Gene: SI

6476
-
sucrase-isomaltase
protein-coding
3q26.1
Ensembl:ENSG00000090402 MIM:609845 Vega:OTTHUMG00000158065 UniprotKB:P14410
NG_017043.1
PubMed
CD|OD|ND|AD
78   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.299e-1 (AD)  5.587e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHLA10.565
PLEKHS10.549
LRRC150.536
DMBX10.527
TNFSF180.522
FAM47B0.518
ALDH1A20.517
SLC14A20.509
CHRNB40.506
PMM20.501

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD8-0.243
APOA1-0.234
FXYD3-0.229
SMIM1-0.225
KLRC3-0.223
MYBPC1-0.206
SFTPC-0.206
BGLAP-0.204
AZGP1-0.203
FOXO4-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297284-phenylenediamine4-phenylenediamine results in increased expression of SI mRNA16314067
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SI gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SI mRNA16483693
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of SI mRNA17639512
D001241AspirinAspirin results in increased activity of SI protein9399670
D001241AspirinAspirin results in decreased activity of SI protein18604318
C406592azaspiracidazaspiracid results in decreased expression of SI mRNA28939011
D001599BerberineBerberine results in decreased expression of SI mRNA20229011
D001599BerberineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]20229011
D001599BerberineBerberine results in decreased expression of SI mRNA20229011
D001622Betaine[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA28445388
C006780bisphenol Abisphenol A results in decreased expression of SI mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of SI mRNA28445388
D000068579CelecoxibCelecoxib results in increased activity of SI protein18604318
D002794Choline[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA28445388
D004026DieldrinDieldrin results in decreased expression of SI mRNA20584760
D002117CalcitriolCalcitriol results in decreased expression of SI mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SI mRNA21592394
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of SI mRNA16314067
D004726EndosulfanEndosulfan results in increased activity of SI protein6180524
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SI mRNA15212814
C017690fenvaleratefenvalerate results in decreased activity of SI protein12568456
D005492Folic Acid[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA28445388
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of SI mRNA20846436
D005632FructoseFructose results in increased expression of SI mRNA17786952
D005632FructoseFructose results in increased expression of SI mRNA10222385|1124247
C039281furanfuran results in increased expression of SI mRNA27387713
D005947GlucoseGlucose results in increased expression of SI mRNA17786952
D005990GlycerolGlycerol results in increased expression of SI mRNA10222385
D001556LindaneLindane results in decreased activity of SI protein92405
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]20229011
C005273naringeninnaringenin binds to and results in decreased activity of SI protein24412302
C005273naringeninnaringenin results in decreased activity of SI protein24412302
C496111nimbidiolnimbidiol results in decreased activity of SI protein22803678
C012655nimesulidenimesulide affects the activity of SI protein18604318
D010269ParaquatParaquat results in decreased expression of SI mRNA18198484
C003117phosalonephosalone results in decreased activity of SI protein92405
D011192Potassium DichromatePotassium Dichromate results in increased expression of SI mRNA23608068
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of SI mRNA17639512
D012969Sodium FluorideSodium Fluoride results in increased expression of SI mRNA27862939
D013395SucroseSucrose results in increased expression of SI mRNA10222385|1124247
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SI mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SI mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SI mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SI mRNA21570461
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of SI mRNA"17951470
D014805Vitamin B 12[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA28445388
C102817voglibosevoglibose results in decreased activity of SI protein12560160
C074508zinc methioninezinc methionine results in increased activity of SI protein15936645
C074508zinc methioninezinc methionine results in increased expression of SI mRNA15936645

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004558alpha-1,4-glucosidase activity-EXP20356844  
GO:0004574oligo-1,6-glucosidase activity-IEA-  
GO:0004575sucrose alpha-glucosidase activity-TAS-  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0044245polysaccharide digestion-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-TAS1717481  
GO:0005886plasma membrane-TAS-  
GO:0005903brush border-TAS1717481  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00500Starch and sucrose metabolism
hsa01100Metabolic pathways
hsa04973Carbohydrate digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseIEA
R-HSA-1643685DiseaseTAS
R-HSA-189085Digestion of dietary carbohydrateTAS
R-HSA-5659898Intestinal saccharidase deficienciesIEA
R-HSA-5659898Intestinal saccharidase deficienciesTAS
R-HSA-5663084Diseases of carbohydrate metabolismIEA
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5668914Diseases of metabolismIEA
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23814338The Association of Sleep Duration, Mental Health, and Health Risk Behaviors among U.S. Afghanistan/Iraq Era Veterans. (2013 Jul 1)Swinkels CMSleep
19157170Combined "pro-atherosclerotic" variants of the ACE and APOE genes increase the risk of the coronary artery disease associated with the presence of cigarette smoking. (2008 Dec)Zak IActa Cardiol
25296021Nicotine stimulates nerve growth factor in lung fibroblasts through an NFkappaB-dependent mechanism. (2014)Wongtrakool CPLoS One
16770336Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. (2006 Aug)Lerer EMol Psychiatry
28529598Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan. (2017 May)Yamamoto YOncol Lett
28031420Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion. (2017 Mar)Lorenzo CDiabetes Care
28983601PKCzeta, MMP2 and MMP9 expression in lung adenocarcinoma and association with a metastatic phenotype. (2017 Dec)Cai XMol Med Rep
23818972Bone mineral density, bone turnover markers and fractures in patients with systemic sclerosis: a case control study. (2013)Atteritano MPLoS One
23189925Acute and chronic effects of smoking on myocardial function in healthy heavy smokers: a study of Doppler flow, Doppler tissue velocity, and two-dimensional speckle tracking echocardiography. (2013 Mar)Farsalinos KEchocardiography
10435155Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose. (1999 Mar)Tanimoto KOral Oncol
26897098Association of polymorphisms of adiponectin gene promoter-11377C/G, glutathione peroxidase-1 gene C594T, and cigarette smoking in nonalcoholic fatty liver disease. (2016 Apr)Zhang CXJ Chin Med Assoc
12696393[Cardiovascular reactivity and cardiovascular risk factors in normotensive individuals of less than 40 years of age]. (2003 Jan-Feb)Benet Rodriguez MRev Esp Salud Publica
867327A difference in the composition of bronchial mucus between smokers and non-smokers. (1977 Apr)Kollerstrom NThorax
18787943The risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia is additionally increased by the presence of the AT1R gene 1166C allele. (2008 Dec)Niemiec PBiochem Genet
20808433Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. (2010 Aug 16)Li MDPLoS One
25095634[The analysis of the influence of short term physical effort on selected endothelial function parameters and blood vessels stiffness features among young and healthy men]. (2014 Jun)Jerzykowska SPol Merkur Lekarski
27323445[Randomized Controlled Clinical Trials for Acupuncture Treatment of Abdominal Obesity]. (2016 Apr)Liang CMZhen Ci Yan Jiu
25402559IGF2R expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. (2014)Tian ZCell Physiol Biochem
20733118Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. (2010 Sep 8)Lee CHJ Natl Cancer Inst
26733033[The impact of interaction between alcohol consumption and obesity on incident hypertension]. (2015 Aug)Chen DZhonghua Yu Fang Yi Xue Za Zhi
8988947Relation of body mass and alcohol, nutrient, fiber, and caffeine intakes to blood pressure in the special intervention and usual care groups in the Multiple Risk Factor Intervention Trial. (1997 Jan)Stamler JAm J Clin Nutr
23623598Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population. (2014 Jan)Wang TCInt J Hyg Environ Health
21127031A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticism. (2011 Feb)Ellis JANicotine Tob Res
21752868PTPN22 R620W genotype-phenotype correlation analysis and gene-environment interaction study in early rheumatoid arthritis: results from the ESPOIR cohort. (2011 Oct)Salliot CRheumatology (Oxford)
27483394Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure. (2016 Oct)Claria JHepatology
29118461Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease. (2017)Iwanicka JDis Markers
20011043Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation. (2009 Dec 9)Garbin UPLoS One
23110878Individual differences in amygdala reactivity following nicotinic receptor stimulation in abstinent smokers. (2013 Feb 1)Sutherland MTNeuroimage
7183084Coronary prone behavior and cardiovascular reactions during the German version of the type A interview and during a quiz. (1982)Schmidt THAct Nerv Super (Praha)
26990518Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two-Year Follow-up Period in Recent-Onset Spondyloarthritis. (2016 Aug)Dougados MArthritis Rheumatol
23219715Enhancement of cancer stem-like and epithelial-mesenchymal transdifferentiation property in oral epithelial cells with long-term nicotine exposure: reversal by targeting SNAIL. (2013 Feb 1)Yu CCToxicol Appl Pharmacol
19921817Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors. (2010 Jan 13)Shih YLJ Agric Food Chem
23667618Independent and supra-additive effects of alcohol consumption, cigarette smoking, and metabolic syndrome on the elevation of serum liver enzyme levels. (2013)Park EYPLoS One
19661247Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. (2009 Nov 1)Deshmukh HSAm J Respir Crit Care Med
12772461[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]. (2002 Oct)Lei DZhonghua Er Bi Yan Hou Ke Za Zhi
17264953Sex-specific, independent associations of insulin resistance with erythrocyte sedimentation rate in apparently healthy subjects. (2007 Feb)Lopez-Bermejo AThromb Haemost
26365964Interaction of Polymorphisms of Resistin Gene Promoter -420C/G, Glutathione Peroxidase -1 Gene Pro198Leu and Cigarette Smoking in Nonalcoholic Fatty Liver Disease. (2015 Sep 20)Zhang CXChin Med J (Engl)
26354764Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration. (2015 Nov)Meyers KJOphthalmology
23216702Components of metabolic syndrome and 5-year change in insulin clearance - the Insulin Resistance Atherosclerosis Study. (2013 May)Lee CCDiabetes Obes Metab
29068985Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease. (2017 Oct)Xu FMedicine (Baltimore)
23258737Impact of aluminum exposure on lung. (2015 Jan)Elserougy SToxicol Ind Health
21316925An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. (2011 Apr)Tsuji GJ Dermatol Sci
12444896The risk of myocardial infarction is enhanced by a synergistic interaction between serum insulin and smoking. (2002 Nov)Bennet AMEur J Endocrinol
18302507Assessment of the 10-year probability of osteoporotic hip fracture combining clinical risk factors and heel bone ultrasound: the EPISEM prospective cohort of 12,958 elderly women. (2008 Jul)Hans DJ Bone Miner Res
19890259Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. (2010 Feb)Wang JNeuropsychopharmacology
26740398Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function". (2016 Aug 15)Nestler EJBrain Res
22832964Genome-wide meta-analyses of smoking behaviors in African Americans. (2012 May 22)David SPTransl Psychiatry
26312598Association between vitamin D status and age-related macular degeneration by genetic risk. (2015 Oct)Millen AEJAMA Ophthalmol
24427122The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking. (2014)Butler TRFront Integr Neurosci
29391787Epidemiological study of PM2.5 and risk of COPD-related hospital visits in association with particle constituents in Chuncheon, Korea. (2018)Jo YSInt J Chron Obstruct Pulmon Dis
21777168The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia. (2011 Aug)Niemiec PBiomarkers
22495109Association between asthma medications and suicidal ideation in adult asthmatics. (2012 Jul)Favreau HRespir Med
18409009The M235T polymorphism of the AGT gene modifies the risk of coronary artery disease associated with the presence of hypercholesterolemia. (2008)Niemiec PEur J Epidemiol
24412684Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine. (2014 Apr 1)Szabo STBehav Brain Res
29414121Sacred Maya incense, copal (Protium copal - Burseraceae), has antianxiety effects in animal models. (2018 Apr 24)Merali ZJ Ethnopharmacol
24169876Sources of indoor air pollution in New York City residences of asthmatic children. (2014 May-Jun)Habre RJ Expo Sci Environ Epidemiol
23658367Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population. (2013 Jul)Jin ZYCancer Prev Res (Phila)
19700159Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study. (2010 Jan)Heiskanen MAtherosclerosis
18294050Modification of the coronary artery disease risk associated with the presence of traditional risk factors by insertion/deletion polymorphism of the ACE gene. (2007 Winter)Niemiec PGenet Test
15274052Association study of the Epac gene and tobacco smoking and nicotine dependence. (2004 Aug 15)Chen XAm J Med Genet B Neuropsychiatr Genet
29199707Evolving epidemiology of lung cancer in India: Reducing non-small cell lung cancer-not otherwise specified and quantifying tobacco smoke exposure are the key. (2017 Jan-Mar)Kaur HIndian J Cancer
25941919Gene-gene interaction of mu-opioid receptor and GluR5 kainate receptor subunit is associated with smoking behavior in a Greek population: presence of a dose allele effect. (2015 Jun)Misailidis GDrug Metab Pers Ther
16585388Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes. (2006 Apr 11)Festa ACirculation
22006218Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. (2012 Jun)Yoon DHum Genet
16798059Expression of human telomerase reverse transcriptase (hTERT) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. (2007 Feb)Chen HHOral Oncol
14988302Insulin sensitivity, insulinemia, and coronary artery disease: the Insulin Resistance Atherosclerosis Study. (2004 Mar)Rewers MDiabetes Care
28024695Tumor B7-H3 (CD276) expression and smoking history in relation to lung adenocarcinoma prognosis. (2017 Jan)Inamura KLung Cancer
22614351The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy. (2012 May 9)Wang ZCGenet Mol Res
12679473CD14 monocyte receptor, involved in the inflammatory cascade, and insulin sensitivity. (2003 Apr)Fernandez-Real JMJ Clin Endocrinol Metab
17427187Why do young women smoke? IV. Role of genetic variation in the dopamine transporter and lifetime traumatic experience. (2007 Jun 5)Segman RHAm J Med Genet B Neuropsychiatr Genet
17711714[Association of the MspI polymorphism of cytochrome P4501A1 gene and smoking to the susceptibility to coronary artery disease]. (2007 Jun)Zhang XMZhonghua Xin Xue Guan Bing Za Zhi
17284169RhoA, encoding a Rho GTPase, is associated with smoking initiation. (2007 Nov)Chen XGenes Brain Behav
20688737Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy. (2010 Dec)Nakanishi HInvest Ophthalmol Vis Sci
12839677[Changes of the actin and transforming growth factor-beta1 expression in the small airways of the rat with chronic obstructive lung disease]. (2003 Apr)Ge XNZhonghua Bing Li Xue Za Zhi
18038590[Polymorphic variants of a surfactant protein C gene in patients with chronic obstructive pulmonary disease]. (2007)Tsvetkova OATer Arkh
23748423Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. (2013 Aug 15)Zhou MSAm J Physiol Heart Circ Physiol
12015038[Relationship between polymorphism of N-acetyltransferase 2 and genetic susceptibility to laryngeal carcinoma]. (2002 Mar)Lei DZhonghua Zhong Liu Za Zhi
29565649Risk factors for radiation pneumonitis after stereotactic radiation therapy for lung tumours: clinical usefulness of the planning target volume to total lung volume ratio. (2018 Jun)Ueyama TBr J Radiol