Gene: HS3ST6

64711
3-OST-6|HS3ST5
heparan sulfate-glucosamine 3-sulfotransferase 6
protein-coding
16p13.3
Ensembl:ENSG00000162040 Vega:OTTHUMG00000047860 UniprotKB:Q96QI5
NC_000016.10
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.479e-1 (AD)  6.318e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGR20.44
TFF10.425
BPIFB30.401
RNASE120.375
MUC5AC0.371
AKR1B100.364
BHLHE230.359
TFF20.358
SSX40.358
LAD10.355

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYH15-0.31
RNASEH2A-0.274
LY6G6F-0.258
AXDND1-0.25
KIF16B-0.248
C5-0.245
ZNF268-0.241
ARMC4-0.24
LCTL-0.237
DCHS2-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HS3ST6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HS3ST6 mRNA"27188386
C006632arsenic trioxidearsenic trioxide results in decreased expression of HS3ST6 mRNA25258189
D001280AtrazineAtrazine results in increased expression of HS3ST6 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of HS3ST6 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of HS3ST6 mRNA23125180
D002737ChloropreneChloroprene results in decreased expression of HS3ST6 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS3ST6 gene20938992
D016572CyclosporineCyclosporine results in decreased methylation of HS3ST6 promoter27989131
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of HS3ST6 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HS3ST6 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HS3ST6 mRNA27392435
C024565ethylene dichlorideethylene dichloride results in increased expression of HS3ST6 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS3ST6 gene20938992
D005839GentamicinsGentamicins results in decreased expression of HS3ST6 mRNA22061828
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HS3ST6 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS3ST6 gene20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HS3ST6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HS3ST6 mRNA"25554681
D009532NickelNickel results in decreased expression of HS3ST6 mRNA24768652
C028007nickel monoxidenickel monoxide results in increased expression of HS3ST6 mRNA19167457
D052638Particulate MatterParticulate Matter results in decreased expression of HS3ST6 mRNA28341207
D010936Plant ExtractsPlant Extracts results in decreased expression of HS3ST6 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of HS3ST6 mRNA24780913
C428725pyridabenpyridaben results in decreased expression of HS3ST6 mRNA22563483
D053260SootSoot results in decreased expression of HS3ST6 mRNA26551751
D014241TrichloroethyleneTrichloroethylene results in increased methylation of HS3ST6 gene27618143
D014635Valproic AcidValproic Acid results in increased expression of HS3ST6 mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased methylation of HS3ST6 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HS3ST6 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HS3ST6 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity-ISS-  
GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006024glycosaminoglycan biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-2022928HS-GAG biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal