Gene: C6orf106

64771
FP852|dJ391O22.4
chromosome 6 open reading frame 106
protein-coding
6p21.31
Ensembl:ENSG00000196821 MIM:612217 Vega:OTTHUMG00000014553 UniprotKB:Q9H6K1
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
2.299e-1 (AD)  7.338e-1 (ND)   (Frontal_Cortex)
9.642e-1 (AD)  8.320e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATXN7L30.958
SEPT30.956
CAMTA20.95
CDK160.946
POU6F10.945
TTC7B0.944
EPB41L10.942
RNF1570.942
IQSEC10.942
CALM30.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.684
OR4F29-0.648
TFPI2-0.418
IL18RAP-0.412
KCNJ15-0.387
C1orf87-0.384
CST7-0.377
S100A12-0.376
CXCR2-0.375
C9orf135-0.374

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C016601afimoxifeneafimoxifene results in decreased expression of C6ORF106 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of C6ORF106 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of C6ORF106 gene25435355
D004958EstradiolEstradiol results in decreased expression of C6ORF106 mRNA16514628
D004958EstradiolEstradiol results in increased expression of C6ORF106 mRNA19167446
C018021cobaltous chloridecobaltous chloride results in increased expression of C6ORF106 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of C6ORF106 mRNA19549813
C070081fulvestrantfulvestrant results in decreased expression of C6ORF106 mRNA16514628
D018021Lithium ChlorideLithium Chloride results in increased expression of C6ORF106 mRNA23527032
C029938nickel sulfatenickel sulfate results in increased expression of C6ORF106 mRNA22714537
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of C6ORF106 mRNA16514628
D012643SeleniumSelenium results in increased expression of C6ORF106 mRNA19244175
D013849ThimerosalThimerosal results in decreased expression of C6ORF106 mRNA27188386
D014212TretinoinTretinoin results in increased expression of C6ORF106 mRNA23724009
D014635Valproic AcidValproic Acid results in increased expression of C6ORF106 mRNA28001369|2915479
C111237vorinostatvorinostat results in decreased expression of C6ORF106 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0043130ubiquitin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0016236macroautophagy-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000407phagophore assembly site-IBA21873635  
GO:0005575cellular_component-ND-  
GO:0005776autophagosome-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26683835Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. (2015 Dec 18)Ahmad SBMC Med Genet