Gene: DEPTOR

64798
DEP.6|DEPDC6
DEP domain containing MTOR interacting protein
protein-coding
8q24.12
Ensembl:ENSG00000155792 MIM:612974 Vega:OTTHUMG00000165052 UniprotKB:Q8TB45
NC_000008.11
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.893e-1 (AD)  1.397e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9649948chr8:119901295 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPE30.852
AGTPBP10.846
IFT800.843
TTLL70.84
RAPGEF50.838
STK390.831
KIAA1324L0.831
MTIF20.828
HBS1L0.827
BACE10.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.454
OR4F5-0.448
WNT7B-0.372
SYPL2-0.367
KCNK5-0.363
HKDC1-0.357
ADORA2B-0.354
TLCD1-0.351
LRAT-0.35
SOCS1-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of DEPTOR mRNA"20453058
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DEPTOR mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DEPTOR mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DEPTOR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DEPTOR mRNA27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of DEPTOR mRNA21757418
D013196Dihydrotestosteronebicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of DEPTOR mRNA]26558456
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of DEPTOR mRNA26558456
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of DEPTOR protein26558456
D000638AmiodaroneAmiodarone results in increased expression of DEPTOR mRNA19774075
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of DEPTOR mRNA"25351596
C487081belinostatbelinostat results in increased expression of DEPTOR mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DEPTOR mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DEPTOR mRNA20713471
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DEPTOR mRNA19619570
D004958EstradiolEstradiol results in increased expression of DEPTOR mRNA19619570|2532141
C053541bicalutamidebicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of DEPTOR mRNA]26558456
C006780bisphenol Abisphenol A affects the expression of DEPTOR mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of DEPTOR mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DEPTOR mRNA28628672
C006780bisphenol Abisphenol A affects the expression of DEPTOR mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DEPTOR mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DEPTOR mRNA28628672
D002065BuspironeBuspirone results in increased expression of DEPTOR mRNA24136188
C584509C646 compoundC646 compound results in increased expression of DEPTOR mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DEPTOR mRNA17484886|2733941
D003300CopperCopper results in decreased expression of DEPTOR mRNA17205981
D016572CyclosporineCyclosporine results in decreased expression of DEPTOR mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DEPTOR mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of DEPTOR mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DEPTOR mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DEPTOR mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of DEPTOR mRNA22733784
D002945CisplatinCisplatin results in decreased expression of DEPTOR mRNA27594783
D002945CisplatinDEPTOR protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in decreased expression of DEPTOR mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of DEPTOR mRNA19371625
C118739entinostatentinostat results in increased expression of DEPTOR mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DEPTOR mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DEPTOR mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DEPTOR mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DEPTOR mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of DEPTOR mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of DEPTOR mRNA28189721
D005485FlutamideFlutamide results in decreased expression of DEPTOR mRNA24136188|2479361
D005557FormaldehydeFormaldehyde results in decreased expression of DEPTOR mRNA27664576
D017313FenretinideFenretinide results in decreased expression of DEPTOR mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of DEPTOR mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DEPTOR mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DEPTOR mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DEPTOR mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DEPTOR mRNA28628672
D007854LeadLead affects the expression of DEPTOR mRNA28903495
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of DEPTOR mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DEPTOR mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DEPTOR mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of DEPTOR mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DEPTOR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DEPTOR mRNA"25554681
D009532NickelNickel results in decreased expression of DEPTOR mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of DEPTOR mRNA22110744
C570897NSC668394NSC668394 results in decreased expression of DEPTOR mRNA27137931
D010126OzoneOzone results in decreased expression of DEPTOR mRNA28652203
D000073878Palm OilPalm Oil results in decreased expression of DEPTOR mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of DEPTOR mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DEPTOR mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of DEPTOR mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of DEPTOR mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of DEPTOR mRNA23541542
C045950propiconazolepropiconazole results in decreased expression of DEPTOR mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of DEPTOR mRNA24780913
C059514resveratrolresveratrol results in decreased expression of DEPTOR mRNA19371625
C059514resveratrolDEPTOR protein affects the susceptibility to resveratrol20851890
C059514resveratrolresveratrol promotes the reaction [MTOR protein binds to DEPTOR protein]20851890
D012715Sesame OilSesame Oil results in increased expression of DEPTOR mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DEPTOR mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of DEPTOR mRNA25351596
D012834SilverSilver results in increased expression of DEPTOR mRNA27131904
C016104sodium bichromatesodium bichromate affects the expression of DEPTOR mRNA22110744
C016766sulforafansulforafan results in decreased expression of DEPTOR mRNA26833863
D013629TamoxifenTamoxifen affects the expression of DEPTOR mRNA17555576
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DEPTOR mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEPTOR mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DEPTOR mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of DEPTOR mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of DEPTOR mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of DEPTOR mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEPTOR mRNA19933214
D019284ThapsigarginThapsigargin results in increased expression of DEPTOR mRNA22378314
C009495titanium dioxidetitanium dioxide affects the expression of DEPTOR mRNA17656681
C009495titanium dioxidetitanium dioxide results in decreased expression of DEPTOR mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DEPTOR mRNA28111298
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DEPTOR mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of DEPTOR mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of DEPTOR mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of DEPTOR mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DEPTOR gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DEPTOR mRNA"27188386
C111237vorinostatvorinostat results in increased expression of DEPTOR mRNA26272509
D015032ZincZinc deficiency results in decreased expression of DEPTOR mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19446321  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006469negative regulation of protein kinase activity-IMP19446321  
GO:0032007negative regulation of TOR signaling-IMP19446321  
GO:0035556intracellular signal transduction-IEA-  
GO:0045792negative regulation of cell size-IMP19446321  
GO:2001236regulation of extrinsic apoptotic signaling pathway-IMP19446321  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal