Gene info: ID 64805

Gene: P2RY12

GENE ID: 64805

Description: purinergic receptor P2Y12

Gene type: protein-coding

Location: 3q25.1

dbXrefs: Ensembl:ENSG00000169313 MIM:600515 Vega:OTTHUMG00000159863 UniprotKB:Q9H244

RefSeq: NG_016019.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.689e-1 (AD) 5.627e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14191476	chr3:151058837	P2RY12	Promoter	2.300e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CX3CR1	0.926
P2RY13	0.908
SUSD3	0.871
MPEG1	0.853
SELPLG	0.84
GPR34	0.825
PLD4	0.822
BLNK	0.815
FOLR2	0.805
OLFML3	0.794

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRYBB2	-0.375
MISP	-0.321
DNASE1L2	-0.321
BGLAP	-0.305
KLK14	-0.303
TDRG1	-0.297
JSRP1	-0.296
NPIPB6	-0.294
NTSR2	-0.289
SLC35G5	-0.289

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00208	Ticlopidine	Small Molecule	55142-85-3	Approved	Target
DB00374	Treprostinil	Small Molecule	81846-19-7	Approved\|Investigational	Target
DB00758	Clopidogrel	Small Molecule	113665-84-2	Approved	Target
DB01240	Epoprostenol	Small Molecule	35121-78-9	Approved	Target
DB05553	Regrelor	Small Molecule	787548-03-2	Investigational	Target
DB06209	Prasugrel	Small Molecule	150322-43-3	Approved	Target
DB06441	Cangrelor	Small Molecule	163706-06-7	Approved	Target
DB08816	Ticagrelor	Small Molecule	274693-27-5	Approved	Target

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of P2RY12 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of P2RY12 mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of P2RY12 mRNA"	18648102
D020106	Acrylamide	Acrylamide results in decreased expression of P2RY12 mRNA	28959563
D000244	Adenosine Diphosphate	P2RY12 gene polymorphism affects the susceptibility to Adenosine Diphosphate	23849096
D000244	Adenosine Diphosphate	P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]	18404433
D000244	Adenosine Diphosphate	P2RY12 protein affects the susceptibility to Adenosine Diphosphate	11196645
D000244	Adenosine Diphosphate	Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]	11413167
D000244	Adenosine Diphosphate	P2RY12 protein results in increased susceptibility to Adenosine Diphosphate	11413167
D000244	Adenosine Diphosphate	P2RY12 protein affects the susceptibility to Adenosine Diphosphate	11196645
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of P2RY12 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of P2RY12 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of P2RY12 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of P2RY12 mRNA	19654921
D001241	Aspirin	P2RY12 affects the susceptibility to Aspirin	14597584
C006780	bisphenol A	bisphenol A results in decreased expression of P2RY12 mRNA	25181051
C074619	bivalirudin	P2RY12 affects the susceptibility to bivalirudin	14597584
C400786	BnSO(2)-D-Arg-Gly-Arg-ketothiazole	P2RY12 affects the susceptibility to BnSO(2)-D-Arg-Gly-Arg-ketothiazole	14597584
C117446	cangrelor	"[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate"	12606772
C117446	cangrelor	[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased phosphorylation of SYK protein	12606772
C117446	cangrelor	cangrelor results in decreased activity of P2RY12 protein	22273509
C117446	cangrelor	P2RY12 gene polymorphism affects the susceptibility to cangrelor	20126830
C117446	cangrelor	cangrelor binds to and results in decreased activity of P2RY12 protein	17334511
C055162	clopidogrel	clopidogrel binds to and results in decreased activity of P2RY12 protein	22129738
C055162	clopidogrel	P2RY12 gene affects the susceptibility to clopidogrel	18485500\|2003162
C055162	clopidogrel	P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]	18577829
C055162	clopidogrel	P2RY12 gene SNP affects the susceptibility to clopidogrel	15933261
C055162	clopidogrel	P2RY12 protein affects the susceptibility to clopidogrel	18404433
C055162	clopidogrel	P2RY12 protein results in increased susceptibility to clopidogrel	11413167
C435072	CT 50547	CT 50547 analog binds to and results in decreased activity of P2RY12 protein	11459636
C435072	CT 50547	CT 50547 binds to and results in decreased activity of P2RY12 protein	11459636
D004041	Dietary Fats	Dietary Fats results in increased expression of P2RY12 mRNA	25016146
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in increased expression of P2RY12 mRNA	21852083
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of P2RY12 mRNA	26924002
D004237	Diuron	Diuron results in decreased expression of P2RY12 mRNA	25152437
D004837	Epinephrine	Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]	11413167
D005419	Flavonoids	Flavonoids results in increased expression of P2RY12 mRNA	18035473
C039281	furan	furan results in increased expression of P2RY12 mRNA	27387713
C039281	furan	furan results in increased methylation of P2RY12 gene	22079235
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RY12 mRNA	25613284
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of P2RY12 mRNA	26924002
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of P2RY12 mRNA	25729387
C060974	phosphatidylinositol 3,4,5-triphosphate	"[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate"	12606772
D000068799	Prasugrel Hydrochloride	Prasugrel Hydrochloride binds to and results in decreased activity of P2RY12 protein	17681285
D000068799	Prasugrel Hydrochloride	Prasugrel Hydrochloride metabolite results in decreased activity of P2RY12 protein	22692976
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in increased expression of P2RY12 mRNA	21852083
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of P2RY12 mRNA	19073995
D012999	Soman	Soman results in increased expression of P2RY12 mRNA	19281266
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RY12 mRNA	25613284
C503700	Ticagrelor	Ticagrelor binds to and results in decreased activity of P2RY12 protein	19637098
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of P2RY12 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of P2RY12 mRNA	25729387
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of P2RY12 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of P2RY12 mRNA	23869203
C029297	vinylidene chloride	vinylidene chloride results in increased expression of P2RY12 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001609	G-protein coupled adenosine receptor activity	-	IEA	-
GO:0001621	ADP receptor activity	-	IDA	11104774
GO:0001621	ADP receptor activity	-	IMP	12578987
GO:0005085	guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0045028	G-protein coupled purinergic nucleotide receptor activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001973	adenosine receptor signaling pathway	-	IEA	-
GO:0006930	substrate-dependent cell migration, cell extension	-	ISS	-
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	IDA	11104774
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	-	IMP	12578987
GO:0007202	activation of phospholipase C activity	-	TAS	20091784
GO:0007599	hemostasis	-	NAS	11196645
GO:0008347	glial cell migration	-	IEA	-
GO:0010700	negative regulation of norepinephrine secretion	-	IEA	-
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	-	IEA	-
GO:0043270	positive regulation of ion transport	-	IEA	-
GO:0043491	protein kinase B signaling	-	IEA	-
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	-	TAS	20091784
GO:0045596	negative regulation of cell differentiation	-	IEA	-
GO:0051924	regulation of calcium ion transport	-	IEA	-
GO:0070527	platelet aggregation	-	IMP	12578987
GO:0070588	calcium ion transmembrane transport	-	IEA	-
GO:0071318	cellular response to ATP	-	ISS	-
GO:0071805	potassium ion transmembrane transport	-	IEA	-
GO:1904139	regulation of microglial cell migration	-	ISS	-
GO:1904141	positive regulation of microglial cell migration	-	TAS	20091784

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IEA	-
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005901	caveola	-	IEA	-
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0009925	basal plasma membrane	-	IEA	-
GO:0009986	cell surface	-	HDA	23382103
GO:0031224	intrinsic component of membrane	-	IDA	12578987

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	TAS
R-HSA-392518	Signal amplification	TAS
R-HSA-417957	P2Y receptors	TAS
R-HSA-418038	Nucleotide-like (purinergic) receptors	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17803810	Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease. (2007 Sep 5)	Cavallari U	BMC Med Genet
17707382	Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism. (2008 Apr)	Zee RY	Atherosclerosis
28070995	Haplotype of platelet receptor P2RY12 gene is associated with residual clopidogrel on-treatment platelet reactivity. (2017 Jan.)	Nie XY	J Zhejiang Univ Sci B