Gene: ST3GAL4

6484
CGS23|NANTA3|SAT3|SIAT4|SIAT4C|ST-4|ST3GalA.2|ST3GalIV|STZ|gal-NAc6S
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
protein-coding
11q24.2
Ensembl:ENSG00000110080 MIM:104240 Vega:OTTHUMG00000165830 UniprotKB:Q11206
NG_053025.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.311e-1 (AD)  2.813e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRHPR0.857
TPRN0.829
SIRT20.827
MRPL430.823
IPO130.821
FAM3A0.821
TMEM420.82
NDUFS70.814
MAP6D10.813
CADM40.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.631
OR4F29-0.6
DPPA4-0.409
FER1L6-0.393
UPK1B-0.384
FCER2-0.382
ABCA13-0.378
ARHGEF35-0.377
C8orf74-0.376
C2orf83-0.371

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ST3GAL4 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ST3GAL4 mRNA"23962555
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ST3GAL4 mRNA"19114083
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of ST3GAL4 mRNA21983209
D000082AcetaminophenAcetaminophen affects the expression of ST3GAL4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ST3GAL4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST3GAL4 mRNA19770486
C015001arsenitearsenite results in decreased methylation of ST3GAL4 promoter23974009
C547126AZM551248AZM551248 results in increased expression of ST3GAL4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST3GAL4 mRNA19770486
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ST3GAL4 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ST3GAL4 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ST3GAL4 mRNA17484886
D016572CyclosporineCyclosporine results in increased expression of ST3GAL4 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of ST3GAL4 mRNA19770486
D013759DronabinolDronabinol results in decreased expression of ST3GAL4 mRNA16616335
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ST3GAL4 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of ST3GAL4 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ST3GAL4 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ST3GAL4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ST3GAL4 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ST3GAL4 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of ST3GAL4 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ST3GAL4 mRNA19245819
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ST3GAL4 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ST3GAL4 mRNA]17854601
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ST3GAL4 mRNA19041683
D002117CalcitriolCalcitriol results in decreased expression of ST3GAL4 mRNA26485663
D011345FenofibrateFenofibrate results in decreased expression of ST3GAL4 mRNA11798191
C082360fipronilfipronil results in increased expression of ST3GAL4 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of ST3GAL4 mRNA24136188
D005897GlafenineGlafenine results in increased expression of ST3GAL4 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of ST3GAL4 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ST3GAL4 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST3GAL4 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ST3GAL4 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ST3GAL4 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ST3GAL4 mRNA27392435
D007854LeadLead affects the expression of ST3GAL4 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ST3GAL4 mRNA25613284
D008095Lithocholic AcidLithocholic Acid results in increased phosphorylation of ST3GAL4 protein21224350
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ST3GAL4 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ST3GAL4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ST3GAL4 mRNA"25620056
C029938nickel sulfatenickel sulfate results in increased expression of ST3GAL4 mRNA22714537
C572573N-nitroso-tris-chloroethylureaN-nitroso-tris-chloroethylurea results in increased expression of ST3GAL4 mRNA27935865
D000073878Palm OilPalm Oil results in decreased expression of ST3GAL4 mRNA18042831
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ST3GAL4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ST3GAL4 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ST3GAL4 mRNA19270015
D010656PhenylephrinePhenylephrine results in increased expression of ST3GAL4 mRNA18158353
D010795Phthalic AcidsPhthalic Acids results in increased expression of ST3GAL4 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of ST3GAL4 mRNA11798191|1742611
D012906SmokeSmoke affects the expression of ST3GAL4 mRNA23693141
C056684soyasaponin Isoyasaponin I results in decreased expression of ST3GAL4 mRNA15661230
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST3GAL4 mRNA18372398|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST3GAL4 mRNA22298810
D013752TetracyclineTetracycline results in increased expression of ST3GAL4 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST3GAL4 mRNA25613284
D013893ThiramThiram results in decreased expression of ST3GAL4 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ST3GAL4 mRNA28065790
D014212TretinoinTretinoin results in increased expression of ST3GAL4 mRNA20530235
D014212TretinoinTretinoin results in increased expression of ST3GAL4 mRNA23830798
D014415TunicamycinTunicamycin results in increased expression of ST3GAL4 mRNA17127020
D014635Valproic AcidValproic Acid results in increased expression of ST3GAL4 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ST3GAL4 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of ST3GAL4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-IBA21873635  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-IDA8288606  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-TAS-  
GO:0047288monosialoganglioside sialyltransferase activity-IBA21873635  
GO:0047288monosialoganglioside sialyltransferase activity-IDA8288606  
GO ID GO Term Qualifier Evidence PubMed
GO:0006486protein glycosylation-IDA8288606  
GO:0009101glycoprotein biosynthetic process-IDA8288606  
GO:0009247glycolipid biosynthetic process-IDA8288606  
GO:0009312oligosaccharide biosynthetic process-IDA8288606  
GO:0016266O-glycan processing-TAS-  
GO:0018146keratan sulfate biosynthetic process-TAS-  
GO:0030259lipid glycosylation-IDA8288606  
GO:0050890cognition-IMP23227193  
GO:0097503sialylation-IDA8288606  
GO:1990743protein sialylation-IDA8288606  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638074Keratan sulfate/keratin metabolismTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-2022854Keratan sulfate biosynthesisTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975577N-Glycan antennae elongationTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27584569Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity. (2016)Song JPLoS One