Gene: P2RY12

64805
ADPG-R|BDPLT8|HORK3|P2T(AC)|P2Y(12)R|P2Y(AC)|P2Y(ADP)|P2Y(cyc)|P2Y12|SP1999
purinergic receptor P2Y12
protein-coding
3q25.1
Ensembl:ENSG00000169313 MIM:600515 Vega:OTTHUMG00000159863 UniprotKB:Q9H244
NG_016019.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.689e-1 (AD)  5.627e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14191476chr3:151058837P2RY12Promoter2.300e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CX3CR10.926
P2RY130.908
SUSD30.871
MPEG10.853
SELPLG0.84
GPR340.825
PLD40.822
BLNK0.815
FOLR20.805
OLFML30.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBB2-0.375
MISP-0.321
DNASE1L2-0.321
BGLAP-0.305
KLK14-0.303
TDRG1-0.297
JSRP1-0.296
NPIPB6-0.294
NTSR2-0.289
SLC35G5-0.289

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00208TiclopidineSmall Molecule55142-85-3ApprovedTarget
DB00374TreprostinilSmall Molecule81846-19-7Approved|InvestigationalTarget
DB00758ClopidogrelSmall Molecule113665-84-2ApprovedTarget
DB01240EpoprostenolSmall Molecule35121-78-9ApprovedTarget
DB05553RegrelorSmall Molecule787548-03-2InvestigationalTarget
DB06209PrasugrelSmall Molecule150322-43-3ApprovedTarget
DB06441CangrelorSmall Molecule163706-06-7ApprovedTarget
DB08816TicagrelorSmall Molecule274693-27-5ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of P2RY12 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of P2RY12 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of P2RY12 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of P2RY12 mRNA28959563
D000244Adenosine DiphosphateP2RY12 gene polymorphism affects the susceptibility to Adenosine Diphosphate23849096
D000244Adenosine DiphosphateP2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]18404433
D000244Adenosine DiphosphateP2RY12 protein affects the susceptibility to Adenosine Diphosphate11196645
D000244Adenosine DiphosphateEpinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]11413167
D000244Adenosine DiphosphateP2RY12 protein results in increased susceptibility to Adenosine Diphosphate11413167
D000244Adenosine DiphosphateP2RY12 protein affects the susceptibility to Adenosine Diphosphate11196645
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of P2RY12 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of P2RY12 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of P2RY12 mRNA24449571
D001151ArsenicArsenic results in decreased expression of P2RY12 mRNA19654921
D001241AspirinP2RY12 affects the susceptibility to Aspirin14597584
C006780bisphenol Abisphenol A results in decreased expression of P2RY12 mRNA25181051
C074619bivalirudinP2RY12 affects the susceptibility to bivalirudin14597584
C400786BnSO(2)-D-Arg-Gly-Arg-ketothiazoleP2RY12 affects the susceptibility to BnSO(2)-D-Arg-Gly-Arg-ketothiazole14597584
C117446cangrelor"[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate"12606772
C117446cangrelor[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased phosphorylation of SYK protein12606772
C117446cangrelorcangrelor results in decreased activity of P2RY12 protein22273509
C117446cangrelorP2RY12 gene polymorphism affects the susceptibility to cangrelor20126830
C117446cangrelorcangrelor binds to and results in decreased activity of P2RY12 protein17334511
C055162clopidogrelclopidogrel binds to and results in decreased activity of P2RY12 protein22129738
C055162clopidogrelP2RY12 gene affects the susceptibility to clopidogrel18485500|2003162
C055162clopidogrelP2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]18577829
C055162clopidogrelP2RY12 gene SNP affects the susceptibility to clopidogrel15933261
C055162clopidogrelP2RY12 protein affects the susceptibility to clopidogrel18404433
C055162clopidogrelP2RY12 protein results in increased susceptibility to clopidogrel11413167
C435072CT 50547CT 50547 analog binds to and results in decreased activity of P2RY12 protein11459636
C435072CT 50547CT 50547 binds to and results in decreased activity of P2RY12 protein11459636
D004041Dietary FatsDietary Fats results in increased expression of P2RY12 mRNA25016146
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of P2RY12 mRNA21852083
C024629dimethyl phthalatedimethyl phthalate affects the expression of P2RY12 mRNA26924002
D004237DiuronDiuron results in decreased expression of P2RY12 mRNA25152437
D004837EpinephrineEpinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]11413167
D005419FlavonoidsFlavonoids results in increased expression of P2RY12 mRNA18035473
C039281furanfuran results in increased expression of P2RY12 mRNA27387713
C039281furanfuran results in increased methylation of P2RY12 gene22079235
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RY12 mRNA25613284
C517284monomethyl phthalatemonomethyl phthalate affects the expression of P2RY12 mRNA26924002
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of P2RY12 mRNA25729387
C060974phosphatidylinositol 3,4,5-triphosphate"[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate"12606772
D000068799Prasugrel HydrochloridePrasugrel Hydrochloride binds to and results in decreased activity of P2RY12 protein17681285
D000068799Prasugrel HydrochloridePrasugrel Hydrochloride metabolite results in decreased activity of P2RY12 protein22692976
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of P2RY12 mRNA21852083
D012822Silicon DioxideSilicon Dioxide results in decreased expression of P2RY12 mRNA19073995
D012999SomanSoman results in increased expression of P2RY12 mRNA19281266
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RY12 mRNA25613284
C503700TicagrelorTicagrelor binds to and results in decreased activity of P2RY12 protein19637098
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of P2RY12 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of P2RY12 mRNA25729387
D001335Vehicle EmissionsVehicle Emissions affects the methylation of P2RY12 gene25560391
C025643vinclozolinvinclozolin results in increased expression of P2RY12 mRNA23869203
C029297vinylidene chloridevinylidene chloride results in increased expression of P2RY12 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001609G-protein coupled adenosine receptor activity-IEA-  
GO:0001621ADP receptor activity-IDA11104774  
GO:0001621ADP receptor activity-IMP12578987  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0045028G-protein coupled purinergic nucleotide receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001973adenosine receptor signaling pathway-IEA-  
GO:0006930substrate-dependent cell migration, cell extension-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IDA11104774  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IMP12578987  
GO:0007202activation of phospholipase C activity-TAS20091784  
GO:0007599hemostasis-NAS11196645  
GO:0008347glial cell migration-IEA-  
GO:0010700negative regulation of norepinephrine secretion-IEA-  
GO:0035589G-protein coupled purinergic nucleotide receptor signaling pathway-IEA-  
GO:0043270positive regulation of ion transport-IEA-  
GO:0043491protein kinase B signaling-IEA-  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-TAS20091784  
GO:0045596negative regulation of cell differentiation-IEA-  
GO:0051924regulation of calcium ion transport-IEA-  
GO:0070527platelet aggregation-IMP12578987  
GO:0070588calcium ion transmembrane transport-IEA-  
GO:0071318cellular response to ATP-ISS-  
GO:0071805potassium ion transmembrane transport-IEA-  
GO:1904139regulation of microglial cell migration-ISS-  
GO:1904141positive regulation of microglial cell migration-TAS20091784  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005901caveola-IEA-  
GO:0009897external side of plasma membrane-IEA-  
GO:0009925basal plasma membrane-IEA-  
GO:0009986cell surface-HDA23382103  
GO:0031224intrinsic component of membrane-IDA12578987  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392170ADP signalling through P2Y purinoceptor 12TAS
R-HSA-392518Signal amplificationTAS
R-HSA-417957P2Y receptorsTAS
R-HSA-418038Nucleotide-like (purinergic) receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17803810Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease. (2007 Sep 5)Cavallari UBMC Med Genet
17707382Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism. (2008 Apr)Zee RYAtherosclerosis
28070995Haplotype of platelet receptor P2RY12 gene is associated with residual clopidogrel on-treatment platelet reactivity. (2017 Jan.)Nie XYJ Zhejiang Univ Sci B