Gene: BMI1

648
FLVI2/BMI1|PCGF4|RNF51|flvi-2/bmi-1
BMI1 proto-oncogene, polycomb ring finger
protein-coding
10p12.2
Ensembl:ENSG00000168283 MIM:164831 Vega:OTTHUMG00000017807 UniprotKB:P35226
NC_000010.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.872e-1 (AD)  4.590e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WAC0.893
MPP50.89
VPS26A0.889
RAD210.887
NAP1L10.886
DLG10.882
SERBP10.882
GPBP10.881
IKZF50.877
IPO70.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.656
OR4F5-0.638
HES5-0.266
PLA2G5-0.261
NXNL1-0.258
KCNK5-0.246
SLC13A5-0.24
RLBP1-0.229
PTGDR2-0.214
ARSF-0.213

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0484603-deazaneplanocin3-deazaneplanocin inhibits the reaction [Smoke analog results in increased expression of BMI1 protein]25526925
C0138134-anisidine4-anisidine results in decreased expression of BMI1 mRNA12929121
D000082AcetaminophenAcetaminophen results in decreased expression of BMI1 mRNA21420995|2223033
D001151ArsenicArsenic affects the methylation of BMI1 gene25304211
D001151ArsenicArsenic results in increased expression of BMI1 protein22843710
D001151ArsenicBMI1 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A mRNA]22843710
D001151ArsenicBMI1 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A protein]22843710
D001151ArsenicBMI1 protein results in increased susceptibility to Arsenic22843710
C006632arsenic trioxideBMI1 protein results in decreased susceptibility to arsenic trioxide24571310
D001280AtrazineAtrazine results in increased expression of BMI1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BMI1 mRNA19770486
D004958EstradiolEstradiol results in increased expression of BMI1 mRNA24424067
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMI1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMI1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BMI1 mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of BMI1 gene28505145
C518299BIX 01294BIX 01294 results in increased expression of BMI1 mRNA17289593
D020148Butyric AcidBMI1 protein results in decreased susceptibility to Butyric Acid24571310
D020148Butyric Acid"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]"24792773
D020148Butyric Acid"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]"24792773
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of BMI1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of BMI1 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of BMI1 mRNA23650126
D002994ClofibrateClofibrate affects the expression of BMI1 mRNA16081524
C018021cobaltous chloridecobaltous chloride results in decreased expression of BMI1 mRNA19320972
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of BMI1 mRNA17185465
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of BMI1 protein17185465
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMI1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMI1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BMI1 mRNA28628672
C042577diallyl trisulfidediallyl trisulfide affects the expression of BMI1 protein27129776
D002945CisplatinBMI1 inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein]21445297
D002945CisplatinBMI1 inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]21445297
D002945CisplatinBMI1 inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]21445297
D002945CisplatinBMI1 protein inhibits the reaction [Cisplatin results in increased abundance of Reactive Oxygen Species]21445297
D002945CisplatinBMI1 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]21311599
D002945CisplatinBMI1 protein inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]21311599
D002945CisplatinBMI1 protein results in decreased susceptibility to Cisplatin21311599|2144529
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of BMI1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of BMI1 mRNA27392435
D002945Cisplatin[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of BMI1 mRNA21342274
D002945Cisplatin[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of BMI1 protein21342274
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of BMI1 mRNA]27392435
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]"24792773
D004147DioxinsDioxins affects the expression of BMI1 mRNA20463971
D004317DoxorubicinDoxorubicin results in decreased expression of BMI1 protein24902966
D004317DoxorubicinQuercetin inhibits the reaction [Doxorubicin results in decreased expression of BMI1 protein]24902966
D004317DoxorubicinBMI1 protein results in decreased susceptibility to Doxorubicin24902966
D004317DoxorubicinDoxorubicin results in decreased expression of BMI1 protein24902966
D004317DoxorubicinQuercetin inhibits the reaction [Doxorubicin results in decreased expression of BMI1 protein]24902966
D019833GenisteinGenistein results in increased expression of BMI1 mRNA21048042
D005978GlutathioneBMI1 protein results in increased abundance of Glutathione21445297
D006046GoldGold results in decreased expression of BMI1 mRNA25523186
D005937Glucaric Acid"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]"24792773
D005937Glucaric Acid"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]"24792773
D006918HydroxyureaHydroxyurea results in decreased expression of BMI1 mRNA12929121
C519562imetelstatimetelstat results in decreased expression of BMI1 mRNA20824134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMI1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMI1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BMI1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of BMI1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BMI1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BMI1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BMI1 mRNA28628672
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of BMI1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of BMI1 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of BMI1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BMI1 mRNA26254443
D007649KetamineKetamine results in decreased expression of BMI1 mRNA20080153
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of BMI1 mRNA22918959
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BMI1 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BMI1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BMI1 mRNA"25620056
C000621033napabucasinnapabucasin results in decreased expression of BMI1 mRNA25605917
C000621033napabucasinnapabucasin results in decreased expression of BMI1 protein25605917
C029938nickel sulfatenickel sulfate results in decreased expression of BMI1 mRNA22714537
D009538NicotineNicotine results in increased expression of BMI1 mRNA23219715
D009538NicotineNicotine results in increased expression of BMI1 protein23219715
D009538NicotineSNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]23219715
D017239PaclitaxelPaclitaxel results in decreased expression of BMI1 mRNA12929121
C551803PCI 32765PCI 32765 results in decreased expression of BMI1 mRNA26254443
D010634PhenobarbitalPhenobarbital affects the expression of BMI1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of BMI1 mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of BMI1 mRNA21061450
D010936Plant ExtractsHOTAIR mutant form inhibits the reaction [Plant Extracts analog results in increased expression of BMI1 protein]25447409
D010936Plant ExtractsPlant Extracts analog results in increased expression of BMI1 protein25447409
D011748PyrogallolPyrogallol results in increased expression of BMI1 mRNA20362636
D011794QuercetinQuercetin inhibits the reaction [Doxorubicin results in decreased expression of BMI1 protein]24902966
D011794QuercetinQuercetin results in increased expression of BMI1 protein24902966
D011794QuercetinBMI1 protein results in increased susceptibility to Quercetin24902966
D011794QuercetinQuercetin inhibits the reaction [Doxorubicin results in decreased expression of BMI1 protein]24902966
D011794QuercetinQuercetin results in increased expression of BMI1 mRNA24902966
D011794QuercetinQuercetin results in increased expression of BMI1 protein24902966
C004532quinonequinone results in increased expression of BMI1 mRNA28986286
D017382Reactive Oxygen SpeciesBMI1 protein inhibits the reaction [Cisplatin results in increased abundance of Reactive Oxygen Species]21445297
D017382Reactive Oxygen SpeciesBMI1 protein results in decreased abundance of Reactive Oxygen Species24902966
C089730rosiglitazonerosiglitazone results in decreased expression of BMI1 mRNA19955217
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of BMI1 mRNA23806026
D012906Smoke3-deazaneplanocin inhibits the reaction [Smoke analog results in increased expression of BMI1 protein]25526925
D012906SmokeEZH2 mutant form inhibits the reaction [Smoke analog results in increased expression of BMI1 protein]25526925
D012906SmokeHOTAIR mutant form inhibits the reaction [Smoke analog results in increased expression of BMI1 protein]25447409
D012906SmokeSmoke analog results in increased expression of BMI1 protein25447409|2552692
C017947sodium arseniteEPAS1 mutant form inhibits the reaction [sodium arsenite results in increased expression of BMI1 protein]22662215
C017947sodium arsenitesodium arsenite affects the expression of BMI1 mRNA20056578
C017947sodium arsenitesodium arsenite affects the methylation of BMI1 gene28589171
C017947sodium arsenitesodium arsenite promotes the reaction [EPAS1 protein binds to BMI1 promoter]22662215
C017947sodium arsenitesodium arsenite results in increased expression of BMI1 mRNA22662215
C017947sodium arsenitesodium arsenite results in increased expression of BMI1 protein22662215
C017947sodium arsenitesodium arsenite results in increased expression of BMI1 mRNA19072884
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMI1 mRNA21570461|2468072
D013755Tetradecanoylphorbol AcetateBMI1 protein results in decreased susceptibility to Tetradecanoylphorbol Acetate24571310
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of BMI1 mRNA25613284
D014212TretinoinTretinoin results in decreased expression of BMI1 mRNA20530235
D014212TretinoinTretinoin results in increased expression of BMI1 mRNA21934132|2372400
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of BMI1 mRNA17185465
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of BMI1 protein17185465
C012589trichostatin Atrichostatin A affects the expression of BMI1 mRNA28542535
D014635Valproic AcidValproic Acid results in decreased methylation of BMI1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of BMI1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BMI1 gene25560391
D009536Niacinamide"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]"24792773
D009536Niacinamide"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]"24792773
D015032ZincZinc deficiency results in decreased expression of BMI1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15386022  16710298  17332741  19233177  19636380  19903340  
20543829  20601937  21282530  21772249  22078878  22493164  
22897849  22902369  23523425  25185265  25416956  26496610  
27705803  
GO:0008270zinc ion binding-IDA16714294  
GO:0071535RING-like zinc finger domain binding-IPI16714294  
GO:1990841promoter-specific chromatin binding-IBA21873635  
GO:1990841promoter-specific chromatin binding-IDA24623306  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP19636380  
GO:0006342chromatin silencing-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007379segment specification-TAS7715727  
GO:0010468regulation of gene expression-IMP17420273  
GO:0030097hemopoiesis-IEP15334543  
GO:0036353histone H2A-K119 monoubiquitination-IBA21873635  
GO:0036353histone H2A-K119 monoubiquitination-IMP26151332  
GO:0045814negative regulation of gene expression, epigenetic-IMP24623306  
GO:0048146positive regulation of fibroblast proliferation-IMP17420273  
GO:0051443positive regulation of ubiquitin-protein transferase activity-IDA16714294  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IDA16714294  
GO:0005634nucleus-IDA9367786  10445843  21282530  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0016604nuclear body-IDA-  
GO:0031519PcG protein complex-IDA21282530  26151332  
GO:0035102PRC1 complex-IBA21873635  
GO:0035102PRC1 complex-IDA12167701  19636380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4570464SUMOylation of RNA binding proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8953750Transcriptional Regulation by E2F6TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27212446Epigenetic silencing of miR-218 by the lncRNA CCAT1, acting via BMI1, promotes an altered cell cycle transition in the malignant transformation of HBE cells induced by cigarette smoke extract. (2016 Aug 1)Lu LToxicol Appl Pharmacol
24296751Autoantibodies as potential biomarkers for the early detection of esophageal squamous cell carcinoma. (2014 Jan)Xu YWAm J Gastroenterol