Gene: ST6GAL1

6480
SIAT1|ST6GalI|ST6N
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
protein-coding
3q27.3
Ensembl:ENSG00000073849 MIM:109675 Vega:OTTHUMG00000156500 UniprotKB:P15907
NC_000003.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.287e-1 (AD)  7.748e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYFIP10.796
CTTNBP2NL0.796
SH2B30.787
LRCH10.785
PTGS10.781
SRGAP2B0.773
GMIP0.768
SRGAP20.763
NCOA30.752
HPS30.751

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.41
OR4F5-0.394
HES5-0.355
DIAPH3-0.35
HPDL-0.348
NXNL1-0.314
ARSF-0.3
NPFFR1-0.289
SOX3-0.281
REN-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ST6GAL1 mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST6GAL1 mRNA"25510870
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ST6GAL1 mRNA"21724226
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST6GAL1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST6GAL1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST6GAL1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ST6GAL1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST6GAL1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ST6GAL1 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ST6GAL1 mRNA"19692669|2319667
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of ST6GAL1 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST6GAL1 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of ST6GAL1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST6GAL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ST6GAL1 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ST6GAL1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST6GAL1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST6GAL1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ST6GAL1 mRNA21757418
D000499AllylamineAllylamine results in increased expression of ST6GAL1 mRNA15910882
D000638AmiodaroneAmiodarone affects the expression of ST6GAL1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ST6GAL1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ST6GAL1 mRNA25339124
D001280AtrazineAtrazine results in decreased expression of ST6GAL1 mRNA22378314
D001553BenzbromaroneBenzbromarone affects the expression of ST6GAL1 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST6GAL1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST6GAL1 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of ST6GAL1 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of ST6GAL1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ST6GAL1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of ST6GAL1 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of ST6GAL1 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of ST6GAL1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of ST6GAL1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ST6GAL1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ST6GAL1 mRNA16239168
D002330CarmustineCarmustine results in increased expression of ST6GAL1 mRNA15980968
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ST6GAL1 gene20938992
D002994ClofibrateClofibrate affects the expression of ST6GAL1 mRNA19483382
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ST6GAL1 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of ST6GAL1 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of ST6GAL1 mRNA17211630
D003471CuprizoneCuprizone results in increased expression of ST6GAL1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ST6GAL1 mRNA20106945|2556210
C014347decitabinedecitabine inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of ST6GAL1 mRNA]28031460
D003907Dexamethasonedecitabine inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of ST6GAL1 mRNA]28031460
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of ST6GAL1 mRNA28031460
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased methylation of ST6GAL1 promoter28031460
D003907DexamethasoneITGB1 protein promotes the reaction [ST6GAL1 protein inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA]]28031460
D003907DexamethasoneST6GAL1 protein inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA]28031460
D002945CisplatinCisplatin results in decreased expression of ST6GAL1 mRNA27594783
D004008DiclofenacDiclofenac results in increased expression of ST6GAL1 mRNA26934552
D004026DieldrinDieldrin results in increased expression of ST6GAL1 mRNA23041725
D004041Dietary FatsDietary Fats results in decreased expression of ST6GAL1 mRNA28031460
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ST6GAL1 mRNA17602206
D004237DiuronDiuron metabolite results in increased expression of ST6GAL1 mRNA24172598
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ST6GAL1 mRNA12655037
D005001EthionineEthionine affects the expression of ST6GAL1 mRNA19483382
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ST6GAL1 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of ST6GAL1 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of ST6GAL1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ST6GAL1 gene20938992
D004397FonofosFonofos results in decreased methylation of ST6GAL1 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of ST6GAL1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of ST6GAL1 mRNA19167457
C039281furanfuran results in decreased expression of ST6GAL1 mRNA25539665
C039281furanfuran results in increased methylation of ST6GAL1 gene22079235
D005839GentamicinsGentamicins results in decreased expression of ST6GAL1 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of ST6GAL1 mRNA22061828
D005944GlucosamineGlucosamine results in increased expression of ST6GAL1 mRNA17178593
D017313FenretinideFenretinide results in increased expression of ST6GAL1 mRNA28973697
D0150561-Methyl-3-isobutylxanthinedecitabine inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of ST6GAL1 mRNA]28031460
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of ST6GAL1 mRNA28031460
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased methylation of ST6GAL1 promoter28031460
D0150561-Methyl-3-isobutylxanthineITGB1 protein promotes the reaction [ST6GAL1 protein inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA]]28031460
D0150561-Methyl-3-isobutylxanthineST6GAL1 protein inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPB mRNA]28031460
C544151jinfukangjinfukang results in increased expression of ST6GAL1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of ST6GAL1 mRNA24086573
D008095Lithocholic AcidLithocholic Acid analog results in decreased activity of ST6GAL1 protein21224350
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ST6GAL1 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ST6GAL1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ST6GAL1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ST6GAL1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ST6GAL1 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of ST6GAL1 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of ST6GAL1 mRNA24136188
D009525NiacinNiacin results in increased expression of ST6GAL1 mRNA20303128
C022838nickel chloridenickel chloride results in increased expression of ST6GAL1 mRNA17312168
C012655nimesulidenimesulide results in decreased expression of ST6GAL1 mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of ST6GAL1 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ST6GAL1 mRNA25729387
D010076OxazepamOxazepam results in increased expression of ST6GAL1 mRNA12727805
D010278ParathionParathion results in decreased methylation of ST6GAL1 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST6GAL1 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ST6GAL1 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST6GAL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ST6GAL1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of ST6GAL1 mRNA12727805|1844570
C006253pirinixic acidpirinixic acid affects the expression of ST6GAL1 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of ST6GAL1 mRNA19162173
D011441PropylthiouracilPropylthiouracil affects the expression of ST6GAL1 mRNA19483382
D011794QuercetinQuercetin results in decreased expression of ST6GAL1 mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of ST6GAL1 mRNA25572481
D012715Sesame OilSesame Oil results in increased expression of ST6GAL1 mRNA29191790
D012795SialoglycoproteinsST6GAL1 protein results in increased abundance of Sialoglycoproteins28031460
D012795Sialoglycoproteins[ST6GAL1 protein results in increased abundance of Sialoglycoproteins] which results in increased glycosylation of and results in increased activity of ITGB1 protein28031460
D012795Sialoglycoproteins[[ST6GAL1 protein results in increased abundance of Sialoglycoproteins] which results in increased glycosylation of and results in increased activity of ITGB1 protein] which results in increased phosphorylation of PTK2 protein28031460
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ST6GAL1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ST6GAL1 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ST6GAL1 mRNA19073995
D012822Silicon DioxideSilicon Dioxide results in increased expression of ST6GAL1 mRNA23221170
D012834SilverSilver results in decreased expression of ST6GAL1 mRNA27131904
D012906SmokeSmoke affects the expression of ST6GAL1 mRNA26109882
C017947sodium arsenitesodium arsenite affects the methylation of ST6GAL1 gene28589171
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ST6GAL1 mRNA21641980
D013629TamoxifenTamoxifen results in decreased expression of ST6GAL1 mRNA25123088
C012568terbufosterbufos results in decreased methylation of ST6GAL1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST6GAL1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST6GAL1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST6GAL1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST6GAL1 mRNA19692669|2172422
D013853ThioacetamideThioacetamide affects the expression of ST6GAL1 mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ST6GAL1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ST6GAL1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ST6GAL1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ST6GAL1 mRNA16604517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ST6GAL1 mRNA"26179874
C406224valdecoxibvaldecoxib results in decreased expression of ST6GAL1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of ST6GAL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ST6GAL1 mRNA29154799
D014640VancomycinVancomycin results in decreased expression of ST6GAL1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ST6GAL1 gene25560391
C111237vorinostatvorinostat results in decreased expression of ST6GAL1 mRNA27188386
D015032ZincZinc results in decreased expression of ST6GAL1 mRNA20932299
C088658zoledronic acidzoledronic acid results in increased expression of ST6GAL1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003835beta-galactoside alpha-2,6-sialyltransferase activity-IBA21873635  
GO:0003835beta-galactoside alpha-2,6-sialyltransferase activity-IDA23999306  
GO:0003835beta-galactoside alpha-2,6-sialyltransferase activity-TAS-  
GO:0005515protein binding-IPI16237761  
GO:0008373sialyltransferase activity-IDA21081508  
GO ID GO Term Qualifier Evidence PubMed
GO:0006054N-acetylneuraminate metabolic process-IDA23999306  
GO:0006959humoral immune response-TAS7786324  
GO:0016266O-glycan processing-TAS-  
GO:0018279protein N-linked glycosylation via asparagine-IDA23999306  
GO:0097503sialylation-IDA23999306  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
KEGG ID KEGG Term
hsa00510N-Glycan biosynthesis
hsa00514Other types of O-glycan biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975577N-Glycan antennae elongationTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One
27704662Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy. (2016 Dec)Nio-Kobayashi JMol Reprod Dev