Gene: ATPAF1

64756
ATP11|ATP11p
ATP synthase mitochondrial F1 complex assembly factor 1
protein-coding
1p33
Ensembl:ENSG00000123472 MIM:608917 Vega:OTTHUMG00000007988 UniprotKB:Q5TC12
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.144e-1 (AD)  5.798e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1933932chr1:46643656 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GHITM0.939
ARL6IP10.935
ARL30.934
PEX190.932
PPT10.93
GPM6A0.924
PRNP0.918
FH0.916
NDUFB50.916
TSPAN70.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.786
OR4F29-0.746
TBX21-0.365
KLRB1-0.361
TFPI2-0.36
DPPA4-0.348
FOLR3-0.345
SLAMF6-0.344
GZMK-0.343
IL2RB-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of ATPAF1 mRNA"19095052
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ATPAF1 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ATPAF1 gene27153756
D001151ArsenicArsenic affects the methylation of ATPAF1 gene25304211
D001280AtrazineAtrazine results in decreased expression of ATPAF1 mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of ATPAF1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ATPAF1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ATPAF1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of ATPAF1 mRNA24084258
D002110CaffeineCaffeine results in decreased expression of ATPAF1 mRNA20864626
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ATPAF1 mRNA24763279
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ATPAF1 mRNA18355967
D016572CyclosporineCyclosporine results in decreased expression of ATPAF1 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ATPAF1 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of ATPAF1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of ATPAF1 mRNA25016146
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ATPAF1 protein23301498
D015025ZearalenoneZearalenone results in decreased expression of ATPAF1 mRNA19371625
D005485FlutamideFlutamide results in increased expression of ATPAF1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of ATPAF1 mRNA23649840
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ATPAF1 mRNA24763279
C016517indole-3-carbinolindole-3-carbinol affects the expression of ATPAF1 mRNA21396975
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of ATPAF1 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATPAF1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATPAF1 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ATPAF1 mRNA23649840
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of ATPAF1 mRNA20864626
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of ATPAF1 mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of ATPAF1 mRNA23892564
D010672PhenytoinPhenytoin results in decreased expression of ATPAF1 mRNA20345932
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ATPAF1 mRNA21061450
C045950propiconazolepropiconazole results in increased expression of ATPAF1 mRNA21278054
C017947sodium arsenitesodium arsenite affects the expression of ATPAF1 mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATPAF1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATPAF1 mRNA20399798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ATPAF1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ATPAF1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ATPAF1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ATPAF1 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11410595  
GO ID GO Term Qualifier Evidence PubMed
GO:0033615mitochondrial proton-transporting ATP synthase complex assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal