Gene: AGXT2

64902
AGT2|BAIBA|DAIBAT
alanine--glyoxylate aminotransferase 2
protein-coding
5p13.2
Ensembl:ENSG00000113492 MIM:612471 Vega:OTTHUMG00000090788 UniprotKB:Q9BYV1
NC_000005.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.139e-2 (AD)  5.220e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs40200chr5:35045640 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAMEF40.742
TAAR20.737
OR5H150.725
GACAT10.725
OR4D60.722
IL22RA20.721
POM121L120.72
OR10K20.72
OR5T20.717
KRTAP6-20.717

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUT9-0.257
TBC1D3F-0.25
TMEM221-0.248
C16orf95-0.246
CKMT1B-0.244
KCNJ3-0.24
PLA2G6-0.24
RNFT2-0.234
EFNA5-0.231
PCDH9-0.23

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of AGXT2 mRNA20566314
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AGXT2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AGXT2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AGXT2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AGXT2 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AGXT2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AGXT2 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AGXT2 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of AGXT2 mRNA21420995|2906747
D020106AcrylamideAcrylamide results in decreased expression of AGXT2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AGXT2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AGXT2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AGXT2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AGXT2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGXT2 mRNA21871943
D004958EstradiolEstradiol results in decreased expression of AGXT2 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of AGXT2 mRNA25181051
D002104CadmiumCadmium results in increased expression of AGXT2 mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AGXT2 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AGXT2 mRNA17327699
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AGXT2 mRNA27339419
D002995Clofibric AcidClofibric Acid affects the expression of AGXT2 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of AGXT2 mRNA24386269
D003300CopperCopper results in decreased expression of AGXT2 mRNA18522721
D003300CopperCopper results in decreased expression of AGXT2 mRNA22465980
D016572CyclosporineCyclosporine results in decreased expression of AGXT2 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of AGXT2 mRNA19770486
D004026DieldrinDieldrin results in increased expression of AGXT2 mRNA28385952
D004221Disulfiram[Ethanol co-treated with Disulfiram] results in decreased activity of AGXT2 protein9591243
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AGXT2 mRNA26159488
D000431Ethanol[Ethanol co-treated with Disulfiram] results in decreased activity of AGXT2 protein9591243
C024565ethylene dichlorideethylene dichloride results in decreased expression of AGXT2 mRNA28189721
D011345FenofibrateFenofibrate results in decreased expression of AGXT2 mRNA25572481
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of AGXT2 mRNA20566314
D017313FenretinideFenretinide results in increased expression of AGXT2 mRNA28973697
C051752nefazodonenefazodone results in decreased expression of AGXT2 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of AGXT2 mRNA24136188
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AGXT2 mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of AGXT2 mRNA17164430
C015586propiverinepropiverine binds to AGXT2 protein29273565
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of AGXT2 protein19264907
C089730rosiglitazonerosiglitazone results in decreased expression of AGXT2 mRNA25572481
C089730rosiglitazonerosiglitazone results in decreased expression of AGXT2 mRNA21515302
C016104sodium bichromatesodium bichromate results in decreased expression of AGXT2 mRNA25993096
D013311StreptozocinStreptozocin results in decreased expression of AGXT2 protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of AGXT2 protein]19634143
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AGXT2 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGXT2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AGXT2 mRNA19770486
D013853ThioacetamideThioacetamide results in decreased expression of AGXT2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AGXT2 protein22609517
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of AGXT2 protein]19634143
C057693troglitazonetroglitazone results in decreased expression of AGXT2 mRNA25572481
C057693troglitazonetroglitazone results in decreased expression of AGXT2 mRNA21515302
D014635Valproic AcidValproic Acid results in decreased expression of AGXT2 mRNA29154799
D014640VancomycinVancomycin results in increased expression of AGXT2 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008453alanine-glyoxylate transaminase activity-IDA20018850  24586340  
GO:0008453alanine-glyoxylate transaminase activity-TAS-  
GO:0047305(R)-3-amino-2-methylpropionate-pyruvate transaminase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009436glyoxylate catabolic process-IBA21873635  
GO:0009436glyoxylate catabolic process-IDA20018850  
GO:0019265glycine biosynthetic process, by transamination of glyoxylate-IDA20018850  
GO:0019481L-alanine catabolic process, by transamination-IBA21873635  
GO:0019481L-alanine catabolic process, by transamination-IDA20018850  
GO:0045429positive regulation of nitric oxide biosynthetic process-IBA21873635  
GO:0045429positive regulation of nitric oxide biosynthetic process-IDA20018850  
GO:0046487glyoxylate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA20018850  24586340  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00260Glycine, serine and threonine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-15869Metabolism of nucleotidesIEA
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-73621Pyrimidine catabolismIEA
R-HSA-8956319Nucleobase catabolismIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28942034AGXT2 rs37369 polymorphism predicts the renal function in patients with chronic heart failure. (2017 Dec 30)Hu XLGene