Gene: METTL4

64863
HsT661
methyltransferase like 4
protein-coding
18p11.32
Ensembl:ENSG00000101574 Vega:OTTHUMG00000131482 UniprotKB:Q8N3J2
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.038e-1 (AD)  6.749e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2644171chr18:2540199 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INTS80.85
CGGBP10.831
C5orf240.822
PCMTD20.822
CREB10.821
SMARCAD10.82
INTS70.813
RAB2B0.813
CRNKL10.811
YIPF40.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.518
OR4F29-0.479
ENDOU-0.282
S100A14-0.238
PLA2G3-0.232
FOXE3-0.229
NXNL1-0.221
BANF2-0.218
ZNF705D-0.211
C6orf223-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of METTL4 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of METTL4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of METTL4 mRNA26079696
D016572CyclosporineCyclosporine results in decreased expression of METTL4 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of METTL4 mRNA20106945
C000944dicrotophosdicrotophos results in decreased expression of METTL4 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of METTL4 mRNA22079256
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of METTL4 mRNA24796395
C008261lead acetatelead acetate results in decreased expression of METTL4 mRNA22613225
C045463leflunomideleflunomide results in decreased expression of METTL4 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of METTL4 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of METTL4 mRNA"25554681
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of METTL4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of METTL4 mRNA22079256
D012969Sodium FluorideSodium Fluoride results in decreased expression of METTL4 mRNA27862939
C004648testosterone enanthatetestosterone enanthate affects the expression of METTL4 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of METTL4 mRNA21570461
D014635Valproic AcidValproic Acid results in decreased methylation of METTL4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of METTL4 gene25560391
D015032ZincZinc deficiency results in decreased expression of METTL4 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0008168methyltransferase activity-IBA21873635  
GO:0009007site-specific DNA-methyltransferase (adenine-specific) activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0032775DNA methylation on adenine-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal