Gene: STIL

6491
MCPH7|SIL
STIL, centriolar assembly protein
protein-coding
1p33
Ensembl:ENSG00000123473 MIM:181590 Vega:OTTHUMG00000007851 UniprotKB:Q15468
NG_012126.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.008e-1 (AD)  8.049e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SETDB20.828
NAA250.826
CCNT20.822
ATG2B0.82
CHD60.818
MYSM10.816
DDI20.815
RPS6KB10.814
XPO40.812
TMEM161B0.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.357
OR4F16-0.33
OR4F29-0.324
AQP5-0.322
MDFI-0.318
KLRB1-0.316
S100A1-0.315
NKX6-1-0.313
MTRNR2L9-0.308
BCL7C-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of STIL mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STIL mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of STIL mRNA"25614096
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of STIL mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STIL mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STIL mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STIL mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STIL mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of STIL mRNA25088246
D000082AcetaminophenAcetaminophen results in increased expression of STIL mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of STIL protein20106945
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of STIL mRNA"22863853
D001379AzathioprineAzathioprine results in decreased expression of STIL mRNA22623647
C547126AZM551248AZM551248 results in increased expression of STIL mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STIL mRNA21802500
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STIL mRNA"20382639
D004958EstradiolEstradiol results in increased expression of STIL mRNA19167446|2010694
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of STIL mRNA]25210133
D004958EstradiolEstradiol results in increased expression of STIL mRNA25210133
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of STIL mRNA26496021
C006780bisphenol Abisphenol A affects the expression of STIL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of STIL mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of STIL mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of STIL mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of STIL mRNA24763279
D002737ChloropreneChloroprene results in increased expression of STIL mRNA23125180
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of STIL mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of STIL mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of STIL mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of STIL mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of STIL mRNA20579391
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of STIL mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of STIL mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of STIL mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of STIL mRNA21592394
D004147DioxinsDioxins affects the expression of STIL mRNA20463971
D005557FormaldehydeFormaldehyde results in decreased expression of STIL mRNA20655997
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of STIL mRNA24763279
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STIL mRNA24796395
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STIL mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STIL mRNA23649840
D009151Mustard GasMustard Gas results in decreased expression of STIL mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of STIL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of STIL mRNA"25554681
D010100OxygenOxygen deficiency results in decreased expression of STIL mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of STIL mRNA25658374
D010126OzoneOzone results in decreased expression of STIL mRNA24336422
C500026palbociclibpalbociclib results in decreased expression of STIL mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STIL mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of STIL mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of STIL mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of STIL mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of STIL mRNA]20059764
D010936Plant ExtractsPlant Extracts results in increased expression of STIL mRNA23557933
D011794QuercetinQuercetin results in decreased expression of STIL mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of STIL mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of STIL mRNA19167446
C059514resveratrolresveratrol results in decreased expression of STIL mRNA15767336
C017947sodium arsenitesodium arsenite results in decreased expression of STIL mRNA17998272
D018038Sodium SeleniteSodium Selenite results in decreased expression of STIL mRNA24383545
D053260SootSoot results in increased expression of STIL mRNA22461453
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of STIL mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of STIL mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STIL mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STIL mRNA20106945|2163298
D013893ThiramThiram results in increased expression of STIL mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of STIL mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STIL mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of STIL mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of STIL mRNA19140230
D014520UrethaneUrethane results in increased expression of STIL mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of STIL gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22020124  24076405  25385835  26638075  
GO ID GO Term Qualifier Evidence PubMed
GO:0000578embryonic axis specification-ISS-  
GO:0001701in utero embryonic development-ISS-  
GO:0001843neural tube closure-ISS-  
GO:0001947heart looping-ISS-  
GO:0007052mitotic spindle organization-IBA21873635  
GO:0007052mitotic spindle organization-IMP22349705  
GO:0007224smoothened signaling pathway-IBA21873635  
GO:0007224smoothened signaling pathway-ISS-  
GO:0007368determination of left/right symmetry-ISS-  
GO:0008283cell proliferation-TAS8825637  
GO:0021915neural tube development-ISS-  
GO:0030900forebrain development-ISS-  
GO:0030903notochord development-ISS-  
GO:0033504floor plate development-ISS-  
GO:0035264multicellular organism growth-ISS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0046599regulation of centriole replication-IMP22020124  
GO:0051298centrosome duplication-IBA21873635  
GO:0051298centrosome duplication-IDA22349705  
GO:0051298centrosome duplication-IMP22349705  
GO:0071539protein localization to centrosome-IBA21873635  
GO:0071539protein localization to centrosome-IMP22349705  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA22349705  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA21399614  22349705  
GO:0005814centriole-IBA21873635  
GO:0005814centriole-IDA22020124  22349705  25385835  
GO:0005829cytosol-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26045845StIL-17 gene polymorphisms in the development of pulmonary tuberculosis. (2015)Du JInt J Clin Exp Pathol