Gene: EBF2

64641
COE2|EBF-2|O/E-3|OE-3
early B cell factor 2
protein-coding
8p21.2
Ensembl:ENSG00000221818 MIM:609934 Vega:OTTHUMG00000163838 UniprotKB:Q9HAK2
NG_030344.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.129e-1 (AD)  4.557e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11984569chr8:25977452 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LHX80.856
DGKK0.843
ISL10.842
DDC0.839
SLC18A30.837
SLC5A70.829
GPR10.816
GPR1010.798
SLITRK60.793
AMBN0.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH3-0.496
SOHLH1-0.468
SLC17A7-0.438
NTNG2-0.411
NEUROD2-0.4
EMX1-0.366
GALNT9-0.36
YBX2-0.348
TNNT2-0.346
PKDCC-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF2 mRNA"25510870
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of EBF2 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of EBF2 mRNA23626723
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EBF2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to EBF2 promoter]19654925
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EBF2 gene20938992
C118739entinostatentinostat results in decreased expression of EBF2 mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EBF2 gene20938992
D017313FenretinideFenretinide results in decreased expression of EBF2 mRNA28973697
D007854LeadLead affects the expression of EBF2 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of EBF2 mRNA12057914
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EBF2 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EBF2 mRNA26011545
D009532NickelNickel results in decreased expression of EBF2 mRNA25583101
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF2 mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of EBF2 mRNA23557933
C009495titanium dioxidetitanium dioxide results in decreased expression of EBF2 mRNA23557971
C012589trichostatin Atrichostatin A results in decreased expression of EBF2 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of EBF2 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of EBF2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EBF2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of EBF2 mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of EBF2 mRNA17292431|1796380
D001335Vehicle EmissionsVehicle Emissions affects the expression of EBF2 mRNA23940539
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EBF2 gene25560391
C111237vorinostatvorinostat results in decreased expression of EBF2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001709cell fate determination-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0035563positive regulation of chromatin binding-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0050873brown fat cell differentiation-IEA-  
GO:0060612adipose tissue development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet