Gene: SIAH2

6478
hSiah2
siah E3 ubiquitin protein ligase 2
protein-coding
3q25.1
Ensembl:ENSG00000181788 MIM:602213 Vega:OTTHUMG00000159847 UniprotKB:O43255
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.413e-1 (AD)  7.685e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEDD20.911
CCT40.908
PPID0.908
AHSA10.906
C16orf720.905
DNAJB60.904
CACYBP0.901
NUDT90.896
YARS0.895
HSPH10.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.539
OR4F29-0.494
KLRB1-0.43
KLRF1-0.401
CTNNA3-0.386
ASB4-0.383
KLF17-0.382
MYOM1-0.38
P2RY14-0.379
IL18RAP-0.368

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SIAH2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SIAH2 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SIAH2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIAH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIAH2 mRNA"27188386
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of SIAH2 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SIAH2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SIAH2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SIAH2 mRNA16483693
D001151ArsenicArsenic affects the methylation of SIAH2 gene25304211
D001241AspirinAspirin results in decreased expression of SIAH2 mRNA15928584
D001280AtrazineAtrazine results in increased expression of SIAH2 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SIAH2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SIAH2 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SIAH2 mRNA20061341
D004958EstradiolEGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]18629630
D004958EstradiolEGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 protein]18629630
D004958Estradiol[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA18629630
D004958Estradiol[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 protein18629630
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SIAH2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SIAH2 mRNA18629630|1961957
D004958EstradiolEstradiol results in increased expression of SIAH2 protein18629630
D004958EstradiolICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]18629630
D004958EstradiolEstradiol results in increased expression of SIAH2 mRNA22467019
C095105bexarotenebexarotene results in decreased expression of SIAH2 mRNA17178900
C006780bisphenol Abisphenol A results in increased expression of SIAH2 mRNA28711546
C006780bisphenol Abisphenol A results in increased expression of SIAH2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of SIAH2 mRNA24247028
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of SIAH2 mRNA15878706
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SIAH2 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SIAH2 mRNA20061341
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of SIAH2 mRNA25596134
C059262cidofovircidofovir affects the expression of SIAH2 mRNA25596134
D002922CiguatoxinsCiguatoxins affects the expression of SIAH2 mRNA18353800
D004002Clodronic AcidClodronic Acid results in increased expression of SIAH2 mRNA25596134
D002996ClomipheneClomiphene results in decreased expression of SIAH2 mRNA26865669
C018021cobaltous chloridecobaltous chloride results in increased expression of SIAH2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of SIAH2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SIAH2 mRNA20106945
D003976DiazinonDiazinon affects the expression of SIAH2 mRNA22546817
D002945CisplatinCisplatin results in increased expression of SIAH2 mRNA25596134|2759478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SIAH2 mRNA21318169
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SIAH2 mRNA19371625|2686566
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased expression of SIAH2 mRNA27720938
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of SIAH2 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of SIAH2 mRNA21233418
D004970EstroneEstrone results in increased expression of SIAH2 mRNA26865669
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SIAH2 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIAH2 mRNA17942748
D008656MestranolMestranol results in increased expression of SIAH2 mRNA26865669
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SIAH2 mRNA23649840
D011345FenofibrateFenofibrate affects the expression of SIAH2 mRNA25596134
C070081fulvestrantfulvestrant results in decreased expression of SIAH2 mRNA26865669
C039281furanfuran results in increased methylation of SIAH2 gene22079235
D019833GenisteinGenistein results in increased expression of SIAH2 mRNA23019147|2686566
D006589HexestrolHexestrol results in increased expression of SIAH2 mRNA26865669
C051781ICI 164384ICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]18629630
C051781ICI 164384ICI 164384 results in decreased expression of SIAH2 mRNA18629630
C051781ICI 164384SIAH2 protein affects the susceptibility to ICI 16438418629630
D007069IfosfamideIfosfamide results in increased expression of SIAH2 mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SIAH2 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of SIAH2 protein17337753
D007854LeadLead affects the expression of SIAH2 mRNA28903495
C045463leflunomideleflunomide results in increased expression of SIAH2 mRNA28988120
D008687MetforminMetformin results in decreased expression of SIAH2 mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of SIAH2 mRNA19564919
D008731MethoxychlorMethoxychlor results in increased methylation of SIAH2 gene23303685
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SIAH2 mRNA23649840
D009281NaphthalenesNaphthalenes results in increased expression of SIAH2 protein17337753
C570897NSC668394NSC668394 results in increased expression of SIAH2 mRNA27137931
C016340o,p'-DDT"o,p'-DDT results in increased expression of SIAH2 mRNA"19371625
D010100OxygenOxygen deficiency results in increased expression of SIAH2 mRNA25596134
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SIAH2 mRNA18593933
C006253pirinixic acidpirinixic acid results in increased expression of SIAH2 mRNA18301758|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of SIAH2 mRNA]21318169
D010936Plant ExtractsPlant Extracts results in decreased expression of SIAH2 mRNA23557933
C010313pseudocumenepseudocumene results in increased expression of SIAH2 protein17337753
C030984pyrenepyrene results in decreased expression of SIAH2 mRNA15240111
D011794QuercetinQuercetin results in decreased expression of SIAH2 mRNA15309432
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of SIAH2 mRNA26865669
C059514resveratrol[resveratrol results in decreased expression of HIF1A protein] which results in decreased susceptibility to SIAH2 mRNA24282676
D012822Silicon DioxideSilicon Dioxide results in increased expression of SIAH2 mRNA19073995
D012999SomanSoman results in increased expression of SIAH2 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of SIAH2 mRNA17555576
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SIAH2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SIAH2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SIAH2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIAH2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SIAH2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SIAH2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SIAH2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SIAH2 mRNA28111298
D014241TrichloroethyleneTrichloroethylene results in increased expression of SIAH2 mRNA19448997
C057693troglitazonetroglitazone results in decreased expression of SIAH2 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of SIAH2 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIAH2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SIAH2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SIAH2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SIAH2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SIAH2 mRNA17292431
D014750VincristineVincristine results in increased expression of SIAH2 mRNA23649840
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SIAH2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-TAS10207103  
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI21586138  21659512  23840749  25438054  
GO:0008270zinc ion binding-IEA-  
GO:0031624ubiquitin conjugating enzyme binding-IBA21873635  
GO:0031624ubiquitin conjugating enzyme binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0006511ubiquitin-dependent protein catabolic process-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007264small GTPase mediated signal transduction-TAS10207103  
GO:0007411axon guidance-TAS-  
GO:0016579protein deubiquitination-TAS-  
GO:0031396regulation of protein ubiquitination-IEA-  
GO:0043066negative regulation of apoptotic process-IMP21586138  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP21586138  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0044257cellular protein catabolic process-IGI12952940  
GO:0044267cellular protein metabolic process-TAS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IGI12952940  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IMP21586138  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS10207103  
GO:0005769early endosome-IEA-  
GO:0005829cytosol-IDA21586138  
GO:0005829cytosol-TAS-  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-373752Netrin-1 signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-977225Amyloid fiber formationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20552680Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood. (2010 Oct 5)Bousman CAAm J Med Genet B Neuropsychiatr Genet