Gene: CYP3A43

64816
-
cytochrome P450 family 3 subfamily A member 43
protein-coding
7q22.1
Ensembl:ENSG00000021461 MIM:606534 Vega:OTTHUMG00000156498 UniprotKB:Q9HB55
NG_007935.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.627e-1 (AD)  2.929e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL28A10.598
MST10.578
CUBN0.577
PHKA20.56
AMY2B0.558
SLC46A30.549
TNNI3K0.533
CAD0.531
SEC31B0.528
AGBL20.528

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAC-0.294
TMSB15A-0.285
CRH-0.267
CHAC2-0.243
LYPD1-0.241
HIST1H4D-0.235
TSPAN16-0.228
EVA1A-0.226
SPRED3-0.224
GGN-0.223

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11994DiacereinSmall Molecule13739-02-1Approved|InvestigationalTarget
DB00503RitonavirSmall Molecule155213-67-5Approved|InvestigationalEnzyme
DB00593EthosuximideSmall Molecule77-67-8ApprovedEnzyme
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalEnzyme
DB00780PhenelzineSmall Molecule51-71-8ApprovedEnzyme
DB00842OxazepamSmall Molecule604-75-1ApprovedEnzyme
DB00943ZalcitabineSmall Molecule7481-89-2Approved|InvestigationalEnzyme
DB01045RifampicinSmall Molecule13292-46-1ApprovedEnzyme
DB01058PraziquantelSmall Molecule55268-74-1Approved|InvestigationalEnzyme
DB01201RifapentineSmall Molecule61379-65-5Approved|InvestigationalEnzyme
DB01234DexamethasoneSmall Molecule50-02-2Approved|InvestigationalEnzyme
DB06412OxymetholoneSmall Molecule434-07-1Approved|IllicitEnzyme
DB06595MidostaurinSmall Molecule120685-11-2Approved|InvestigationalEnzyme
DB09048NetupitantSmall Molecule290297-26-6Approved|InvestigationalEnzyme
DB09054IdelalisibSmall Molecule870281-82-6ApprovedEnzyme
DB09065CobicistatSmall Molecule1004316-88-4ApprovedEnzyme
DB09102DaclatasvirSmall Molecule1009119-64-5Approved|InvestigationalEnzyme
DB11574ElbasvirSmall Molecule1370468-36-2ApprovedEnzyme
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalEnzyme
DB12483CopanlisibSmall Molecule1032568-63-0Approved|InvestigationalEnzyme
DB13179TroleandomycinSmall Molecule2751-09-9ApprovedEnzyme
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedEnzyme
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedEnzyme
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalEnzyme
DB05239CobimetinibSmall Molecule934660-93-2Approved|InvestigationalEnzyme
DB06290SimeprevirSmall Molecule923604-59-5ApprovedEnzyme
DB08930DolutegravirSmall Molecule1051375-16-6ApprovedEnzyme
DB09229AranidipineSmall Molecule86780-90-7Approved|InvestigationalEnzyme
DB09232CilnidipineSmall Molecule132203-70-4Approved|InvestigationalEnzyme
DB11605MyrrhSmall Molecule9000-45-7ApprovedEnzyme
DB11691NaldemedineSmall Molecule916072-89-4Approved|InvestigationalEnzyme
DB13174RheinSmall Molecule478-43-3ExperimentalEnzyme
DB13878PibrentasvirSmall Molecule1353900-92-1Approved|InvestigationalEnzyme
DB13879GlecaprevirSmall Molecule1365970-03-1Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CYP3A43 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP3A43 protein]26598702
D000082AcetaminophenAcetaminophen results in increased expression of CYP3A43 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYP3A43 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CYP3A43 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYP3A43 mRNA21632981
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP3A43 protein]26598702
C006632arsenic trioxidearsenic trioxide results in increased expression of CYP3A43 mRNA15761015
D019207beta Carotenebeta Carotene results in increased expression of CYP3A43 mRNA17034753
C006780bisphenol Abisphenol A results in decreased expression of CYP3A43 mRNA25181051
D002220CarbamazepineCarbamazepine results in increased expression of CYP3A43 mRNA17112801
D016572CyclosporineCyclosporine results in decreased expression of CYP3A43 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in decreased expression of CYP3A43 mRNA23726867
D003671DEETDEET results in increased expression of CYP3A43 mRNA27091632
D003671DEET[fipronil co-treated with DEET] results in increased expression of CYP3A43 mRNA27091632
C082360fipronil[fipronil co-treated with DEET] results in increased expression of CYP3A43 mRNA27091632
C082360fipronilfipronil results in increased expression of CYP3A43 mRNA27091632
C464660obeticholic acidobeticholic acid results in decreased expression of CYP3A43 mRNA27939613
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A43 mRNA19710929
C009237senecioninesenecionine results in increased expression of CYP3A43 mRNA26100227
D013739TestosteroneCYP3A43 protein affects the metabolism of Testosterone15548719
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYP3A43 mRNA22298810
C057693troglitazonetroglitazone results in increased expression of CYP3A43 mRNA25572481
D014520UrethaneUrethane results in decreased expression of CYP3A43 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-ISS-  
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0020037heme binding-IEA-  
GO:0070330aromatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa00591Linoleic acid metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-211981XenobioticsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15698577Regulation of CYP3A genes in the human respiratory tract. (2005 Jan 15)Raunio HChem Biol Interact
23532004Relationship of early-onset baldness to prostate cancer in African-American men. (2013 Apr)Zeigler-Johnson CCancer Epidemiol Biomarkers Prev
15894682CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians. (2005 May)Stone ACancer Epidemiol Biomarkers Prev