Gene: BMP1

649
OI13|PCOLC|PCP|PCP2|TLD
bone morphogenetic protein 1
protein-coding
8p21.3
Ensembl:ENSG00000168487 MIM:112264 Vega:OTTHUMG00000097761 UniprotKB:P13497
NG_029659.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.473e-1 (AD)  4.620e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TYK20.828
TTC7A0.81
TCF30.8
HDAC70.794
RGL20.782
DOT1L0.779
SLC26A60.774
ARHGEF10.774
DMPK0.772
RNPEPL10.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.431
OR4F29-0.409
PPP1R17-0.256
CRH-0.245
SLC5A1-0.234
HAPLN1-0.213
FSTL5-0.211
SMIM18-0.208
MYL1-0.206
COL25A1-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of BMP1 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of BMP1 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BMP1 mRNA"27291303
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of BMP1 mRNA"20638727
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of BMP1 mRNA12419474
D000082AcetaminophenAcetaminophen results in increased expression of BMP1 mRNA22230336
D000537Aluminum OxideAluminum Oxide results in increased expression of BMP1 mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BMP1 mRNA16483693
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP1 mRNA15994055
D016589AstemizoleAstemizole results in decreased expression of BMP1 mRNA20221588
C547126AZM551248AZM551248 results in increased expression of BMP1 mRNA22323515
D001414BacitracinBacitracin results in increased expression of BMP1 mRNA18289764
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BMP1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of BMP1 promoter28476633
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BMP1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of BMP1 mRNA19484750
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP1 mRNA15994055
C006780bisphenol Abisphenol A affects the expression of BMP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of BMP1 gene28505145
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of BMP1 mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of BMP1 mRNA12419474
C018475butyraldehydebutyraldehyde results in decreased expression of BMP1 mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in decreased expression of BMP1 mRNA17720352
D002737ChloropreneChloroprene results in increased expression of BMP1 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of BMP1 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of BMP1 mRNA22300585
D002995Clofibric AcidClofibric Acid affects the expression of BMP1 mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BMP1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of BMP1 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of BMP1 mRNA15467011
D003314Corn OilCorn Oil affects the expression of BMP1 mRNA16360708
D016572CyclosporineCyclosporine results in increased expression of BMP1 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of BMP1 mRNA23640034
C014347decitabinedecitabine results in increased expression of BMP1 mRNA27915011
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased methylation of BMP1 promoter"28476633
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BMP1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of BMP1 mRNA18289764
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BMP1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of BMP1 mRNA18457598|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BMP1 mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of BMP1 mRNA20360939
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BMP1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BMP1 mRNA17942748
D005027Ethylene OxideEthylene Oxide results in decreased activity of BMP1 protein15224167
C082360fipronilfipronil results in decreased expression of BMP1 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of BMP1 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of BMP1 mRNA18289764
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of BMP1 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of BMP1 mRNA28973697
D008727MethotrexateMethotrexate results in increased expression of BMP1 mRNA21678067
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BMP1 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BMP1 mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of BMP1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BMP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BMP1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of BMP1 mRNA24136188
D009532NickelNickel results in increased expression of BMP1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of BMP1 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of BMP1 mRNA24136188
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of BMP1 mRNA15878706
D010081OxazoloneOxazolone results in increased expression of BMP1 mRNA11379042
D010672PhenytoinPhenytoin results in decreased expression of BMP1 mRNA14741686
C006253pirinixic acidpirinixic acid results in increased expression of BMP1 mRNA18301758
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BMP1 mRNA22714537
C045950propiconazolepropiconazole results in decreased expression of BMP1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of BMP1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of BMP1 mRNA15309432
C078903seocalcitolseocalcitol results in increased expression of BMP1 mRNA12040012
D019821SimvastatinSimvastatin results in increased expression of BMP1 mRNA12963647
D012999SomanSoman results in increased expression of BMP1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BMP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BMP1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BMP1 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of BMP1 mRNA28065790
D014212TretinoinTretinoin results in increased expression of BMP1 mRNA16604517
D014415TunicamycinTunicamycin results in decreased expression of BMP1 mRNA17127020
C406224valdecoxibvaldecoxib results in decreased expression of BMP1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of BMP1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of BMP1 gene29154799
D014640VancomycinVancomycin results in increased expression of BMP1 mRNA18289764
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BMP1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of BMP1 mRNA26682919
D002762CholecalciferolCholecalciferol results in increased expression of BMP1 mRNA17170073
C088658zoledronic acidzoledronic acid results in increased expression of BMP1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005125cytokine activity-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI19429706  20043912  20979576  23829672  25543063  
GO:0008083growth factor activity-IEA-  
GO:0008233peptidase activity-IDA12393877  16824737  
GO:0008237metallopeptidase activity-NAS7798260  
GO:0008270zinc ion binding-IEA-  
GO:0042802identical protein binding-IPI19429706  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-NAS7798260  
GO:0001502cartilage condensation-TAS3201241  
GO:0001503ossification-IEA-  
GO:0006508proteolysis-IDA16824737  
GO:0007275multicellular organism development-TAS7798260  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030154cell differentiation-IEA-  
GO:0034380high-density lipoprotein particle assembly-TAS-  
GO:0061036positive regulation of cartilage development-IDA3201241  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0031982vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-2214320Anchoring fibril formationTAS
R-HSA-2243919Crosslinking of collagen fibrilsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8963896HDL assemblyTAS
R-HSA-8963898Plasma lipoprotein assemblyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26072521A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival. (2015 Sep)Sharafeldin NJ Natl Cancer Inst