Gene: MTHFSD

64779
-
methenyltetrahydrofolate synthetase domain containing
protein-coding
16q24.1
Ensembl:ENSG00000103248 MIM:616820 Vega:OTTHUMG00000176480 UniprotKB:Q2M296
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.624e-1 (AD)  6.834e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GOLGA10.816
NLRX10.815
IVD0.798
SLC9A80.788
RECQL50.784
ATF6B0.777
GORASP10.776
FAM160A20.776
MKS10.775
SPPL2B0.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
OR4F29-0.519
MTRNR2L9-0.265
MTRNR2L6-0.263
PRAMEF8-0.262
KRTAP1-1-0.238
SLURP1-0.238
PTH-0.225
IYD-0.224
KLRC2-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of MTHFSD mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTHFSD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTHFSD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTHFSD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTHFSD mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MTHFSD mRNA25064622
D000638AmiodaroneAmiodarone affects the expression of MTHFSD mRNA25064622
D002746ChlorpromazineChlorpromazine affects the expression of MTHFSD mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFSD mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of MTHFSD mRNA19549813
D016572CyclosporineCyclosporine affects the expression of MTHFSD mRNA25064622
D004041Dietary FatsDietary Fats results in decreased expression of MTHFSD mRNA25016146
C118739entinostatentinostat results in decreased expression of MTHFSD mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTHFSD mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MTHFSD mRNA25064622
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MTHFSD mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFSD mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of MTHFSD mRNA23649840
D007854LeadLead results in decreased expression of MTHFSD mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MTHFSD mRNA"24972896
D008627Mercuric ChlorideMercuric Chloride affects the expression of MTHFSD mRNA20353558
D008694MethamphetamineMethamphetamine results in increased expression of MTHFSD mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFSD mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MTHFSD mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MTHFSD mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MTHFSD mRNA"20188158
D010269ParaquatParaquat affects the expression of MTHFSD mRNA25064622
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTHFSD mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of MTHFSD mRNA16214954
D013752TetracyclineTetracycline affects the expression of MTHFSD mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of MTHFSD mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of MTHFSD mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTHFSD mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MTHFSD mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MTHFSD mRNA26272509|2800136
D014635Valproic AcidValproic Acid affects the expression of MTHFSD mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MTHFSD gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis