Gene: SHH

6469
HHG1|HLP3|HPE3|MCOPCB5|SMMCI|ShhNC|TPT|TPTPS
sonic hedgehog
protein-coding
7q36.3
Ensembl:ENSG00000164690 MIM:600725 Vega:OTTHUMG00000151349 UniprotKB:Q15465
NG_007504.2
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.361e-1 (AD)  7.195e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACHE0.788
KCNH20.775
LRRTM10.764
MARCH110.764
RUSC10.754
RCOR20.754
PRRT40.745
ZNF2390.743
ZNRF10.741
SEZ6L20.74

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3B-0.518
MBNL3-0.488
COPZ2-0.485
PARP4-0.483
ARHGAP19-0.48
SEPT10-0.475
REST-0.473
MYOM1-0.471
ALAS2-0.471
MYL3-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0020104-(2-aminoethyl)benzenesulfonylfluoride4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
D000082AcetaminophenAcetaminophen results in decreased expression of SHH mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of SHH mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SHH mRNA16483693
D003913DextroamphetamineSHH protein modified form affects the susceptibility to [Dextroamphetamine co-treated with Oxidopamine]11771942
D000935Antifungal AgentsAntifungal Agents results in decreased expression of SHH mRNA21254369
D001058ApomorphineSHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine]11771942
C006632arsenic trioxidearsenic trioxide inhibits the reaction [SHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]23861973
C006632arsenic trioxidearsenic trioxide results in decreased activity of SHH protein23861973
D001280AtrazineAtrazine results in decreased expression of SHH mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SHH mRNA22610609
D004958Estradiol4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA20660070
D004958EstradiolEstradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D004958EstradiolN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
D004958EstradiolU 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
D004958EstradiolEstradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D004958EstradiolEstradiol results in decreased expression of SHH mRNA15328011
D001623Betamethasone"Betamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SHH mRNA]"22693607
C095105bexarotenebexarotene results in increased expression of SHH mRNA26096596
C006780bisphenol Abisphenol A results in decreased expression of SHH mRNA17515113
C006780bisphenol Abisphenol A results in decreased expression of SHH mRNA25181051
C028031cadmium acetatecadmium acetate results in decreased expression of SHH mRNA23124188
C028031cadmium acetatecadmium acetate results in decreased expression of SHH protein23124188
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of SHH protein19818801
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SHH17707671
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SHH promoter22457795
C084597chlorcyclizinechlorcyclizine results in decreased expression of SHH mRNA21058326
D002737ChloropreneChloroprene results in increased expression of SHH mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of SHH protein28596144
C007095cobaltiprotoporphyrincobaltiprotoporphyrin affects the expression of SHH protein23497794
D005576ColforsinColforsin results in decreased activity of SHH protein12727446
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]27481074
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20395211|2043453
C000541cyclopaminecyclopamine results in decreased expression of SHH mRNA20865013
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]21110116
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]21110116
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]21110116
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 protein]21110116
C000541cyclopaminecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH mRNA]24388991
C000541cyclopaminecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH protein]24388991
C000541cyclopaminecyclopamine inhibits the reaction [SHH protein results in increased expression of SMO mRNA]22552772
C000541cyclopaminecyclopamine results in decreased activity of SHH protein15042696
D003609DactinomycinDactinomycin inhibits the reaction [SHH protein alternative form results in increased expression of ABCG2 protein]21625222
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SHH mRNA19464577|2202756
D002945Cisplatinarsenic trioxide inhibits the reaction [SHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]23861973
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SHH mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SHH mRNA27392435
D002945CisplatinSHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]23861973
D004221DisulfiramDisulfiram results in decreased expression of SHH mRNA8805369
D004221DisulfiramTretinoin inhibits the reaction [Disulfiram results in decreased expression of SHH mRNA]8805369
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of SHH mRNA25198161
D000431EthanolEthanol results in decreased expression of SHH mRNA15108242|1767660
D005031EthylenethioureaEthylenethiourea results in decreased expression of SHH mRNA16369776|1716120
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SHH enhancer17049204
D005419FlavonoidsFlavonoids results in increased expression of SHH mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of SHH mRNA18776995
D005472FluorouracilFluorouracil results in increased expression of SHH mRNA26272751
D005492Folic AcidFolic Acid results in decreased expression of SHH mRNA25006883
C056507gemcitabinegemcitabine results in decreased expression of SHH mRNA20103597
D019833GenisteinGenistein inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20395211
D005947GlucoseGlucose results in decreased expression of SHH24882757
D005947Glucosecyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]27481074
D005947GlucoseSHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]27481074
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein27481074
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SHH mRNA27481074
D005947Glucosepolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein]27481074
D005947GlucoseSHH protein affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]27481074
D005947GlucoseSHH protein affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein]27481074
C010974glyphosateglyphosate results in decreased expression of SHH mRNA20695457
C538724HhAntag691GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]27585885
C538724HhAntag691HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]27585885
C538724HhAntag691HhAntag691 results in decreased expression of SHH mRNA27585885
D017313FenretinideFenretinide results in increased expression of SHH mRNA28973697
C082359imidaclopridimidacloprid results in decreased expression of SHH mRNA27444676
C018986ipriflavoneipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
C018986ipriflavoneipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SHH mRNA27392435
D064747LansoprazoleLansoprazole results in decreased expression of SHH mRNA20437101
C045463leflunomideleflunomide results in increased expression of SHH mRNA19751817
C482199lipopolysaccharide, E coli O55-B5"Betamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SHH mRNA]"22693607
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SHH mRNA"22693607
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SHH mRNA12057914
D008070Lipopolysaccharidescyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]21110116
D008070Lipopolysaccharidescyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]21110116
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SHH mRNA21110116
D008070LipopolysaccharidesSHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]21110116
D008070LipopolysaccharidesSHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]21110116
D008070LipopolysaccharidesSHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 protein]21110116
D018021Lithium ChlorideLithium Chloride results in decreased expression of SHH mRNA26272751
D008555MelittenMelitten results in decreased expression of SHH protein26189965
D008713MethimazoleMethimazole results in increased expression of SHH mRNA25539664
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SHH mRNA21385734
D009151Mustard GasMustard Gas results in decreased expression of SHH mRNA15674843
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of SHH mRNA"25487280
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SHH mRNA"21624382
C007350nitrofennitrofen affects the expression of SHH mRNA12547712
C025589ochratoxin ASHH protein inhibits the reaction [ochratoxin A affects the expression of SOX10 mRNA]24792326
C025589ochratoxin ASHH protein inhibits the reaction [ochratoxin A results in decreased expression of CSPG4 mRNA]24792326
C025589ochratoxin ASHH protein inhibits the reaction [ochratoxin A results in decreased expression of GFAP mRNA]24792326
C025589ochratoxin ASHH protein inhibits the reaction [ochratoxin A results in decreased expression of MOG mRNA]24792326
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of ASCL1 mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of CCND2 mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of DCX mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of DLL3 mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of GLI1 mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of HES5 mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of MKI67 mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of NES mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of PDGFRA mRNA]21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of SOX2 mRNA]21703336
D016627OxidopamineSHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine]11771942
D016627OxidopamineSHH protein modified form affects the susceptibility to [Dextroamphetamine co-treated with Oxidopamine]11771942
D010100Oxygencyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]27481074
D010100OxygenSHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]27481074
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein27481074
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SHH mRNA27481074
D010100Oxygenpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein]27481074
D010100OxygenSHH protein affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]27481074
D010100OxygenSHH protein affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein]27481074
D010400Penicillin GPenicillin G results in increased expression of SHH mRNA26272751
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SHH mRNA25868421
D010672PhenytoinPhenytoin results in increased expression of SHH mRNA26272751
D010882Piperonyl ButoxidePiperonyl Butoxide inhibits the reaction [SHH protein results in increased expression of SMO mRNA]22552772
C006253pirinixic acidpirinixic acid results in decreased expression of SHH mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of SHH mRNA23557933
C058229polydatinpolydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein]27481074
D011374Progesterone4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA20660070
D011374ProgesteroneN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
D011374ProgesteroneProgesterone results in decreased expression of SHH mRNA20660070
D011374ProgesteroneU 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
C059514resveratrolresveratrol results in decreased expression of SHH mRNA23224687
D015474IsotretinoinIsotretinoin results in increased expression of SHH mRNA26096596
D012439SaccharinSaccharin results in decreased expression of SHH mRNA26272751
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SHH mRNA25895662
D012834SilverSilver results in increased expression of SHH mRNA27131904
C017947sodium arsenitesodium arsenite results in increased activity of SHH protein20179202
C017947sodium arsenitesodium arsenite affects the expression of SHH mRNA20056578
C017947sodium arsenitesodium arsenite affects the methylation of SHH gene28589171
C017947sodium arseniteSHH protein results in decreased susceptibility to sodium arsenite25448440
C017947sodium arsenitesodium arsenite results in decreased expression of SHH mRNA25448440
C017947sodium arsenitesodium arsenite results in increased activity of SHH protein20179202
D012969Sodium Fluoridecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH mRNA]24388991
D012969Sodium Fluoridecyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH protein]24388991
D012969Sodium FluorideSodium Fluoride results in increased expression of SHH mRNA24388991
D012969Sodium FluorideSodium Fluoride results in increased expression of SHH protein24388991
D053260SootSoot results in increased expression of SHH mRNA23634900
D013739TestosteroneTestosterone affects the expression of SHH mRNA19929920
D013739TestosteroneTestosterone affects the expression of SHH protein19929920
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with SHH protein] results in increased expression of CDKN1B protein20486776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [SHH protein results in increased expression of CCND1 protein]20486776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased activity of SHH protein20486776
D013893ThiramThiram results in increased expression of SHH mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of SHH mRNA23557971
C479163tofacitinibtofacitinib results in increased expression of SHH mRNA25487280
D014047TolnaftateTolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D014047TolnaftateTolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]20434536
D014118Toxins, Biological"Toxins, Biological affects the expression of SHH mRNA"19682533
D014212TretinoinMIR196A-1 protein inhibits the reaction [Tretinoin results in increased expression of SHH mRNA]16319892
D014212TretinoinTretinoin inhibits the reaction [Disulfiram results in decreased expression of SHH mRNA]8805369
D014212TretinoinTretinoin results in decreased expression of SHH mRNA9224671
D014212TretinoinTretinoin results in increased expression of SHH mRNA16319892|8805369
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GFRA1 mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GLI1 mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFL protein17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFM protein17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NR4A2 mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK1 mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK2 mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK3 mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of PTCH1 mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of RBFOX3 protein17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of SYP protein17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH protein17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein] results in increased expression of MNX1 mRNA17109623
D014212Tretinoin[Tretinoin co-treated with SHH protein] results in increased expression of MNX1 protein17109623
D014212TretinoinSHH protein inhibits the reaction [Tretinoin results in increased expression of PAX7 protein]15996115
D014212TretinoinSHH protein promotes the reaction [Tretinoin results in increased expression of BMP7 mRNA]15996115
D014212Tretinoin[Tretinoin binds to and results in increased activity of RARB protein] which results in increased expression of and results in increased activity of SHH protein16860305
D014212Tretinoin[Tretinoin co-treated with SHH protein] results in increased expression of NKX2-2 protein15996115
D014212Tretinoin[Tretinoin co-treated with SHH protein] results in increased expression of OLIG2 protein15996115
D014212TretinoinTretinoin results in increased expression of SHH mRNA26272751
C032910triadimefontriadimefon results in decreased expression of SHH mRNA21254369
C009524tributyl phosphatetributyl phosphate results in increased expression of SHH mRNA27146889
C012589trichostatin Atrichostatin A results in decreased expression of SHH mRNA15901671
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of SHH mRNA27146889
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of SHH mRNA27146889
C113580U 0126U 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]20660070
C113580U 0126U 0126 results in decreased expression of SHH mRNA20660070
C419664udenafiludenafil results in increased expression of SHH21366883
D014520UrethaneUrethane results in decreased expression of SHH mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of SHH gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SHH mRNA26272751
D014635Valproic AcidValproic Acid results in decreased expression of SHH mRNA15901671
D014640VancomycinVancomycin results in increased expression of SHH mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SHH gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SHH mRNA26682919
D014801Vitamin A[Vitamin A co-treated with INHBA protein] results in decreased expression of SHH mRNA17244017
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of SHH mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005113patched binding-IDA8906787  
GO:0005509calcium ion binding-IDA19561609  
GO:0005515protein binding-IPI19561609  
GO:0005539glycosaminoglycan binding-IEA-  
GO:0008233peptidase activity-IEA-  
GO:0008270zinc ion binding-IDA19561609  
GO:0016015morphogen activity-NAS8647801  
GO:0016015morphogen activity-TAS24431302  
GO:0043237laminin-1 binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001569branching involved in blood vessel morphogenesis-ISS-  
GO:0001570vasculogenesis-ISS-  
GO:0001656metanephros development-ISS-  
GO:0001658branching involved in ureteric bud morphogenesis-ISS-  
GO:0001708cell fate specification-ISS-  
GO:0001755neural crest cell migration-ISS-  
GO:0001947heart looping-ISS-  
GO:0002052positive regulation of neuroblast proliferation-IEA-  
GO:0002076osteoblast development-IEA-  
GO:0002320lymphoid progenitor cell differentiation-IMP14764698  
GO:0003140determination of left/right asymmetry in lateral mesoderm-ISS-  
GO:0006897endocytosis-IEA-  
GO:0007224smoothened signaling pathway-IEP17850284  
GO:0007224smoothened signaling pathway-ISS-  
GO:0007228positive regulation of hh target transcription factor activity-ISS-  
GO:0007267cell-cell signaling-ISS-  
GO:0007389pattern specification process-ISS-  
GO:0007398ectoderm development-IEA-  
GO:0007405neuroblast proliferation-ISS-  
GO:0007411axon guidance-ISS-  
GO:0007417central nervous system development-ISS-  
GO:0007418ventral midline development-TAS11001584  
GO:0007442hindgut morphogenesis-IEA-  
GO:0007507heart development-ISS-  
GO:0007596blood coagulation-IEA-  
GO:0008209androgen metabolic process-ISS-  
GO:0008284positive regulation of cell proliferation-IDA11331587  
GO:0008284positive regulation of cell proliferation-ISS-  
GO:0009880embryonic pattern specification-TAS11001584  
GO:0009949polarity specification of anterior/posterior axis-ISS-  
GO:0009953dorsal/ventral pattern formation-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014003oligodendrocyte development-IEA-  
GO:0014706striated muscle tissue development-IEA-  
GO:0014858positive regulation of skeletal muscle cell proliferation-IEA-  
GO:0014902myotube differentiation-IEA-  
GO:0016539intein-mediated protein splicing-IEA-  
GO:0021513spinal cord dorsal/ventral patterning-IEA-  
GO:0021522spinal cord motor neuron differentiation-IEA-  
GO:0021794thalamus development-IEA-  
GO:0021904dorsal/ventral neural tube patterning-IEA-  
GO:0021930cerebellar granule cell precursor proliferation-ISS-  
GO:0021938smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation-IEA-  
GO:0021978telencephalon regionalization-IEA-  
GO:0030010establishment of cell polarity-IEA-  
GO:0030162regulation of proteolysis-ISS-  
GO:0030177positive regulation of Wnt signaling pathway-IEA-  
GO:0030324lung development-ISS-  
GO:0030326embryonic limb morphogenesis-ISS-  
GO:0030336negative regulation of cell migration-ISS-  
GO:0030539male genitalia development-ISS-  
GO:0030850prostate gland development-ISS-  
GO:0030878thyroid gland development-IEA-  
GO:0030900forebrain development-ISS-  
GO:0030901midbrain development-ISS-  
GO:0030902hindbrain development-ISS-  
GO:0031016pancreas development-IEA-  
GO:0031069hair follicle morphogenesis-IEA-  
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process-IEA-  
GO:0033077T cell differentiation in thymus-ISS-  
GO:0033089positive regulation of T cell differentiation in thymus-ISS-  
GO:0033092positive regulation of immature T cell proliferation in thymus-ISS-  
GO:0034244negative regulation of transcription elongation from RNA polymerase II promoter-IEA-  
GO:0034504protein localization to nucleus-IEA-  
GO:0035115embryonic forelimb morphogenesis-IEA-  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0042127regulation of cell proliferation-ISS-  
GO:0042130negative regulation of T cell proliferation-IEA-  
GO:0042307positive regulation of protein import into nucleus-IEA-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0042481regulation of odontogenesis-ISS-  
GO:0042733embryonic digit morphogenesis-ISS-  
GO:0043010camera-type eye development-IEA-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043369CD4-positive or CD8-positive, alpha-beta T cell lineage commitment-IDA17227833  
GO:0045059positive thymic T cell selection-ISS-  
GO:0045060negative thymic T cell selection-ISS-  
GO:0045109intermediate filament organization-IEA-  
GO:0045445myoblast differentiation-IEA-  
GO:0045596negative regulation of cell differentiation-ISS-  
GO:0045880positive regulation of smoothened signaling pathway-IDA19561609  
GO:0045880positive regulation of smoothened signaling pathway-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA10654605  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046638positive regulation of alpha-beta T cell differentiation-ISS-  
GO:0046639negative regulation of alpha-beta T cell differentiation-IEA-  
GO:0048468cell development-ISS-  
GO:0048538thymus development-ISS-  
GO:0048557embryonic digestive tract morphogenesis-IEA-  
GO:0048617embryonic foregut morphogenesis-IEA-  
GO:0048643positive regulation of skeletal muscle tissue development-IEA-  
GO:0048645animal organ formation-IEA-  
GO:0048663neuron fate commitment-ISS-  
GO:0048706embryonic skeletal system development-IEA-  
GO:0048714positive regulation of oligodendrocyte differentiation-IEA-  
GO:0048754branching morphogenesis of an epithelial tube-ISS-  
GO:0048839inner ear development-IEA-  
GO:0048859formation of anatomical boundary-IEA-  
GO:0048864stem cell development-ISS-  
GO:0051155positive regulation of striated muscle cell differentiation-IEA-  
GO:0051781positive regulation of cell division-IDA11331587  
GO:0060020Bergmann glial cell differentiation-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0060174limb bud formation-IEA-  
GO:0060428lung epithelium development-IEA-  
GO:0060439trachea morphogenesis-IEA-  
GO:0060445branching involved in salivary gland morphogenesis-IEA-  
GO:0060447bud outgrowth involved in lung branching-IEA-  
GO:0060458right lung development-IEA-  
GO:0060459left lung development-IEA-  
GO:0060463lung lobe morphogenesis-IEA-  
GO:0060484lung-associated mesenchyme development-IEA-  
GO:0060516primary prostatic bud elongation-IEA-  
GO:0060523prostate epithelial cord elongation-IEA-  
GO:0060662salivary gland cavitation-IEA-  
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesis-IEA-  
GO:0060685regulation of prostatic bud formation-IEA-  
GO:0060738epithelial-mesenchymal signaling involved in prostate gland development-IDA12221011  
GO:0060769positive regulation of epithelial cell proliferation involved in prostate gland development-IEA-  
GO:0060782regulation of mesenchymal cell proliferation involved in prostate gland development-IEA-  
GO:0060783mesenchymal smoothened signaling pathway involved in prostate gland development-IEA-  
GO:0060840artery development-IEA-  
GO:0060916mesenchymal cell proliferation involved in lung development-IEA-  
GO:0061053somite development-ISS-  
GO:0061189positive regulation of sclerotome development-IDA10654605  
GO:0071285cellular response to lithium ion-IEA-  
GO:0071542dopaminergic neuron differentiation-TAS24431302  
GO:0072001renal system development-IEP17850284  
GO:0072136metanephric mesenchymal cell proliferation involved in metanephros development-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IEA-  
GO:0090370negative regulation of cholesterol efflux-ISS-  
GO:0097190apoptotic signaling pathway-ISS-  
GO:1900175regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry-NAS17507406  
GO:1900180regulation of protein localization to nucleus-IDA11331587  
GO:1904339negative regulation of dopaminergic neuron differentiation-IEA-  
GO:1905327tracheoesophageal septum formation-IEA-  
GO:2000062negative regulation of ureter smooth muscle cell differentiation-ISS-  
GO:2000063positive regulation of ureter smooth muscle cell differentiation-ISS-  
GO:2000357negative regulation of kidney smooth muscle cell differentiation-ISS-  
GO:2000358positive regulation of kidney smooth muscle cell differentiation-ISS-  
GO:2000729positive regulation of mesenchymal cell proliferation involved in ureter development-ISS-  
GO:2001054negative regulation of mesenchymal cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA19561609  
GO:0005615extracellular space-ISS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-ISS-  
GO:0045121membrane raft-ISS-  
KEGG ID KEGG Term
hsa04340Hedgehog signaling pathway
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-373080Class B/2 (Secretin family receptors)IEA
R-HSA-500792GPCR ligand bindingIEA
R-HSA-5358346Hedgehog ligand biogenesisIEA
R-HSA-5358346Hedgehog ligand biogenesisTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERADTAS
R-HSA-5362798Release of Hh-Np from the secreting cellIEA
R-HSA-5362798Release of Hh-Np from the secreting cellTAS
R-HSA-5387390Hh mutants abrogate ligand secretionTAS
R-HSA-5632681Ligand-receptor interactionsTAS
R-HSA-5632681Ligand-receptor interactionsIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5635838Activation of SMOTAS
R-HSA-5658034HHAT G278V abrogates palmitoylation of Hh-NpTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29540668Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway. (2018 Mar 13)Qian WOncogenesis
28652248GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. (2017 Aug 15)Kasiri SCancer Res
26155468Agnathia Holoprosencephaly and Situs Inversus in A Neonate Born to an Alcoholic Mother. (2015 May)Goswami DJ Clin Diagn Res