Gene: C12orf43

64897
Custos
chromosome 12 open reading frame 43
protein-coding
12q24.31
Ensembl:ENSG00000157895 Vega:OTTHUMG00000169150 UniprotKB:Q96C57
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
4.932e-2 (AD)  2.828e-1 (ND)   (Frontal_Cortex)
2.049e-1 (AD)  1.701e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3751151chr12:121004396 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOMM40L0.96
NDRG30.955
MOAP10.952
AP3M20.952
MAPK100.951
KIFAP30.95
ATP6V1C10.95
DCAF60.949
STRIP10.949
AMIGO10.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.535
OR4F29-0.5
CSAG1-0.483
HEY2-0.473
RAI14-0.47
CNN2-0.467
WWTR1-0.46
REST-0.454
YES1-0.453
MTRNR2L6-0.453

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in decreased expression of C12ORF43 mRNA22378314
C006780bisphenol Abisphenol A results in increased expression of C12ORF43 mRNA25181051
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of C12ORF43 protein23301498
D007854LeadLead affects the splicing of C12ORF43 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of C12ORF43 mRNA28988120
D014501UraniumUranium affects the expression of C12ORF43 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of C12ORF43 mRNA15672453

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21044950  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27263109A Single-Nucleotide Polymorphism in C12orf43 Region is Associated with the Risk of Coronary Artery Disease in a Pakistani Cohort. (2016 Oct)Shahzadi SBiochem Genet