Gene: ANAPC1

64682
APC1|MCPR|TSG24
anaphase promoting complex subunit 1
protein-coding
2q13
Ensembl:ENSG00000153107 MIM:608473 Vega:OTTHUMG00000131277 UniprotKB:Q9H1A4
NC_000002.12
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.145e-2 (AD)  2.610e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3814026chr2:111884089 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs9653414chr2:111877160 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs10197222chr2:111869646 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs6742515chr2:111867998 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEATR5B0.954
ARFGEF20.95
AVL90.947
DNAJC270.946
RNMT0.945
MYCBP20.944
ARFGEF10.943
CEP680.942
TOPBP10.941
AKT30.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.473
CSAG1-0.473
RAB13-0.465
MYL3-0.439
AQP5-0.433
COPZ2-0.432
ROM1-0.43
HEY2-0.43
RNF135-0.418
FLT3LG-0.416

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ANAPC1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANAPC1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANAPC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANAPC1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ANAPC1 mRNA17562736
D001280AtrazineAtrazine results in increased expression of ANAPC1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANAPC1 mRNA20064835
D004958EstradiolEstradiol results in increased expression of ANAPC1 mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of ANAPC1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of ANAPC1 mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of ANAPC1 mRNA19371625
C006780bisphenol Abisphenol A affects the expression of ANAPC1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of ANAPC1 mRNA28628672
C013418bromfenacoumbromfenacoum results in decreased expression of ANAPC1 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of ANAPC1 mRNA26079696
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ANAPC1 mRNA24763279
D002994ClofibrateClofibrate results in increased expression of ANAPC1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of ANAPC1 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ANAPC1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of ANAPC1 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of ANAPC1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ANAPC1 mRNA21266533
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ANAPC1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANAPC1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANAPC1 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ANAPC1 mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of ANAPC1 mRNA19371625
D005485FlutamideFlutamide results in increased expression of ANAPC1 mRNA24136188
C056507gemcitabinegemcitabine results in increased expression of ANAPC1 mRNA17039268
D019833GenisteinGenistein results in increased expression of ANAPC1 mRNA19371625
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ANAPC1 mRNA24763279
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of ANAPC1 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of ANAPC1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ANAPC1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of ANAPC1 mRNA28628672
D007649KetamineKetamine results in increased expression of ANAPC1 mRNA20080153
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ANAPC1 mRNA21641980
D008727MethotrexateMethotrexate affects the expression of ANAPC1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ANAPC1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ANAPC1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ANAPC1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ANAPC1 mRNA"20188158
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ANAPC1 mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in increased expression of ANAPC1 mRNA"19371625
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ANAPC1 mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of ANAPC1 mRNA24769257
D010416PentachlorophenolPentachlorophenol results in increased expression of ANAPC1 mRNA23892564
C046012pentanalpentanal results in decreased expression of ANAPC1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANAPC1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ANAPC1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of ANAPC1 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of ANAPC1 mRNA]21318169
D010936Plant ExtractsPlant Extracts results in increased expression of ANAPC1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ANAPC1 mRNA22714537
D011748PyrogallolPyrogallol results in increased expression of ANAPC1 mRNA20362636
C059514resveratrolresveratrol results in increased expression of ANAPC1 mRNA25905778
D012402RotenoneRotenone results in decreased expression of ANAPC1 mRNA27979718
C410733scriptaidscriptaid affects the expression of ANAPC1 mRNA18813790
C017947sodium arsenitesodium arsenite results in decreased expression of ANAPC1 mRNA16014739
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ANAPC1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANAPC1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANAPC1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ANAPC1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ANAPC1 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ANAPC1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of ANAPC1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of ANAPC1 mRNA25192806
D014635Valproic AcidValproic Acid affects the expression of ANAPC1 mRNA17292431
C025643vinclozolinvinclozolin results in increased expression of ANAPC1 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of ANAPC1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0061630ubiquitin protein ligase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0007091metaphase/anaphase transition of mitotic cell cycle-IBA21873635  
GO:0031145anaphase-promoting complex-dependent catabolic process-IBA21873635  
GO:0031145anaphase-promoting complex-dependent catabolic process-TAS-  
GO:0051301cell division-IEA-  
GO:0070979protein K11-linked ubiquitination-IBA21873635  
GO:0070979protein K11-linked ubiquitination-IDA18485873  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005680anaphase-promoting complex-IBA21873635  
GO:0005680anaphase-promoting complex-IDA16364912  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04120Ubiquitin mediated proteolysis
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-141405Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsTAS
R-HSA-141430Inactivation of APC/C via direct inhibition of the APC/C complexTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BTAS
R-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/CTAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176407Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseTAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176412Phosphorylation of the APC/CTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179409APC-Cdc20 mediated degradation of Nek2ATAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (2012 Aug 1)Wang KSDrug Alcohol Depend