Gene: COPS7B

64708
CSN7B|SGN7b
COP9 signalosome subunit 7B
protein-coding
2q37.1
Ensembl:ENSG00000144524 MIM:616010 Vega:OTTHUMG00000133228 UniprotKB:Q9H9Q2
NC_000002.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.581e-1 (AD)  8.513e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10185448chr2:231802592 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs13408416chr2:231796358 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCAR20.952
RNPS10.951
WDR50.945
PRCC0.942
ERAL10.942
WIPI20.94
ARL8A0.939
GDI10.939
ATG4B0.938
RNF1670.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.75
OR4F29-0.708
TFPI2-0.351
ARHGEF35-0.341
KLRB1-0.334
MTRNR2L6-0.325
MTRNR2L9-0.323
MTRNR2L10-0.314
IL18RAP-0.312
KCNJ15-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of COPS7B mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of COPS7B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of COPS7B gene27153756
C547126AZM551248AZM551248 results in decreased expression of COPS7B mRNA22323515
C006780bisphenol Abisphenol A results in increased expression of COPS7B mRNA25181051
C584509C646 compoundC646 compound results in increased expression of COPS7B mRNA26191083
D002945CisplatinCisplatin results in increased expression of COPS7B mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of COPS7B mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of COPS7B protein23301498
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COPS7B mRNA25613284
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of COPS7B mRNA"25554681|2562005
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of COPS7B mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COPS7B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COPS7B mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COPS7B mRNA25613284
D013849ThimerosalThimerosal results in increased expression of COPS7B mRNA27188386
C025643vinclozolinvinclozolin results in decreased expression of COPS7B mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18850735  19615732  20399188  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000338protein deneddylation-IDA19141280  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0008180COP9 signalosome-IBA21873635  
GO:0008180COP9 signalosome-IDA18850735  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-73894DNA RepairTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal