Gene: SIAH1

6477
SIAH1A
siah E3 ubiquitin protein ligase 1
protein-coding
16q12.1
Ensembl:ENSG00000196470 MIM:602212 Vega:OTTHUMG00000175417 UniprotKB:Q8IUQ4
NG_029599.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.835e-2 (AD)  4.845e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BRIX10.849
UBE2B0.829
MYNN0.827
DPM10.822
PSMG20.82
MRPS310.812
PSMD120.811
BUB30.811
TSG1010.808
ZCCHC70.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.519
OR4F29-0.48
KCNK5-0.258
IGF2-0.246
RNF223-0.241
GPR17-0.229
CXCL17-0.228
NOTCH3-0.218
CYSLTR2-0.216
NXNL1-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of SIAH1 mRNA"19936915
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SIAH1 mRNA24449571
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SIAH1 mRNA"20382639
C044887beta-methylcholinebeta-methylcholine affects the expression of SIAH1 mRNA21179406
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of SIAH1 mRNA23410634
D019327Copper SulfateCopper Sulfate results in increased expression of SIAH1 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SIAH1 mRNA20421190
D016572CyclosporineCyclosporine results in increased expression of SIAH1 mRNA20106945|2556210
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SIAH1 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of SIAH1 mRNA26924002
D000431EthanolEthanol results in increased expression of SIAH1 protein27270636
D000431EthanolSIAH1 protein promotes the reaction [Ethanol results in increased expression of and results in increased phosphorylation of TP53 protein]27270636
D000431EthanolSIAH1 protein promotes the reaction [Ethanol results in increased expression of BAK1 protein]27270636
D000431EthanolSIAH1 protein promotes the reaction [Ethanol results in increased expression of BBC3 protein]27270636
D000431EthanolSIAH1 protein promotes the reaction [Ethanol results in increased expression of CASP3 protein modified form]27270636
D000431EthanolSIAH1 protein results in increased susceptibility to Ethanol27270636
D015025ZearalenoneZearalenone results in decreased expression of SIAH1 mRNA19371625
D005557FormaldehydeFormaldehyde results in decreased expression of SIAH1 mRNA20655997
D006582HexachloropheneHexachlorophene results in increased expression of SIAH1 mRNA16735606
D006582HexachloropheneSIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein]16735606
D017313FenretinideFenretinide results in increased expression of SIAH1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SIAH1 mRNA23410634
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SIAH1 mRNA25613284
C410337K 7174K 7174 results in increased expression of SIAH1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of SIAH1 mRNA28988120
C018091maduramicinmaduramicin results in increased expression of SIAH1 mRNA29128925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SIAH1 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SIAH1 mRNA26924002
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of SIAH1 mRNA26314263
C025589ochratoxin Aochratoxin A results in decreased expression of SIAH1 mRNA26314263
D011192Potassium DichromatePotassium Dichromate results in increased expression of SIAH1 mRNA11678601
D011794QuercetinQuercetin results in decreased expression of SIAH1 mRNA15309432
D012110ReserpineReserpine results in increased expression of SIAH1 mRNA19607803
C059514resveratrolresveratrol results in decreased expression of SIAH1 mRNA19371625
D012643SeleniumSelenium results in decreased expression of SIAH1 mRNA19244175
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SIAH1 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of SIAH1 mRNA27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SIAH1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of SIAH1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SIAH1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SIAH1 mRNA23179753|2352703
D014750VincristineVincristine results in decreased expression of SIAH1 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of SIAH1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of SIAH1 mRNA23410634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-IMP21185211  
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI11389839  11483518  12421809  16085652  16230351  19549727  
21078624  21185211  21516116  21878328  21988832  23840749  
25241761  25416956  
GO:0008022protein C-terminus binding-IPI11389840  
GO:0008270zinc ion binding-IDA11863358  16085652  
GO:0008270zinc ion binding-ISS-  
GO:0031624ubiquitin conjugating enzyme binding-IBA21873635  
GO:0042802identical protein binding-IPI21988832  22493164  25416956  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IDA23001567  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0006511ubiquitin-dependent protein catabolic process-IDA23001567  
GO:0006511ubiquitin-dependent protein catabolic process-ISS-  
GO:0006915apoptotic process-TAS9403064  
GO:0007049cell cycle-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0007399nervous system development-TAS9334332  
GO:0007411axon guidance-TAS-  
GO:0009653anatomical structure morphogenesis-TAS9403064  
GO:0030163protein catabolic process-IDA11389840  
GO:0031648protein destabilization-IEA-  
GO:0043065positive regulation of apoptotic process-IDA21185211  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-ISS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0051402neuron apoptotic process-ISS-  
GO:2001244positive regulation of intrinsic apoptotic signaling pathway-IMP21185211  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9334332  
GO:0005769early endosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0030877beta-catenin destruction complex-IDA16085652  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-373752Netrin-1 signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-977225Amyloid fiber formationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26022259Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine. (2015)Harraz MMCNS Neurol Disord Drug Targets