Gene: SMYD3

64754
KMT3E|ZMYND1|ZNFN3A1|bA74P14.1
SET and MYND domain containing 3
protein-coding
1q44
Ensembl:ENSG00000185420 MIM:608783 Vega:OTTHUMG00000040508 UniprotKB:Q9H7B4
NC_000001.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.725e-1 (AD)  2.532e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2817475chr1:245798900 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EID20.946
AAGAB0.937
PCMT10.937
MOAP10.936
KIFAP30.935
CISD10.935
C1orf2160.934
SLC25A40.931
COPS40.931
NKIRAS10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.522
REST-0.508
CSAG1-0.493
CNN2-0.488
MTRNR2L6-0.484
HEY2-0.482
YES1-0.48
MAGEA12-0.475
CARD8-0.475
LATS2-0.473

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SMYD3 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SMYD3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SMYD3 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SMYD3 mRNA"22100608
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SMYD3 mRNA"22100608
D000082AcetaminophenSMYD3 gene polymorphism affects the susceptibility to Acetaminophen26104854
D000082AcetaminophenAcetaminophen affects the expression of SMYD3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SMYD3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SMYD3 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SMYD3 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SMYD3 mRNA24449571
D001151ArsenicArsenic affects the methylation of SMYD3 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of SMYD3 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMYD3 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMYD3 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMYD3 mRNA"26238291
D001599BerberineBerberine affects the expression of SMYD3 mRNA27311644
D004958EstradiolEstradiol affects the expression of SMYD3 mRNA23557687
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SMYD3 mRNA20660070
C044887beta-methylcholinebeta-methylcholine affects the expression of SMYD3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SMYD3 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of SMYD3 gene22576693
C006780bisphenol Abisphenol A affects the expression of SMYD3 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of SMYD3 mRNA19376846
D016572CyclosporineCyclosporine results in decreased expression of SMYD3 mRNA25562108
C014347decitabinedecitabine affects the expression of SMYD3 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SMYD3 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of SMYD3 mRNA23752591
D003907DexamethasoneDexamethasone results in increased expression of SMYD3 protein23752591
D003907DexamethasoneSMYD3 mutant form inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]23752591
D003907DexamethasoneSMYD3 mutant form inhibits the reaction [Dexamethasone results in increased expression of MSTN mRNA]23752591
D003907DexamethasoneSMYD3 mutant form inhibits the reaction [Dexamethasone results in increased expression of TRIM63 mRNA]23752591
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SMYD3 mRNA21266533
D002945CisplatinCisplatin affects the expression of SMYD3 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SMYD3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SMYD3 mRNA19561079|2739243
D002945CisplatinCisplatin results in decreased expression of SMYD3 mRNA25270620
D002945CisplatinCisplatin results in decreased expression of SMYD3 mRNA22023808
C000944dicrotophosdicrotophos results in decreased expression of SMYD3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of SMYD3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of SMYD3 mRNA25016146
D004147DioxinsDioxins affects the expression of SMYD3 mRNA20463971
C118739entinostatentinostat results in increased expression of SMYD3 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SMYD3 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of SMYD3 mRNA23649840
C492448ICG 001ICG 001 affects the expression of SMYD3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SMYD3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SMYD3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SMYD3 mRNA27392435
C410337K 7174K 7174 results in decreased expression of SMYD3 mRNA24086573
D008694MethamphetamineSMYD3 gene SNP affects the susceptibility to Methamphetamine18316681
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SMYD3 mRNA22100608
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SMYD3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SMYD3 mRNA22100608|2364984
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SMYD3 mRNA29191790
D009151Mustard GasMustard Gas results in decreased expression of SMYD3 mRNA25102026
D009151Mustard GasMustard Gas results in decreased expression of SMYD3 mRNA26392148
C029938nickel sulfatenickel sulfate results in decreased expression of SMYD3 mRNA22714537
D000073878Palm OilPalm Oil results in decreased expression of SMYD3 mRNA18042831
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SMYD3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of SMYD3 mRNA23557933
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SMYD3 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of SMYD3 mRNA21795739
D011794QuercetinQuercetin results in decreased expression of SMYD3 mRNA21632981
D015474IsotretinoinIsotretinoin results in increased expression of SMYD3 mRNA20436886
D012715Sesame OilSesame Oil results in increased expression of SMYD3 mRNA29191790
C017947sodium arsenitesodium arsenite affects the methylation of SMYD3 gene28589171
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SMYD3 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of SMYD3 mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SMYD3 mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of SMYD3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SMYD3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of SMYD3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SMYD3 mRNA17963808
D014638VanadatesVanadates results in increased expression of SMYD3 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of SMYD3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000993RNA polymerase II core binding-IEA-  
GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0005515protein binding-IPI25738358  
GO:0018024histone-lysine N-methyltransferase activity-IMP25738358  
GO:0018024histone-lysine N-methyltransferase activity-ISS-  
GO:0018024histone-lysine N-methyltransferase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006334nucleosome assembly-IEA-  
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0014904myotube cell development-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IEA-  
GO:0034968histone lysine methylation-IEA-  
GO:0045184establishment of protein localization-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0071549cellular response to dexamethasone stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA25738358  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18294291Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking. (2008 Apr)Wang HCancer Sci
27554136Smyd3-associated regulatory pathways in cancer. (2017 Feb)Giakountis ASemin Cancer Biol
29691085The SMYD3 VNTR 3/3 polymorphism confers an increased risk and poor prognosis of hepatocellular carcinoma in a Chinese population. (2018 May)Li RDPathol Res Pract