Crandall CJ Womens Health (Larchmt)
2923845Cigarette smoking in pregnancy results in marked decrease in maternal hCG and oestradiol levels. (1989 Jan)Bernstein LBr J Obstet Gynaecol
2115047The relationship of total and free estrogens and sex hormone-binding globulin with lipoproteins in women. (1990 Jul)Longcope CJ Clin Endocrinol Metab
23102785The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older persons. (2012 Dec)Maggio MAtherosclerosis
103717Sex steroids and sex-hormone binding globulin in males with chronic alcoholism. (1978 Oct)Lindholm JEur J Clin Invest
21574855Serum testosterone levels during early pregnancy in patients developing preeclampsia. (2011 Sep)Tuutti EKScand J Clin Lab Invest
26177638Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from a cross-sectional SPECT-China study. (2015 Jul 16)Wang NReprod Biol Endocrinol
7647819Total but not bioavailable testosterone is a predictor of central adiposity in postmenopausal women. (1995 May)Goodman-Gruen DInt J Obes Relat Metab Disord
11431598Erectile dysfunction and lower androgenicity in type 1 diabetic patients. (2001 Jun)Alexopoulou ODiabetes Metab
12074505Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men. (2002 May)Allen NECancer Causes Control
16091487Androgens are associated with hemostatic and inflammatory factors among women at the mid-life. (2005 Nov)Sowers MRJ Clin Endocrinol Metab
15483091Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence. (2005 Jan)Bliesener NJ Clin Endocrinol Metab
20573680High prevalence of polycystic ovary syndrome in women born small for gestational age. (2010 Aug)Melo ASHum Reprod
12521404Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women. (2002 Nov)Oncken CNicotine Tob Res
15794243[Symptoms of andropausal syndrome in smoking and non-smoking males]. (2004)Ludwikowski GPrzegl Lek
22150314Trends in sex hormone concentrations in US males: 1988-1991 to 1999-2004. (2012 Jun)Nyante SJInt J Androl
12110412Relation of sex hormones to bone mineral density in middle-aged men during a 4 year exercise intervention trial. (2002 Jul)Huuskonen JBone
18432124[High risk of atherosclerosis in men aged 20-39 from Lodz agglomeration]. (2007 Dec)Slowikowska-Hilczer JPol Merkur Lekarski
27898110Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study. (2016 Nov 29)Chen CSci Rep
17142943Effect of smoking and smoking cessation on bone mass, bone remodeling, vitamin D, PTH and sex hormones. (2006 Jul-Sep)Supervia AJ Musculoskelet Neuronal Interact
29109457Non-alcoholic fatty liver disease is an influencing factor for the association of SHBG with metabolic syndrome in diabetes patients. (2017 Nov 6)Hua XSci Rep
19579140The relation between urinary incontinence and steroid hormone levels in perimenopausal women. A report from the Women's Health in the Lund Area (WHILA) study. (2009)Teleman PMActa Obstet Gynecol Scand
17132759Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men. (2006 Dec)Nakhai Pour HREur J Endocrinol
9541143Testosterone as a biological marker in psychopathy and alcoholism. (1998 Feb 9)Stalenheim EGPsychiatry Res
26680482The steroid spectrum during and after quitting smoking. (2015)Jandikova HPhysiol Res
3818901Relationships of plasma estradiol, testosterone, and sex hormone-binding globulin with lipoproteins, apolipoproteins, and high density lipoprotein subfractions in men. (1987 Apr)Stefanick MLJ Clin Endocrinol Metab
2149913Effects of desogestrel and gestodene in low-dose oral contraceptive combinations on lipid and lipoprotein status. A randomized prospective study. (1990 May-Jun)Granata AActa Eur Fertil
21711374Sex hormone-binding globulin at the crossroad of body composition, somatotropic axis and insulin/glucose homeostasis in young healthy men. (2012 Jan)Vanbillemont GClin Endocrinol (Oxf)
24457405Cigarette smoking has a positive and independent effect on testosterone levels. (2013 Oct-Dec)Wang WHormones (Athens)
21478893Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms of androgen deficiency. (2011 May)Allan CAAsian J Androl
3675710Serum lipoproteins, sex hormones and sex hormone binding globulin in middle-aged men of different physical fitness and risk of coronary heart disease. (1987 Oct)Hamalainen EAtherosclerosis
20494855Are environmental levels of bisphenol a associated with reproductive function in fertile men? (2010 Sep)Mendiola JEnviron Health Perspect
9762876Predictors of sex hormone levels among the elderly: a study in Greece. (1998 Oct)Hsieh CCJ Clin Epidemiol
21752884Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study. (2011 Sep)Coviello ADJ Clin Endocrinol Metab
21833558Low testosterone bioavailability is related to prostate cancer diagnose in patients submitted to prostate biopsy. (2012 Jun)Garcia-Cruz EWorld J Urol
19238142Serum adiponectin confers little protection against diabetes and hypertension in Turkish men. (2009 Mar)Onat AObesity (Silver Spring)
1417917Androgenic status in cyclic and postmenopausal women: a comparison between smokers and nonsmokers. (1992 Aug)Ruiz EBiochem Int
27732332Testosterone, Dihydrotestosterone, Sex Hormone-Binding Globulin, and Incident Diabetes Among Older Men: The Cardiovascular Health Study. (2017 Jan 1)Joyce KEJ Clin Endocrinol Metab
11937435Is obesity a risk factor for prostate cancer, and does it even matter? A hypothesis and different perspective. (2002 Apr)Moyad MAUrology
2794371Exogenous estrogen effect on lipid/lipoprotein cholesterol in transsexual males. (1989 Jul-Aug)Damewood MDJ Endocrinol Invest
12679432Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. (2003 Apr)Randolph JF JrJ Clin Endocrinol Metab
17612780Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Tromso study. (2007 Aug)Bjornerem ACalcif Tissue Int
23066943Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study. (2012 Oct 16)Goto ACardiovasc Diabetol
17701661The validity of androgen assays. (2007 Sep)Carruthers MAging Male
24408050Sex hormone-binding globulin (SHBG) as an independent determinant of bone mineral density (BMD) among Chinese middle-aged and elderly men. (2014 Nov)Zha XYEndocrine
20959643Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. (2011 Apr)Relwani RReprod Sci
9096996Sex hormone-binding globulin and glucose tolerance in postmenopausal women. The Rancho Bernardo Study. (1997 Apr)Goodman-Gruen DDiabetes Care
22737230Testosterone is associated with erectile dysfunction: a cross-sectional study in Chinese men. (2012)Liao MPLoS One
9656221[Relationship of increased body weight, androgens, insulin and family history of hypertension with blood pressure in premenopausal women]. (1998 May 23)Orozco PMed Clin (Barc)
1719016Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. (1991 Nov)Gray AJ Clin Endocrinol Metab
11591405Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. (2001 Oct)Lucero JFertil Steril
16868152Maternal testosterone levels during pregnancy are associated with offspring size at birth. (2006 Aug)Carlsen SMEur J Endocrinol
15705366Association of body mass index, age, and cigarette smoking with serum testosterone levels in cycling women undergoing in vitro fertilization. (2005 Feb)Barbieri RLFertil Steril
15111517Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. (2004 May)Laaksonen DEDiabetes Care
20443719Hot flushes and biochemical markers for cardiovascular disease: a randomized trial on hormone therapy. (2010 Oct)Tuomikoski PClimacteric
22777612Inhibitors of 5alpha-reductase-related side effects in patients seeking medical care for sexual dysfunction. (2012 Nov)Corona GJ Endocrinol Invest
16390745Relationship between testosterone serum levels and lifestyle in aging men. (2005 Sep-Dec)Ponholzer AAging Male
8003095Adrenal androgens and testosterone as coronary risk factors in the Helsinki Heart Study. (1994 Feb)Hautanen AAtherosclerosis
23218685Total testosterone and sex hormone-binding globulin are associated with metabolic syndrome independent of age and body mass index in Korean men. (2013 Feb)Hong DMaturitas
11991438Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral density in postmenopausal Japanese women. (2002 Mar)Nagata COsteoporos Int
16497451Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women. (2006 Aug 20)Lebrun CEMaturitas
23936766Serum Retinol and Carotenoids in Association with Biomarkers of Insulin Resistance among Premenopausal Women. (2013 Jan 1)Blondin SAISRN Nutr
26488309The Association of Reproductive Hormone Levels and All-Cause, Cancer, and Cardiovascular Disease Mortality in Men. (2015 Dec)Holmboe SAJ Clin Endocrinol Metab
8664173Cigarette smoking is associated with elevated adrenal androgen response to adrenocorticotropin. (1993 Aug)Hautanen AJ Steroid Biochem Mol Biol
24670886Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study. (2014 Jun)Canoy DEur J Endocrinol
12887292The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study. (2003 Aug)Svartberg JEur J Endocrinol
15638872Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachusetts Male Ageing Study. (2005 Jan)Mohr BAClin Endocrinol (Oxf)
18849030Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis. (2009 May)Ouyang PAtherosclerosis
28124112Is there room for behavioral and modifiable health-related targets in the lower urinary tract symptoms' scenario. (2017 Sep)Ikari OWorld J Urol
27711240Reference Ranges and Association of Age and Lifestyle Characteristics with Testosterone, Sex Hormone Binding Globulin, and Luteinizing Hormone among 1166 Western Chinese Men. (2016)Shen XPLoS One
27055508[Correlation of serum sex hormone levels with metabolic syndrome in elderly men]. (2016 Mar 8)Xiao HYZhonghua Yi Xue Za Zhi
28958048Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project. (2018 May 9)Hsu BJ Gerontol A Biol Sci Med Sci
26796865Visceral fat dysfunction is positively associated with hypogonadism in Chinese men. (2016 Jan 22)Wang NSci Rep
25158929Association between circulating levels of sex steroid hormones and Barrett's esophagus in men: a case-control analysis. (2015 Apr)Cook MBClin Gastroenterol Hepatol
6415991Relationship of high density lipoprotein cholesterol with total and free testosterone and sex hormone binding globulin. (1983 Oct)Heller RFActa Endocrinol (Copenh)
22188108Chronic cigarette smoking alters circulating sex hormones and neuroactive steroids in premenopausal women. (2012)Duskova MPhysiol Res
17224854Endogenous androgen levels and cardiovascular risk profile in women across the adult life span. (2007 Jul-Aug)Bell RJMenopause
23775354Longitudinal changes in testosterone over five years in community-dwelling men. (2013 Aug)Shi ZJ Clin Endocrinol Metab
23425925Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. (2013 Mar)Camacho EMEur J Endocrinol
20368409Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. (2010 Jul)Li CDiabetes Care
22420889Relation of total and free testosterone and sex hormone-binding globulin with cardiovascular risk factors in men aged 24-45 years. The Cardiovascular Risk in Young Finns Study. (2012 May)Firtser SAtherosclerosis
22221653Testosterone, SHBG and differential white blood cell count in middle-aged and older men. (2012 Mar)Brand JSMaturitas
10366167Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo Study. (1999 Jun)Barrett-Connor EJ Am Geriatr Soc
21926281Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study. (2011 Nov)Bhasin SDiabetes Care
11474474Cardiovascular risk factors in men: The role of gonadal steroids and sex hormone-binding globulin. (2001 Aug)Gyllenborg JMetabolism
15964254Risk factors for clinical stress fractures in male military recruits: a prospective cohort study. (2005 Aug)Valimaki VVBone
23463406Both total testosterone and sex hormone-binding globulin are independent risk factors for metabolic syndrome: results from Fangchenggang Area Male Health and Examination Survey in China. (2013 Jul)Zhang JDiabetes Metab Res Rev
15021445Androgens, insulin-like growth factor-I (IGF-I), and carrier proteins (SHBG, IGFBP-3) in postmenopause. (2004 Mar-Apr)Gambera AMenopause
18368555Role of hormonal and other factors in human prostate cancer. (2008 Mar)Wigle DTJ Toxicol Environ Health B Crit Rev
8977755Androgens and the menopause; a study of 40-60-year-old women. (1996 Nov)Bancroft JClin Endocrinol (Oxf)
21871671Association between sex hormone levels and leukoaraiosis (LA) in older Korean men. (2012 Mar-Apr)Park BJArch Gerontol Geriatr
21503646Influence of insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 on bone health: results from the European Male Ageing Study. (2011 Jun)Pye SRCalcif Tissue Int
21566412Baseline data from the TRiUS registry: symptoms and comorbidities of testosterone deficiency. (2011 May)Miner MMPostgrad Med
25851658Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome? (2015 Nov-Dec)Yang YHAsian J Androl
22091971Testosterone and sex hormone-binding globulin have significant association with metabolic syndrome in Taiwanese men. (2012 Mar)Liao CHAging Male
19837922Influence of preterm birth and birth size on gonadal function in young men. (2009 Nov)Kerkhof GFJ Clin Endocrinol Metab
19306067Lifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC). (2009 Aug)Suzuki RCancer Causes Control
29290213Sex hormone levels and change in left ventricular structure among men and post-menopausal women: The Multi-Ethnic Study of Atherosclerosis (MESA). (2018 Feb)Subramanya VMaturitas
2015967Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM. 12-yr follow-up of population study of women in Gothenburg, Sweden. (1991 Jan)Lindstedt GDiabetes
9292943Circulating telopeptide type I is a peripheral marker of thyroid hormone action in hyperthyroidism and during levothyroxine suppressive therapy. (1997 Aug)Loviselli AThyroid
12430143Relationship of serum sex-steroid hormones and prostate volume in African American men. (2002 Dec 1)Joseph MAProstate
7548356Body mass and physical activity are important predictors of serum androgen concentrations in young healthy men. (1995 Jul)Mantzoros CSEpidemiology
20670224Ovarian function and cigarette smoking. (2010 Sep)Whitcomb BWPaediatr Perinat Epidemiol
6682470Relationship of plasma HDL-cholesterol to testosterone, estradiol, and sex-hormone-binding globulin levels in men and women. (1983 May)Semmens JMetabolism
17364602Relation of body mass and sex steroid hormone levels to hot flushes in a sample of mid-life women. (2007 Feb)Schilling CClimacteric
19064566Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women. (2008 Dec)Thompson DJCancer Epidemiol Biomarkers Prev
22959460Low concentration of circulating antimullerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study. (2012 Dec)Hagen CPFertil Steril
7962322The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. (1994 Nov)Field AEJ Clin Endocrinol Metab
26991691Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES. (2016 Aug)Anic GMClin Endocrinol (Oxf)
11011124Relations of insulin resistance and serum concentrations of estradiol and sex hormone-binding globulin to potential breast cancer risk factors. (2000 Sep)Nagata CJpn J Cancer Res
17039471Sex hormone-binding globulin and androgen levels in immigrant and British-born premenopausal British Pakistani women: evidence of early life influences? (2006 Nov-Dec)Pollard TMAm J Hum Biol
20410223Low free testosterone predicts frailty in older men: the health in men study. (2010 Jul)Hyde ZJ Clin Endocrinol Metab
25969924Sex-Specific Predictors of Metabolic Syndrome Independent of Its Components. (2015 Aug)Onat AJ Investig Med
26093239Associations of lead and cadmium with sex hormones in adult males. (2015 Oct)Kresovich JKEnviron Res
25961264Cigarette smoking and progesterone and androgen metabolites in premenopausal women. (2011 Jun 1)Duskova MHorm Mol Biol Clin Investig
20012940Gonadal sex steroid status and bone health in middle-aged and elderly European men. (2010 Aug)Vanderschueren DOsteoporos Int
28581026Cross-sectional association between testosterone, sex hormone-binding globulin and metabolic syndrome: The Healthy Twin Study. (2017 Nov)Moon HClin Endocrinol (Oxf)
20164295Endogenous steroids measured by high-specificity liquid chromatography-tandem mass spectrometry and prevalent cardiovascular disease in 70-year-old men and women. (2010 Apr)Naessen TJ Clin Endocrinol Metab
15780533Serum androgen levels and insulin resistance in postmenopausal women: association with hormone therapy, tibolone and raloxifene. (2005 Apr 11)Christodoulakos GMaturitas
1571840Cigarette smoking, steroid hormones, and bone mineral density in young women. (1992 Apr)Daniel MCalcif Tissue Int
16301487Association of sex steroid hormones with brain morphology and cognition in healthy elderly men. (2005 Nov 22)Lessov-Schlaggar CNNeurology
18158570Increase of hypophyseal hormone levels in male head and neck cancer patients. (2007)Remenar EPathol Oncol Res
19277882Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. (2009 Aug)Shiels MSCancer Causes Control
21832108Cigarette smoking and endogenous sex hormones in postmenopausal women. (2011 Oct)Brand JSJ Clin Endocrinol Metab
21424597Association of serum alpha-tocopherol with sex steroid hormones and interactions with smoking: implications for prostate cancer risk. (2011 Jun)Mondul AMCancer Causes Control
1318278Sex hormones and adipose tissue distribution in premenopausal cigarette smokers. (1992 Apr)Daniel MInt J Obes Relat Metab Disord
18274909Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women. (2008 Mar)Chavez-MacGregor MBreast Cancer Res Treat
19473474Evaluation of the effects of cigarette smoking on testosterone levels in adult men. (2009 Jun)Halmenschlager GJ Sex Med
21521259Relation between androgens and cardiovascular risk factors in a young population. (2011 Jun)Gannage-Yared MHClin Endocrinol (Oxf)
24048437Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women. (2014 Jan)Goto AClin Chem
19220545Serum testosterone levels correlate with haemoglobin in middle-aged and older men. (2009 Aug)Yeap BBIntern Med J
23801371Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: etiological factors or risk markers? (2014 Jan 1)Lukanova AInt J Cancer
26434494Blood Cadmium Level Associates with Lower Testosterone and Sex Hormone-Binding Globulin in Chinese men: from SPECT-China Study, 2014. (2016 May)Chen CBiol Trace Elem Res
29393043New determinants for gallstone disease?. (2018 Feb)Shabanzadeh DMDan Med J
2229299Androgens, estrogens, and sex hormone-binding globulin in middle-aged men. (1990 Dec)Longcope CJ Clin Endocrinol Metab
11561184Aging men--challenges ahead. (2001 Sep)Lunenfeld BAsian J Androl
23746309The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study. (2014 Feb)Travison TGClin Endocrinol (Oxf)
22313436Endogenous sex hormones and C-reactive protein in healthy Chinese men. (2013 Jan)Zhang YClin Endocrinol (Oxf)
1460479Determinants of sex hormone levels in men as useful indices in hormone-related disorders. (1992 Dec)Kato IJ Clin Epidemiol
3593486Androgen-oestrogen imbalance in men with chronic alcoholism and fatty liver. (1987)Myking OAlcohol Alcohol
24428256Differential associations of testosterone, dihydrotestosterone and oestradiol with physical, metabolic and health-related factors in community-dwelling men aged 17-97 years from the Busselton Health Survey. (2014 Jul)Yeap BBClin Endocrinol (Oxf)
19351733Lower testosterone levels predict incident stroke and transient ischemic attack in older men. (2009 Jul)Yeap BBJ Clin Endocrinol Metab
24805790Association of serum androgen concentrations with cardiovascular risk factors in elderly male patients with chronic systolic heart failure in China. (2014 Sep)Chen QAging Male
17383645Do sex hormones influence features of the metabolic syndrome in middle-aged women? A population-based study of Swedish women: the Women's Health in the Lund Area (WHILA) Study. (2007 Jul)Shakir YAFertil Steril
21998597Genetic determinants of serum testosterone concentrations in men. (2011 Oct)Ohlsson CPLoS Genet
18364385Correlations between serum testosterone, estradiol, and sex hormone-binding globulin and bone mineral density in a diverse sample of men. (2008 Jun)Araujo ABJ Clin Endocrinol Metab
8604602Does hyperandrogenism explain lower in vitro fertilization (IVF) success rates in smokers? (1996 Feb)Gustafson OActa Obstet Gynecol Scand
24395140Association between endogenous sex steroid hormones and insulin-like growth factor proteins in US men. (2014 Mar)Papatheodorou SICancer Causes Control
12975257Sex hormone levels and risk of cardiovascular events in postmenopausal women. (2003 Oct 7)Rexrode KMCirculation
15687322Endogenous sex hormones and metabolic syndrome in aging men. (2005 May)Muller MJ Clin Endocrinol Metab
24672276Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. (2013 Sep)Al Hayek AAJ Family Community Med
4040371Serum high density lipoprotein subclasses, testosterone and sex-hormone-binding globulin in Trinidadian men of African and Indian descent. (1985 Jun)Miller GJAtherosclerosis
17884445Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women. (2007 Oct)Onat AMetabolism
22879633Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program. (2012 Nov)Kim CJ Clin Endocrinol Metab
15124763Risk of bone loss in men with multiple sclerosis. (2004 Apr)Weinstock-Guttman BMult Scler
10443228[Hormonal metabolic status in breast cancer patients after conservative surgery: comparison with known prognostic criteria]. (1999)Tsyrlina EVVopr Onkol
17712478Interactions among age, adiposity, bodyweight, lifestyle factors and sex steroid hormones in healthy Singaporean Chinese men. (2007 Sep)Goh VHAsian J Androl
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