Gene: NUCKS1

64710
JC7|NUCKS
nuclear casein kinase and cyclin dependent kinase substrate 1
protein-coding
1q32.1
Ensembl:ENSG00000069275 MIM:611912 Vega:OTTHUMG00000035996 UniprotKB:Q9H1E3
NG_027548.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.906e-1 (AD)  2.058e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06665535chr1:205719527NUCKS1Promoter1.482e-4Alcohol use disorders26763658
cg24606240chr1:205720650NUCKS1Promoter2.717e-4Alcohol use disorders26763658
cg05262369chr1:205716365NUCKS12.410e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBR10.932
SEC630.926
ZMYND110.924
CSDE10.922
PLA2G12A0.92
RAD210.906
PTPN110.9
PCNP0.9
SAMD80.895
SEPT70.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.797
OR4F5-0.778
RAX2-0.223
EPPIN-0.215
CELSR1-0.213
MMP23B-0.194
NANOS2-0.186
CRYBB2-0.17
NPC1L1-0.165
SLC7A9-0.164

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NUCKS1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCKS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCKS1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NUCKS1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NUCKS1 mRNA16483693
D001151ArsenicArsenic affects the methylation of NUCKS1 gene25304211
C015001arsenitearsenite affects the expression of NUCKS1 mRNA22959463
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of NUCKS1 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of NUCKS1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of NUCKS1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of NUCKS1 mRNA20977926
C013418bromfenacoumbromfenacoum results in increased expression of NUCKS1 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of NUCKS1 mRNA26079696
D002104CadmiumCadmium results in decreased expression of NUCKS1 mRNA24284285
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NUCKS1 mRNA18560533
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NUCKS1 mRNA26472689
C037123cadmium sulfatecadmium sulfate results in decreased expression of NUCKS1 mRNA19274763
C084597chlorcyclizinechlorcyclizine results in decreased expression of NUCKS1 mRNA21058326
C100187chloropicrinchloropicrin results in increased expression of NUCKS1 mRNA26352163
D002994ClofibrateClofibrate results in decreased expression of NUCKS1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of NUCKS1 mRNA19320972
D003042CocaineCocaine results in decreased expression of NUCKS1 mRNA15009677|1671032
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of NUCKS1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of NUCKS1 mRNA19549813
C030973cupric oxidecupric oxide results in decreased phosphorylation of NUCKS1 protein25470785
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NUCKS1 mRNA19684285
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of NUCKS1 protein23811945
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of NUCKS1 protein23352502
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NUCKS1 mRNA14648872
D004147DioxinsDioxins affects the expression of NUCKS1 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NUCKS1 mRNA17555576
D018120FinasterideFinasteride results in increased expression of NUCKS1 mRNA24136188
D005472FluorouracilFluorouracil results in decreased expression of NUCKS1 protein15585135|1680352
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of NUCKS1 mRNA]15016801
D005485FlutamideFlutamide results in increased expression of NUCKS1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of NUCKS1 mRNA23649840
D003932HeroinHeroin results in decreased expression of NUCKS1 mRNA16710320
D017313FenretinideFenretinide results in decreased expression of NUCKS1 mRNA16671099
D017313FenretinideFenretinide results in decreased expression of NUCKS1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NUCKS1 mRNA20044591
D008345ManganeseManganese results in decreased expression of NUCKS1 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of NUCKS1 mRNA17175027
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NUCKS1 mRNA23649840
D009151Mustard GasMustard Gas results in increased phosphorylation of NUCKS1 protein19845377
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NUCKS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NUCKS1 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of NUCKS1 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of NUCKS1 mRNA22546817
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of NUCKS1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NUCKS1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of NUCKS1 mRNA17175027
D010634PhenobarbitalPhenobarbital results in decreased expression of NUCKS1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCKS1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NUCKS1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of NUCKS1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of NUCKS1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of NUCKS1 protein23718831
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NUCKS1 mRNA22698814
C005556propionaldehydepropionaldehyde results in decreased expression of NUCKS1 mRNA26079696
C010327salinomycinsalinomycin results in decreased expression of NUCKS1 mRNA19682730
D012643SeleniumSelenium results in decreased expression of NUCKS1 mRNA19244175
C016104sodium bichromatesodium bichromate results in increased expression of NUCKS1 mRNA25993096
D012999SomanSoman results in increased expression of NUCKS1 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of NUCKS1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NUCKS1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NUCKS1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUCKS1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of NUCKS1 mRNA19465110
C009495titanium dioxidetitanium dioxide results in increased expression of NUCKS1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NUCKS1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NUCKS1 gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of NUCKS1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NUCKS1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NUCKS1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of NUCKS1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of NUCKS1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in decreased methylation of NUCKS1 gene29154799
C025643vinclozolinvinclozolin affects the expression of NUCKS1 mRNA19015723
D014800VitalliumVitallium analog results in decreased expression of NUCKS1 mRNA23825117
D002762CholecalciferolCholecalciferol results in increased expression of NUCKS1 mRNA16508948

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003682chromatin binding-IDA26323318  
GO:0003690double-stranded DNA binding-IDA26323318  
GO:0003697single-stranded DNA binding-IEA-  
GO:0003723RNA binding-HDA22681889  
GO:0008134transcription factor binding-IPI25116364  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IMP26323318  
GO:0001678cellular glucose homeostasis-ISS-  
GO:0006275regulation of DNA replication-IMP26323318  
GO:0006325chromatin organization-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IC-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0019046release from viral latency-IMP25116364  
GO:0031297replication fork processing-IDA26323318  
GO:0035822gene conversion-NAS26323318  
GO:0036297interstrand cross-link repair-IMP26323318  
GO:0043923positive regulation by host of viral transcription-IGI25116364  
GO:0044829positive regulation by host of viral genome replication-IMP25116364  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046626regulation of insulin receptor signaling pathway-ISS-  
GO:0046628positive regulation of insulin receptor signaling pathway-IEA-  
GO:0060382regulation of DNA strand elongation-IMP26323318  
GO:0071481cellular response to X-ray-IMP26323318  
GO:1990968modulation by host of RNA binding by virus-IMP25116364  
GO:1990969modulation by host of viral RNA-binding transcription factor activity-IGI25116364  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-ISS-  
GO:0000790nuclear chromatin-IDA26323318  
GO:0005634nucleus-IDA11298763  17604136  25116364  26323318  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA17604136  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics