Gene: MARC1

64757
MOSC1
mitochondrial amidoxime reducing component 1
protein-coding
1q41
Ensembl:ENSG00000186205 MIM:614126 Vega:OTTHUMG00000037353 UniprotKB:Q5VT66
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.445e-1 (AD)  1.367e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11118607chr1:220811022 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A40.794
ABHD17C0.786
TTYH10.761
ZFYVE210.754
SNTA10.741
IL17D0.74
CPE0.734
SLC1A20.731
WIF10.726
SLC25A330.726

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.453
FCER2-0.431
OR4F29-0.411
GADL1-0.408
SFN-0.402
FCGR2C-0.392
SLC18A1-0.386
ALX3-0.385
FER1L6-0.385
GSDMA-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of MARC1 mRNA"21724226
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of MARC1 mRNA"21724226
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MARC1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MARC1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of MARC1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MARC1 mRNA21632981
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MARC1 mRNA21298039
D001379AzathioprineAzathioprine results in decreased expression of MARC1 mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of MARC1 mRNA22323515
C053561benzamidoxime[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of benzamidoxime22924387
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MARC1 mRNA22316170
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of MARC1 mRNA23410634
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MARC1 mRNA27339419
D009243NAD[MARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MARC1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of MARC1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MARC1 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of MARC1 mRNA19770486
D003976DiazinonDiazinon results in increased methylation of MARC1 gene22964155
D004026DieldrinDieldrin results in increased expression of MARC1 mRNA23041725
D004041Dietary FatsDietary Fats results in decreased expression of MARC1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MARC1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of MARC1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of MARC1 mRNA19638242
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of MARC1 mRNA"27840820
C118739entinostatentinostat results in increased expression of MARC1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC1 mRNA"27188386
D005485FlutamideFlutamide results in decreased expression of MARC1 mRNA24136188
D004397FonofosFonofos results in increased methylation of MARC1 promoter22847954
D005897GlafenineGlafenine results in decreased expression of MARC1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of MARC1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MARC1 mRNA23410634
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MARC1 mRNA26752646
D008694MethamphetamineMARC1 gene SNP affects the susceptibility to Methamphetamine18316681
C010737N(4)-hydroxycytidine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of N(4)-hydroxycytidine22924387
C021202N(4)-hydroxycytosine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of N(4)-hydroxycytosine22924387
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MARC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MARC1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of MARC1 mRNA24136188
D009532NickelNickel results in decreased expression of MARC1 mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of MARC1 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MARC1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MARC1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MARC1 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of MARC1 mRNA18042831
D010278ParathionParathion results in increased methylation of MARC1 promoter22847954
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MARC1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MARC1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of MARC1 mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of MARC1 mRNA17426115|1830175
D011374ProgesteroneProgesterone results in decreased expression of MARC1 mRNA21540246
C045950propiconazolepropiconazole results in decreased expression of MARC1 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of MARC1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MARC1 mRNA23221170
D053260SootSoot results in increased expression of MARC1 mRNA26551751
C059873sulfamethoxazole hydroxylamine[MARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
C012568terbufosterbufos results in increased methylation of MARC1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MARC1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MARC1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MARC1 mRNA21724226
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of MARC1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of MARC1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of MARC1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MARC1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MARC1 mRNA25729387
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of MARC1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MARC1 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of MARC1 mRNA23410634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008940nitrate reductase activity-IDA20861021  
GO:0030151molybdenum ion binding-IDA20861021  
GO:0030170pyridoxal phosphate binding-IEA-  
GO:0043546molybdopterin cofactor binding-IDA20861021  
GO ID GO Term Qualifier Evidence PubMed
GO:0042126nitrate metabolic process-IDA20861021  
GO:0051410detoxification of nitrogen compound-NAS20861021  
GO:0055114oxidation-reduction process-IDA20861021  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-ISS20861021  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal