Gene: BCL11B

64919
ATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IMD49|RIT1|ZNF856B|hRIT1-alpha
B cell CLL/lymphoma 11B
protein-coding
14q32.2
Ensembl:ENSG00000127152 MIM:606558 Vega:OTTHUMG00000028967 UniprotKB:Q9C0K0
NG_027894.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.959e-1 (AD)  7.200e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRD10.856
GABRA50.849
GRM40.839
EPHA70.827
GPR120.818
PTPN50.818
ANO30.815
SEZ60.815
SYNPR0.812
ADCY50.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.536
TFPI2-0.514
CSAG1-0.512
RUNX3-0.506
KIAA0040-0.484
WWTR1-0.478
RAB13-0.474
TRIP10-0.474
CNN2-0.472
FLT3LG-0.471

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BCL11B mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11B mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of BCL11B mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to BCL11B promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BCL11B mRNA21569818
C006780bisphenol Abisphenol A results in decreased methylation of BCL11B promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of BCL11B mRNA25181051
D002104CadmiumCadmium results in decreased expression of BCL11B mRNA23358151
D002737ChloropreneChloroprene results in decreased expression of BCL11B mRNA23125180
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of BCL11B mRNA23640034
D013759DronabinolDronabinol results in increased expression of BCL11B mRNA21955143
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BCL11B mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BCL11B mRNA21266533
D002117CalcitriolCalcitriol results in decreased expression of BCL11B mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BCL11B mRNA"22485181
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of BCL11B mRNA"27840820
D000431EthanolEthanol results in decreased expression of BCL11B mRNA21955143
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of BCL11B mRNA22085904
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of BCL11B mRNA23649840
C540355fenamidonefenamidone results in decreased expression of BCL11B mRNA27029645
D005473FluoxetineFluoxetine results in decreased expression of BCL11B mRNA17033635
D005839GentamicinsGentamicins results in increased expression of BCL11B mRNA22061828
C004312glycidolglycidol results in increased expression of BCL11B mRNA24915197
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of BCL11B mRNA22467014
D019290Megestrol Acetate[Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of BCL11B mRNA22085904
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of BCL11B mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of BCL11B mRNA22108045
D009020MorphineMorphine results in increased expression of BCL11B mRNA21955143
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BCL11B mRNA"25554681
D009538NicotineNicotine results in increased expression of BCL11B mRNA21955143
C006253pirinixic acidpirinixic acid results in decreased expression of BCL11B mRNA17426115|2081375
D011441PropylthiouracilPropylthiouracil results in decreased expression of BCL11B mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BCL11B mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of BCL11B mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of BCL11B gene28589171
D012999SomanSoman results in decreased expression of BCL11B mRNA19281266
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of BCL11B mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCL11B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCL11B mRNA19465110
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BCL11B mRNA28111298
C012589trichostatin Atrichostatin A results in increased expression of BCL11B mRNA24935251
C012589trichostatin Atrichostatin A results in decreased expression of BCL11B protein24204683
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL11B mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BCL11B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BCL11B mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of BCL11B gene29154799
D014635Valproic Acid[Valproic Acid co-treated with BDNF protein] results in decreased expression of BCL11B protein24204683
C025643vinclozolinvinclozolin affects the expression of BCL11B mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of BCL11B mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI17245431  23752268  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003334keratinocyte development-IEA-  
GO:0003382epithelial cell morphogenesis-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010837regulation of keratinocyte proliferation-IEA-  
GO:0019216regulation of lipid metabolic process-IEA-  
GO:0021773striatal medium spiny neuron differentiation-IEA-  
GO:0021902commitment of neuronal cell to specific neuron type in forebrain-IEA-  
GO:0031077post-embryonic camera-type eye development-IEA-  
GO:0033077T cell differentiation in thymus-IEA-  
GO:0033153T cell receptor V(D)J recombination-IEA-  
GO:0035701hematopoietic stem cell migration-IMP27959755  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043368positive T cell selection-IEA-  
GO:0045664regulation of neuron differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP16809611  
GO:0046632alpha-beta T cell differentiation-IEA-  
GO:0048538thymus development-IEA-  
GO:0071678olfactory bulb axon guidance-IEA-  
GO:0097535lymphoid lineage cell migration into thymus-IMP27959755  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res